高福研究员 病原微生物与分子免疫研究中心 主任
高福 英文名 : George Fu Gao 博士（ DPhil-Oxon ）
所长，研究员，博士生导师，科学院“百人计划”入选者
主要研究领域
本实验室主要研究蛋白质 - 蛋白质之间的相互作用，尤其是有关分子免疫学与分子病毒学方面的蛋白质相互作用。
继人类基因组计划（ HGP ）完成之后，科学家们把注意力逐渐转移到蛋白质组学的研究上。解析蛋白质之间的相互作用对于阐明细胞乃至整个生命活动的分子机制具有举足轻重的意义。在蛋白质相互作用过程中，蛋白质的不同构像变化起着十分重要的作用，这种不同构像的转换赋予了相同（指一级序列相同）的蛋白质以多种功能，这也就部分地解释了人类基因组完成后发现的基因数目（ Open reading frame ）远远的少于人们此前的预测。本实验室主要借助于多种蛋白质化学技术，生物物理技术（如 BIAcore SPR 分析，园二色等）， X 射线衍射和 NMR 技术，酵母双杂交技术，体外大量制备蛋白质的技术以及各种细胞生物学技术等，开展相关研究。
在分子水平上， T 细胞的免疫识别包括了多种蛋白质与蛋白质之间的相互作用，其中包括 T 细胞与抗原递呈细胞之间表面受体与其配体之间的作用，以及其后参与细胞胞浆内信号传导的蛋白质之间的相互作用。近些年来发现， Toll-like 受体识别的是多糖，多糖与受体蛋白质之间的相互作用在机体天然免疫过程中也越来越显得重要。搞清楚这种相互作用，人们可以有意识地去干预免疫系统，从而增强（在免疫力低下的情况下）或降低（在免疫力病理性的过强时，如自身免疫病）免疫力，达到防病治病的目的。
病毒感染始于病毒侵入被感染的细胞中，在这一过程中，同样有多种蛋白质 - 蛋白质之间的相互作用，尤其是带囊膜的病毒，囊膜蛋白与细胞表面的受体（蛋白质或其它物质）的相互作用改变了细胞脂质双层膜的稳定态，导致了病毒遗传物质的进入。在病毒致病过程中，病毒编码的蛋白质与宿主细胞内蛋白质之间的相互作用起着重要的作用，寻找病毒蛋白质相互作用的宿主蛋白将有助于阐明不同病毒引发的疾病的分子致病机制。研究这些蛋白质 - 蛋白质相互作用，有利于进一步研发阻断这一过程的活性物质，从而达到防病治病的目的。
主要履历及经历
1979-1983 年 山西农业大学 学士
1983-1986 年 北京农业大学 硕士
1986-1991 年 北京农业大学 助教 / 讲师
1991-1994 年 英国牛津大学 博士 （ DPhil-Oxon ）（师从 David H L Bishop, Ernest A Gould ）
1994 年(3个月) 加拿大 Calgary University 博士后（师从 Robert Bell
1995-1998 年 英国牛津大学 博士后（师从 John I bell, Andrew J McMichael, Bent K Jakobsen ）
1999-2001 年 美国哈佛大学 / 哈佛医学院 博士后（师从 Don C Wiley, Stephen C Harrison ）（工作期间资助：英国 Wellcome Trust International Travelling Fellow ）
2001-2004 年英国牛津大学 讲师、博士生导师、 Group leader
2004 年 - 现在中国科学院微生物研究所 所长、研究员、博士生导师
获奖情况
中国科学技术协会首届“青年科技奖”获得者（ 1988 年）
北京市科学技术协会“青年优秀论文奖”获得者（ 1988 年）
中国微生物学会“青年优秀论文奖” 获得者（ 1989 年）
英国文化委员会与中国国家教育委员会“中英友好奖学金” 获得者（ 1991 年）
英国 Wellcome Trust “International Travelling Fellow” (1998 年 )
国家自然科学基金委员会“海外青年学者合作研究基金”(杰出青年B类)获得者(2002年)
教育部“春晖计划”学术休假基金获得者（ 2003 年）
中国科学院“百人计划”获得者（ 2004 年）
973首席科学家（ 2005年 ）
国家自然科学基金委员会“杰出青年科学基金”（A类）（ 2005年 ）
学术兼职
1.中国农业大学兼职教授
2.武汉大学客座教授
3. 中华预防医学会理事
4.中国生物工程学会常务副理事长
5.首都医科大学传染病系学术委员会副主任
6.亚洲生物资源中心联盟 副主席
7.中国人民解放军军事医学科学院“病原微生物生物安全国家重点实验室”学术委员会委员
8.中国科学技术协会第七届全国委员会委员
9.中国科学院微生物研究所第七届学术委员会主任
10.JGV（Journal of General Virology）杂志编委
11.Zoonoses and Public Health杂志编委
12.《中国病毒学》责任编委
13.《药物生物技术》杂志编委
14.《微生物与感染》杂志编委
主要论文
