王健,男,1975年出生,博士,教授。1998 年本科毕业于北京大学生命科学院细胞生物学与遗传学专业;1999 年开始于美国 Wayne State University 师从 DL Gatti 教授从事蛋白质结构与功能的研究,2003 年获分子生物学与生物化学博士学位;2003 年起在美国 Emory University 医学院作蛋白质生物信息学和蛋白组学的博士后工作。2004 年开始在上海大学生命科学院从事生物信息学的研究工作。
发表论文 1. Liao L, Cheng D, Wang J, Duong DM, Losik TG, Gearing M, Rees HD, Lah JJ, Levey AI, Peng J (2004). Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection. J Biol Chem. 279(35):37061-8.
2. Xu X, Wang J, Grison C, Petek S, Coutrot P, Birck MR, Woodard RW, Gatti DL(2003). Structure-Based Design of Novel Inhibitors of KDO8PS. Drug Des Discov. 18(2-3):91-9
3. Wang J, Duewel HS, Stuckey JA, Woodard RW, Gatti DL(2002). Function of His185 in Aquifex aeolicus KDO8PS. J Mol Biol. 324(2):205-14
4. Wang J, Ortiz-Maldonado M, Entsch B, Massey V, Ballou D, Gatti DL(2002). Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase. Proc Natl Acad Sci USA. 99(2):608-13
5. Wang J, Duewel HS, Woodard RW, Gatti DL(2001). Structures of Aquifex aeolicus KDO8PS in complex with R5P and PEP, and with a bisubstrate inhibitor: role of active site water in catalysis. Biochemistry. 40(51):15676-83
6. Duewel HS, Radaev S, Wang J, Woodard RW, Gatti DL(2001). Substrate and metal complexes of KDO8PS from Aquifex aeolicus at 1.9-A resolution. Implications for the condensation mechanism. J Biol Chem. 276(11):8393-402.
王健教授
九月 10th, 2007 | posted by mybiolab