主要研究成果－代表性论著
Yang MS, Wang XF, Qin W, Feng GY, He L. Evidence for a major susceptibility locus at 11q22.1-23.3 has been detected in a large Chinese family with pure grand mal epilepsy. Neurosci Lett. 2003 Aug 7;346(3):133-6.

Xing QH, Wu SN, Lin ZG, Li HF, Yang JD, Feng GY, Wang MT, Yang WW, He L. Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene in schizophrenia. Schizophr Res. 2003 Dec 1;65(1):9-14.

Gao N, Zhang Z, Jiang BH, Shi X. Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem Biophys Res Commun. 2003 Oct 31;310(4):1124-32.

Xing QH, Wang MT, Chen XD, Feng GY, Ji HY, Yang JD, Gao JJ, Qin W, Qian XQ, Wu SN, He L. A gene locus responsible for dyschromatosis symmetrica hereditaria (DSH) maps to chromosome 6q24.2-q25.2. Am J Hum Genet. 2003 Aug;73(2):377-82. Epub 2003 Jun 12.

Bian L, Yang JD, Guo TW, Sun Y, Duan SW, Chen WY, Pan YX, Feng GY, He L. Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese. Neurology. 2004 Jul 27;63(2):241-5.

Yu L, Yang MS, Zhao J, Shi YY, Zhao XZ, Yang JD, Liu ZJ, Gu NF, Feng GY, He L. An association between polymorphisms of the interleukin-10 gene promoter and schizophrenia in the Chinese population. Schizophr Res. 2004 Nov 1;71(1):179-83.

Qian X, Shu A, Qin W, Xing Q, Gao J, Yang J, Feng G, He L. A novel insertion mutation in the FOXL2 gene is detected in a big Chinese family with blepharophimosis-ptosis-epicanthus inversus. Mutat Res. 2004 Oct 4;554(1-2):19-22.

Guo TW, Zhang FC, Yang MS, Gao XC, Bian L, Duan SW, Zheng ZJ, Gao JJ, Wang H, Li RL, Feng GY, St Clair D, He L. Positive association of the DIO2 (deiodinase type 2) gene with mental retardation in the iodine-deficient areas of China. J Med Genet. 2004 Aug;41(8):585-90.

Guo S, Shi Y, Zhao X, Duan S, Zhou J, Meng J, Yang Y, Gu N, Feng G, Liu H, Zhu S, He L. No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population. Neurosci Lett. 2004 Oct 14;369(2):168-72.

Gao J, Zhang F, Guo T, Gao X, Duan S, Wang H, Zheng Z, Huang T, Feng G, St Clair D, He L. Distribution of apolipoprotein E allele frequencies of the Han Chinese in an iodine-deficient mountainous area. Ann Hum Biol. 2004 Sep-Oct;31(5):578-85.

Gao B, He L. Answering a century old riddle: brachydactyly type A1. Cell Res. 2004 Jun;14(3):179-87.

Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L. Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus eta-analysis. Biol Psychiatry. 2005 Jan 15;57(2):139-44.

Zou F, Li C, Duan S, Zheng Y, Gu N, Feng G, Xing Y, Shi J, He L. A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population. Schizophr Res. 2005 Mar 1;73(2-3):257-61.

Zheng Y, Li H, Qin W, Chen W, Duan Y, Xiao Y, Li C, Zhang J, Li X, Feng G, He L. Association of the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase gene with schizophrenia in the Chinese Han population. Biochem Biophys Res Commun. 2005 Mar 25;328(4):809-15.

Chen QY, Chen Q, Feng GY, Lindpaintner K, Chen Y, Sun X, Chen Z, Gao Z, Tang J, He L. Case-control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population. Schizophr Res. 2005 Mar 1;73(2-3):269-74.

Bian L, Yang JD, Guo TW, Duan Y, Qin W, Sun Y, Feng GY, He L. Association study of the A2M and LRP1 Genes with Alzheimer disease in the Han Chinese. Biol Psychiatry. 2005 Nov 1;58(9):731-7. Epub 2005 Jul 25.