1. David K Cole*, Pierre J Rizhallah, Jonathan M Boulter, Malkit Sami, Anne-lise Vuidepot, Meir Glick, Feng Gao, John I Bell, Bent K Jakobsen*, George F Gao*, Computational design and crystal structure of an enhanced affinity mutant human CD8 co-receptor, PROTEINS: Structure, Function, and Bioinformatics (in press) (with front cover illustration)
2. Fuliang Chu, Zhiyong Lou, Yu Wai Chen, Yiwei Liu, LiLi Zong, Bin Gao Abdul Hamid Khan, John I. Bell, Zihe Rao and George F. Gao*,2007, First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escape, The Journal of Immunology, 178(2):944-952
3. Suhua Chang, Jiajie Zhang, Xiaoyun Liao, Xinxing Zhu, Dahai Wang, Jiang Zhu, Tao Feng, Baoli Zhu, George F. Gao, Jian Wang, Huanming Yang, Jun Yu * and Jing Wang *, 2006, Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research, Nucleic Acids Research, 35(Database issue):D376-80
4. Zhiyong Lou, Yanhui Xu, Kehui Xiang, Nan Su, Lan Qin, Xu Li, George F. Gao, Mark Bartlam and Zihe Rao, 2006, Crystal structures of Nipah and Hendra virus fusion core proteins, FEBS Journal, 273 : 4538–4547
5. Yueyong Liu, Yanhui Xu, Zhiyong Lou, Jieqing Zhu, Xuebo Hu, George F. Gao , Bingsheng Qiu *, Zihe Rao *, Po Tien *, 2006, Structural characterization of Mumps virus fusion protein core, Biochemical and Biophysical Research Communications 348: 916–922
6. Yuxia Zhang, Yanlu Zan, Ming Shan, Changmei Liu, Ming Shi, Wei Li, Zhixin Zhang, Na Liu, Fusheng Wang, Weidong Zhong, Fulian Liao, George F. Gao *, Po Tien *, 2006, Effects of heat shock protein gp96 on human dendritic cell maturation and CTL expansion, Biochemical and Biophysical Research Communications 344: 581–587
7. Zheng Fan , Yue Zhuo, Xinyu Tan, Zhi Zhou, Jiangang Yuan, Boqin Qiang, Jinghua Yan, Xiaozhong Peng, George F. Gao*, 2006, SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system, Journal Medical Virology (in press)
8. David K Cole*, Pierre J Rizhallah, Jonathan M Boulter, Malkit Sami, Anne-lise Vuidepot, Meir Glick, Feng Gao, John I Bell, Bent K Jakobsen*, George F Gao*, 2006, Computational design and crystal structure of an enhanced affinity mutant human CD8aa co-receptor, PROTEINS: Structure, Function, and Bioinformatics (in press).
