中国科学技术大学免疫学研究所 发表论文

2008年

1. Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury. Hepatology. 2008-02
2. Poly I:C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway. BMC Cancer. 2008-01
3. Bcl-xL is associated with the anti-apoptotic effect of IL-15 on the survival of CD56(dim) natural killer cells. Mol Immunol 2008-02

2007年

1. Toll-like receptor 3 agonist induces impairment of uterine vascular remodeling and fetal losses in CBA x DBA/2 mice. J Reprod Immunol. 2007-06
2. NK3-like NK cells are involved in protective effect of polyinosinic- polycytidylic acid on type 1 diabetes in nonobese diabetic mice. J Immunol. 2007-02
3. Recognition of double-stranded RNA by TLR3 induces severe small intestinal injury in mice. J Immunol. 2007-04
4. Toll-like receptor 3 agonist enhances IFN-gamma and TNF-alpha production by murine uterine NK cells. Int Immunopharmacol. 2007-03
5. Liver-specific HBsAg transgenic mice are over-sensitive to Poly(I:C)-induced liver injury in NK cell- and IFN-gamma-dependent manner. J Hepatol. 2007-08
6. NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice. Proc Natl Acad Sci U S A. 2007-05
7. Activation of human natural killer cells by recombinant membrane-expressed fractalkine on the surface of tumor cells. Oncol Rep 2007-06
8. STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes. Oncol Rep. 2007-06
9. Impairment of liver regeneration correlates with activated hepatic NKT cells in HBV transgenic mice. Hepatology. 2007-06
10. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology. 2007-09
11. Application of optical tweezers in the research of molecular interaction between lymphocyte function associated antigen-1 and its monoclonal antibody. Cell Mol Immunol. 2007-01
12. Preferential distribution of NK cells into uteri of C57Bl/6J mice after adoptive transfer of lymphocytes. J Reprod Immunol/Epub 2007-07
13. Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells. Oncol Rep. 2007-09
14. Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice. BMC Cancer. 2007-08
15. The roles of innate immune cells in liver injury and regeneration. Cell Mol Immunol. 2007-08
16. Down-regulation of surface fractalkine by RNA interference in B16 melanoma reduced tumor growth in mice. Biochem Biophys Res Commun./Epub 2007-10
17. High Expression of NKG2A/CD94 and Low Expression of Granzyme B Are Associated with Reduced Cord Blood NK Cell Activity. Cell Mol Immunol. 2007-10

2006年

1. Codon optimization, expression and characterization of an internalizing anti-ErbB2 single chain antibody in Pichia pastoris. Protein Expression and Purification 2006-05
2. A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 gene enhanced potency of HBV DNA vaccine. Vaccine 2006-04
3. Involvement of interaction between Fractalkine and CX3CR1 in cytotoxicity of natural killer cells against tumor cells. Oncol Rep. 2006-02
4. Human interleukin-15 improves engraftment of human T cells in NOD-SCID mice. Clin Vaccine Immunol. 2006-02
5. Pre-activation of T lymphocytes by low dose of concanavalin A aggravates toll-like receptor-3 ligand-induced NK cell-mediated liver injury. Int Immunopharmacol. 2006-05
6. The differential effects of low dose and high dose concanavalin A on cytokine profile and their importance in liver injury. Inflamm Res. 2006-04
7. Selective elimination of hepatic natural killer T cells with concanavalin A improves liver regeneration in mice. Liver Int. 2006-04
8. Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism. J Hepatol. 2006-03
9. Human NK cells positively regulate gammadelta T cells in response to Mycobacterium tuberculosis. J Immunol. 2006-02
10. Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. Hepatology. 2006-06
11. mRNA secondary structure at start AUG codon is a key limiting factor for human protein expression in Escherichia coli. Biochem Biophys Res Commun. 2006-10