Zhou Y, Sun X, Jin L, Stringfield T, Lin L, Chen Y. Expression profiles of adiponectin receptors in mouse embryos. Gene Expr Patterns. 2005 Jun;5(5):711-5. Epub 2005 Mar 29.

Jin L, Zhou Y, Kuang C, Lin L, Chen Y. Expression pattern of TG-interacting factor 2 during mouse development. Gene Expr Patterns. 2005 Apr;5(4):457-62.

Zhang Y, Lu Y, Yuan BZ, Castranova V, Shi X, Stauffer JL, Demers LM, Chen F. The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. Oncogene. 2005 Jul 21;24(31):4873-82.

Ke ZJ, Calingasan NY, Karuppagounder SS, DeGiorgio LA, Volpe BT, Gibson GE. CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. J Neuroimmunol. 2005 Jul;164(1-2):85-92.

Le Y, Yu X, Ruan L, Wang O, Qi D, Zhu J, Lu X, Kong Y, Cai K, Pang S, Shi X, Wang JM. The immunopharmacological properties of transforming growth factor beta. Int Immunopharmacol. 2005 Dec;5(13-14):1771-82. Epub 2005 Aug 2.

Liu LZ, Fang J, Zhou Q, Hu X, Shi X, Jiang BH. Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer. Mol Pharmacol. 2005 Sep;68(3):635-43. Epub 2005 Jun 9.

Ke Z, Lin H, Fan Z, Cai TQ, Kaplan RA, Ma C, Bower KA, Shi X, Luo J. MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2. Int J Cancer. 2006 Jul 1;119(1):8-16.

Luo C, Wang X, Long J, Liu J. An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates. J Biochem Biophys Methods. 2006 Aug 31;68(2):101-11. Epub 2006 Apr 26.

Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W, Liu Y. RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells. J Biol Chem. 2006 Nov 3;281(44):33386-94. Epub 2006 Sep 6.

Gao N, Zhang Z, Jiang BH, Shi X. Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem Biophys Res Commun. 2003 Oct 31;310(4):1124-32.

Liu LZ, Fang J, Zhou Q, Hu X, Shi X, Jiang BH. Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer. Mol Pharmacol. 2005 Sep;68(3):635-43. Epub 2005 Jun 9.

Zhou Q, Meng D, Yan B, Jiang BH, Fang J. Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide. FEBS Lett. 2006 Oct 2;580(22):5161-6. Epub 2006 Sep 5.

Sun X, Han R, Wang Z, Chen Y. Regulation of adiponectin receptors in hepatocytes by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Diabetologia. 2006 Jun;49(6):1303-10. Epub 2006 Apr 12.

Zhou Y, Sun X, Jin L, Stringfield T, Lin L, Chen Y. Expression profiles of adiponectin receptors in mouse embryos. Gene Expr Patterns. 2005 Jun;5(5):711-5. Epub 2005 Mar 29.

Jin L, Zhou Y, Kuang C, Lin L, Chen Y. Expression pattern of TG-interacting factor 2 during mouse development. Gene Expr Patterns. 2005 Apr;5(4):457-62.

Wang X, Wang B, Fan Z, Shi X, Ke ZJ, Luo J. Thiamine deficiency induces endoplasmic reticulum stress in neurons. Neuroscience. 2007 Feb 9;144(3):1045-56. Epub 2006 Nov 28.

Ke Z, Lin H, Fan Z, Cai TQ, Kaplan RA, Ma C, Bower KA, Shi X, Luo J. MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2. Int J Cancer. 2006 Jul 1;119(1):8-16.

Pang SS, Le YY. Role of resistin in inflammation and inflammation-related diseases. Cell Mol Immunol. 2006 Feb;3(1):29-34.

Huang C, Zhang Y, Gong Z, Sheng X, Li Z, Zhang W, Qin Y. Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. Biochem Biophys Res Commun. 2006 Sep 22;348(2):571-8. Epub 2006 Jul 28.

Wu D, Zhai Q, Shi X. Alcohol-induced oxidative stress and cell responses. J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S26-9.