9. Shibichakravarthy Kannan, Aaron Audet, Jessica Knittel, Saman Mullegama, George F.Gao and Min Wu, 2006, Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells. European journal of Immunology, 36:1739-1752
10. Minghai Zhou, Dongping Xu, Xiaojuan Li, Hongtao Li, Ming Shan, Jiaren Tang, Min Wang, Fu-Sheng Wang, Xiaodong Zhu, Hua Tao, Wei He, Po Tien*, and George F Gao*，2006, Screening and Identification of Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific CTL Epitopes, Journal of Immunology, 177: 2138-2145
11. Jiaqi Tang*#, Changjun Wang#, Youjun Feng#, Weizhong Yang#, Huaidong Song#, Zhihai Chen#, Hongjie Yu#, Xiuzhen Pan, Xiaojun Zhou, Huaru Wang, Bo Wu, Haili Wang, Huamei Zhao, Ying Lin, Jianhua Yue, Zhenqiang Wu, Xiaowei He, Feng Gao, Abdul Hamid Khan, Jian Wang, Guo-Ping Zhao, Yu Wang*, Xiaoning Wang*, Zhu Chen, George F Gao*， 2006，Streptococcal toxic shock syndrome caused by Streptococcus suis serotype2. PLoS Medicine，3(5):668-676 (＃shared the first author)
12. David K. Cole, Pierre J. Rizkallah, Feng Gao, Neil I. Watson, Jonathan M. Boulter, John I. Bell, Malkit Sami, George F. Gao* & Bent K. Jakobsen*.2006.Crystal structure of HLA-A*2402 complexed with a telomerase peptide. European Journal of Immunology. 36:170-179
13. Li X, Liu X, Sun F, Gao J, Zhou H, Gao GF, Bartlam M, Rao Z. Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor. Biochemical and Biophysical Research Communications. 2006 Jan 6; 339(1):407-14
14. Jinhua Liu＃, Haixia Xiao＃, Fumin Lei＃, Qingyu Zhu, Kun Qin, Xiaowei Zhang, Xinglin Zhang, Deming Zhao, Guihua Wang, Youjun Feng, Juncai Ma, Wenjun Liu, Jian Wang, George F. Gao*. 2005. Highly pathogenic H5N1 influenza virus infection in migratory birds. Science. 309:1206(＃shared the first author)
15. Ling Ni, Linqing Zhao, Yuan Qian, Jieqing Zhu, Zhibo Jin, Yu Wai Chen, Po Tien*, George F Gao*, 2005, Design and characterization of human respiratory syncytial virus entry inhibitors. Antiviral Therapy. 10:833-840
16. Jieqing Zhu, Xiuli Jiang, Yueyong Liu, Po Tien, George F Gao.2005. Design and characterization of viral polypeptide inhibitors targeting Newcastle disease virus fusion. Journal of Molecular Biology. 354:601-613
17. Ling Ni, Linqing Zhao , George F. Gao , Yuan Qian ,*, Po Tien ,* 2005.The antibodies directed against N-terminal heptad-repeat peptide of hRSV fusion protein and its analog-5-Helix inhibit virus infection in vitro. Biochemical and Biophysical Research Communications 331:1358-1364
18. Ling Ni, George F. Gao,*, Po Tien ,* Rational design of highly potent HIV-1 fusion inhibitory proteins: Implication for developing antiviral therapeutics. Biochemical and Biophysical Research Communications 332:831-836
19. Zheng Zhang, Dongping Xu, Yonggang Li, Lei Jin, Ming Shi, Min Wang, Xianzhi Zhou, Hao Wu, George F. Gao, Fu-Sheng Wanga,* 2005. Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome. Clinical Immunology 116(3):225-35.
20. Fuliang Chu ,Zhiyong Lou, Bin Gao, John I. Bell, Zihe Rao and George F. Gao*，2005， Complex assembly, crystallization and preliminary X-ray crystallographic studies of rhesus macaque MHC Mamu-A*01 complexed with an immunodominant SIV-Gag nonapeptide. Acta Crystallographica Section F Structural Biology and Crystallization Communications F61: 614–616.