2005年

1. Purification and characterization of a single-chain chimeric anti-p185 antibody expressed by CHO-GS system. Protein Expression & Purification 2005-05
2. Identification of novel nuclear lacalization signal within the ErbB-2 protein. Cell Research 2005-07
3. Expression of a recombinant anticoagulant C-type lectin-like protein ACFI in Pichia pastoris: heterodimerization of two subunits is required for its f Toxicon 2005-12
4. A C-type lectin-like protein from Agkistrodon acutus venom binds to both platelet glycoprotein Ib and coagulation factor IX/factor X. Biochemical and Biophysical Research Communications 2005-07
5. A novel HBV DNA vaccine based on T cell epitopes and its potential therapeutic effect in HBV transgenic mice. International Immunology, 2005-01
6. The inhibitory effects of synthetic short peptides, mimicking MICA and targeting at NKG2D receptors, on function of NK cells. Peptides 2005-03
7. Antitumor effects of recombinant human prolactin in human adenocarcinoma-bearing SCID mice with human NK cell xenograft. Int Immunopharmacol. 2005-02
8. Activation and function of hepatic NK cells in hepatitis B infection: an underinvestigated innate immune response. J Viral Hepat. 2005-01
9. Differential roles of constitutively activated ERK1/2 and NF-kappa B in cytotoxicity and proliferation by human NK cell lines. Int Immunopharmacol 2005-05
10. Protective effects of a Traditional Chinese Medicine, You-Gui-Wan, on steroid-induced inhibition of cytokine production in mice. Int Immunopharmacol. 2005-06
11. Opposing effect of IFNgamma and IFNalpha on expression of NKG2 receptors: negative regulation of IFNgamma on NK cells. Int Immunopharmacol. 2005-06
12. Imbalance of NKG2D and its inhibitory counterparts: How does tumor escape from innate immunity? Int Immunopharmacol. 2005-07
13. Regulation of NK cell activation by stimulatory and inhibitory receptors in tumor escape from innate immunity. Front Biosci 2005-09
14. In vivo and in vitro encystment of Echinochasmus liliputanus cercariae and biological activity of the metacercariae. Journal of parasitology 2005-06
15. Field evaluation of a rapid, visually read colloidal dye immunofiltration assay (CDIFA) for the screening of schistosomiasis japonica in low transmiss Bulletin of the World Health Organization. 2005-01
16. Impaired function of hepatic natural killer cells from murine chronic HBsAg carriers. Int Immunopharmacol. 2005-12
17. Impaired NK cell cytotoxicity by high level of interferon-γ in concanavalin A-induced hepatitis. Can J Physiol Pharmacol. 2005-11
18. Tumor-induced suppression of interferon-gamma production and enhancement of interleukin-10 production by natural killer (NK) cells: paralleled to CD4+ Mol Immunol. 2005-05
19. Involvement of human natural killer cells in asthma pathogenesis: natural killer 2 cells in type 2 cytokine predominance. J Allergy Clin Immunol. 2005-04
20. Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. PNAS. 2005-11

2004年

1. IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4+ T cell- and STAT3-dependent manners. J Immunol. 2004-04
2. Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease. Hepatology. 2004-01
3. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem Biophys Res Commun. 2004-02
4. A balanced expression of two chains of heterodimer protein, the human interleukin-12, improves high-level expression of the protein in CHO cells. Biochem Biophys Res Commun. 2004-01
5. Expression of prolactin receptor and response to prolactin stimulation of human NK cell lines. Cell Res. 2004-02
6. Characterization of stem cell factor gene-modified human natural killer cell line, NK-92 cells: implication in NK cell-based adoptive cellular immunot Oncol Rep. 2004-05
7. Detection of intracellular phosphorylated ERK1/2 in natural killer cells by flow cytometry. Haematologica. 2004-01
8. Characterization of interleukin-15 gene-modified human natural killer cells: implications for adoptive cellular immunotherapy. Haematologica. 2003-11
9. Involvement of natural killer cells in PolyI:C-induced liver injury. J Hepatol. 2004-12

2003年

1. In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats Gastroenterology 2003-07
2. Expression,refolding and preliminary characterization of recombinant snake venom metalloproteinases: Implication for the hemorrhagic mechanism. Chinese Science Bulletin, 2003-10
3. Characterization and utilization of two novel anti-erbB-2 monoclonal antibodies in detection of soluble ErbB-2 for breast cancer prognosis. Cancer letter 2003-04
4. Construction, expression and characterization of the engineered antibody against tumor surface antigen, p185c-erbB-2. Cell Research 2003-01
5. Recombinant human prolactin improves antitumor effects of murine natural killer cells in vitro and in vivo. Neuroimmunomodulation. 2003-10
6. Development of a rapid, sensitive, dye immunoassay for schistosomiasis diagnosis: a colloidal dye immunofiltration assay. J Immunol Methods. 2003-09
7. Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients. Oncol Rep. 2003-09
8. IFNalpha regulates NK cell cytotoxicity through STAT1 pathway Cytokine 2003-09
9. Immunologic and hematopoietic effects of recombinant human prolactin after syngeneic bone marrow transplantation in mice. Biol Blood Marrow Transplant. 2003-07
10. Use of interleukin-15 for preparation of adherent NK cells from human peripheral blood: comparison with interleukin-2. J Immunol Methods. 2003-08
11. The effects of natural killer-cell depletion on ex vivo expansion of hematopoietic progenitor cells from umbilical cord blood. Haematologica. 2003-05

2002年

1. Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver Oncogene 2002-01
2. Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells: differential involvemen J Biol Chem 2002-06
3. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS J Clin Invest 2002-11
4. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun. 2002-11

2000年

1. IL-1 beta attenuates IFN-alpha beta-induced antiviral activity and STAT1 activation in the liver: involvement of proteasome-dependent pathway. J Immunol. 2000-10