21. Li,H., Zhou,M., Han,J., Zhu,X., Dong,T., George F. Gao*, and Po Tien* , 2005, Generation of murine CTL by a hepatitis B virus-specific peptide and evaluation of the adjuvant effect of heat shock protein glycoprotein 96 and its terminal fragments. The Journal of Immunology Jan 1;174(1):195-204
22. George F. Gao. 2005, Filling the hole: evidence of a small molecule binding to the fusion core pocket in human respiratory syncytial virus. Expert Opinion on Investigational Drugs 14(2): 195-197
23. Yuan, F., Lou, Z., Li, X., Chen, Y., John I. Bell, Zihe Rao, George F. Gao*. 2005，Refolding，crystallization and preliminary X-ray structural studies of the West Nile virus envelope(E) protein domain Ⅲ. Acta Crystallographica Section F Structural Biology and Crystallization Communications F61，421-423
24. Li, S., Zhu, J., Peng, Y., Cui, S., Wang, C., George F. Gao*., Tien, P*. 2005, Characterization of BIV Env core: Implication for mechanism of BIV-mediated cell fusion. Biochemical and Biophysical Research Communications (BBRC) 329(2005) 603-609
25. David K. Cole, Pierre J. Rizkallah, Malkit Sami, Nikolai M. Lissin, Gao.F., John I. Bell, Jonathan M. BBoulter, Meir Glick, Anne-Lise Vuidepot, Bent K. Jakobsen and George F. Gao*. Crystallization and preliminary X-ray structural studies of a high-affinity CD8ααco-receptor to pMHC. Acta Crystallographica Section F Structural Biology and Crystallization Communications F61
26. Ni, L., Zhu, J., Zhang, J., Yan, M., George F. Gao*, Po Tien*. 2005, Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain. Biochemical and Biophysical Research Communications (BBRC) 330：39-45.
27. Wang, X., Bai, Y., Zhang, G., Zhao, J., Wang, M., George F. Gao*. 2005, Structure and function study of paramyxovirus fusion protein heptad repeat peptides. Archives of Biochemistry and Biophysics(ABB) 436(2005) 316-322
28. Xu,D.,Zhang,Z.,Jin,L.,Chu,F.,Mao,Y.,Wang,H.,Liu,M.,Wang,M.,Zhang,L., G.F. Gao and Wang,F.S.2005,Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase. European Journal of Clinical Microbiology & Infectious Diseases 24:165-171
29. Xu, Y., Lou, Z., Liu, Y., Pang, H., Tien, P., Gao, G.F. , & Rao*, Z., 2004 ， Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core. Journal of Biological Chemistry (JBC) 279(47):49414-9
30. Xu, Y., Liu, Y., Lou, Z., Qin, L., Li, X., Bai, Z., Tien, P., Gao*, G.F. & Rao*, Z., 2004, Structural basis for coronavirus-mediated virus membrane fusion: crystal structure of MHV spike protein fusion core, Journal of Biological Chemistry (JBC) 279 (29):30514-22.
31. Cole, D.K. & Gao*, G.F. , 2004, CD8: Adhesion molecule, co-receptor and immuno-modulator (invited review), Cellular and Molecular Immunology 1 (2): 81-88.
32. Pang, H., Bartlam, M., Zeng, Q., Miyatake, H., Hisano, T., Miki, K., Wong, L-L, Gao, G.F. & Rao, Z., 2004, Crystal structure of human pirin: an iron binding nuclear protein and transcription cofactor. Journal of Biological Chemistry (JBC) 279 (2): 1491-1498.
33. Xu, D., Zhang, Z., Chu , F., Li, Y., Jin, L., Zhang, L., Gao, G.F. & Wang, F.-S., 2004, Genetic variation of SARS coronavirus in Beijing hospital, Emerging Infectious Diseases 10 (5): 789-794.
34. Gao, G.F. , 2004, Just folding back: Convergence of viral fusion mechanisms (Monitor), Drug Discovery Today 9: 288.
35. Xu, Y., Zhu, J., Liu, Y., Lou, Z., Yuan, F., Liu, Y., Cole, D.K., Ni, L., Su, N., Qin, L., Li, X., Bai, Z., Bell, J.I., Pang, H., Tien, P., Gao*, G.F. & Rao*, Z., 2004, Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus, Biochemistry 43(44):14064-71.
36. Zhu, X., Li, C., Lang, Z., Gao*, G.F. & Tien*, P., 2004, Significant correlation between expression level of HSP gp96 and the progression of hepatitis B virus induced diseases, World Journal of Gastroenterology 10 (8): 1141-1145.
37. Xu, Y., Cole, D.K., Lou, Z., Liu, Y., Qin, L., Li, X., Bai, Z., Yuan, F., Rao*, Z. & Gao*, G.F. , 2004，Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein. Protein Expression and Purification 38(1):116-22.
38. Xu, Y., Gao, S., Cole, D.K., Zhu, J., Su, N., Wang, H., Gao*, G.F. & Rao*, Z., 2004, Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses, Biochemical and Biophysical Research Communications (BBRC) 315 (3): 664-670
39. Zhu, J., Xiao, G., Xu, Y., Yuan, F., Zheng, C., Liu, Y., Cole, D.K., Yan, H., Bell, J.I., Rao, Z., Tien*, P. & Gao*, G.F. , 2004, Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein and identification of potent peptide inhibitors, Biochemical and Biophysical Research Communications (BBRC) 319: 283-288.
40. Liu, Y., Zhu, J., Feng, M., Tien, P. & Gao*, G.F. , 2004, Six-helix bundle assembly and analysis of the central core of mumps virus fusion protein. Archives of Biochemistry and Biophysics (ABB) 421: 143-148.
41. Yan, H., Xiao, G., Zhang, J., Hu, Y., Yuan, F., Cole, D.K., Zheng*, C. & Gao*, G.F. , 2004, SARS coronavirus induces apoptosis in Vero E6 cells, Journal of Medical Virology 73: 323-331.
42. Xu, Y., Lou, Z., Liu, Y., Cole, D.K., Su, N., Qin, L., Li, X., Bai, Z., Rao, Z. & Gao*, G.F. , 2004, Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus. Acta Crystallographica Section D Biological Crystallography D60: 1161-1164 .
43. Zhou, M., Xu, Y., Lou, Z., Cole, D.K., Li, X., Liu Y.,Tien, P., Rao*, Z. & Gao*, G.F. , 2004, complex assembly, crystallization and preliminary X-ray crystallographic studies of MHC H-2 k d complexed with an HBV core nonapeptide, Acta Crystallographica Section D Biological Crystallography 60(Pt 8):1473-5.
44. Wang, X., Xu, Y., Cole, D.K., Lou, Z., Liu, Y., Rao, Z., Wang*, M. & Gao*, G.F. , 2004, Biochemical, biophysical and preliminary X-ray crystallographic analyses of the fusion core of Sendai virus F protein, Acta Crystallographica Section D Biological Crystallography 60(Pt 9):1632-5.
45. Xu, Y., Bai, Z., Qin, L., Li, X., Gao*, G.F. & Rao*, Z., 2004, Crystallization and preliminary crystallographic analysis of the fusion core of the spike protein of the murine coronavirus mouse hepatitis virus (MHV). Acta Crystallographica Section D Biological Crystallography 60 (Pt 11):2013-5.
46. Xu, Y., Su, N., Qin, L.,Bai, Z., Gao, G.F. , & Rao*, Z., 2004, Crystallization and preliminary crystallographic analysis of the heptad-repeat complex of SARS coronavirus spike protein. Acta Crystallographica Section D Biological Crystallography D60 (Pt 12 Pt 2):2377-9.
47. 王晓佳，张卫红，汪明，高福，2004，囊膜病毒膜融合的分子机制。生物化学与生物物理进展 31（6）：482-491 。
48. Yang, H., Yang, M., Ding, Y., Liu, Y., Lou, Z., Zhou, Z., Sun, L., Mo, L.,Ye, S., Pang, H., Gao, G.F. , Anand, K., Bartlam, M., Hilgenfeld, R. & Rao, Z., 2003, The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proceedings of National Academy of Sciences USA (PNAS) 100 (23): 13190-13195.
49. Ding, Y., Xu, G., Yang, M., Yao , M., Gao, G.F. , Wang, L., Zhang, W. & Rao, Z., 2003, Crystal structure of the ectodomain of human FcRI. Journal of Biological Chemistry (JBC) 278 (30): 27966-27970. (with front cover illustration).
50. Wang, E., Sun, X., Qian Y., Zhao, L., Tien, P. & Gao* , G.F. , 2003, Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion. Biochemical and Biophysical Research Communications (BBRC) 302: 469-475.
51. Zhu, J., Ding, Y., Gao, F., Wu, T., Zhang, C.W.-H., Tien, P., Rao, Z. & Gao* , G.F. , 2003, Crystallization and preliminary X-ray crystallographic analysis of the trimer core from measles virus fusion protein. Acta Crystallographica Section D Biological Crystallography D59: 587-590.
52. Li, P., Zhu, J., Wu, B., Gao, F., Tien, P., Rao, Z. & Gao*, G.F. , 2003, Crystallization and preliminary X-ray diffraction analysis of post-fusion 6-helix bundle core structure from Newcastle disease virus F protein. Acta Crystallographica Section D Biological Crystallography D59: 1296-1298.
53. Zhu, J., Li, P., Wu, T., Gao, F., Ding Y., Zhang, C.W.-H., Rao, Z., Gao*, G.F. & Tien*, P., 2003, Design and analysis of post-fusion 6-helix bundle of heptad repeat regions from Newcastle disease virus F protein. Protein Engineering 16: 373-379. *Shared correspondence author.
54. Zhu, J., Zhang, C.W.-H., Rao, Z., Tien, P. & Gao*, G.F. , 2003, Biochemical and biophysical analysis of heptad repeat regions from the fusion protein of Menangle virus, a newly emergent paramyxovirus. Archives of Virology 148: 1301-1316.
55. Gao,* G.F. , Rao, Z. & Bell, J.I., 2002, Molecular coordination of cβ T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands. Trends in Immunology 23: 408-413. *Correspondence author
56. Gao, G.F ., 2002, CD8cc and CD8 cβ: truly different? (News and comment). Trends in Immunology 23: 177.
57. Gao, G.F. & Rao, Z., 2002, Seeing the change: TCR binds pMHC with an ‘induced-fit' (News and comment). Trends in Immunology 23: 281.
58. Rao, Z. & Gao, G.F. , 2002, Lipid-antigen presentation by CD1 is crystal clear (News and comment). Trends in Immunology 23: 473.
59. Jiang, S., Borthwick , N.J. , Morrison, P., Gao, G.F. & Steward, M.W., 2002, Virus-specific CTL responses induced by an H-2Kd-restricted, motif-negative 15-mer peptide from the fusion protein of respiratory syncytial virus . Journal of General Virology 83: 429-438.
60. Yu, M., Wang, E., Liu, Y., Cao, D., Jin, N., Zhang, C.W.-H, Bartlam, M., Rao, Z., Tien, P. & Gao*, G.F. , 2002, Six-helix bundle assembly and characterization of heptad repeat regions from the F protein of Newcastle disease virus . Journal of General Virology 83: 623-629.
61. Zhu, J., Zhang, C.W.-H., Qi, Y., Tien, P. & Gao*, G.F. , 2002, The fusion protein core of measles virus forms stable coiled coil trimer. Biochemical and Biophysical Research Communications (BBRC) 299: 897-902.
62. Meng, S.-D., Song, J., Rao, Z., Tien, P. & Gao*, G.F. , 2002, Three-step purification of gp96 from human liver tumor tissues suitable for isolation of gp96-bound peptides. Journal of Immunological Methods 264: 29-35.
63. Meng, S.-D., Gao, T., Gao*, G.F. & Tien*, P., 2001, HBV-specific peptide associated with heat-shock protein gp96. The Lancet 357: 528-529. *Shared correspondence author
64. Lin, C.-L., Sewell, A.K., Gao, G.F. , Whelan, K., Phillips, R.E. & Austyn, J.M., 2000, Macrophage-tropic HIV induces and exploits dendritic cell chemotaxis. Journal of Experimental Medicine 192: 587-593.
65. Gao, G.F. , Willcox, B.E., Wyer, J.R., Boulter, J.M., O'Callaghan, C.A., Maenaka, K., Stuart, D.I., Jones, E.Y., van der Merwe, P.A., Bell, J.I. & Jakobsen, B.K., 2000, Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8αα Journal of Biological Chemistry (JBC) 275: 15232-15238.
66. Gao,* G.F. & Jakobsen, B.K., 2000, Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunology Today 21 (12): 630-636. *Correspondence author
67. Sewell, A.K., Gerth, U.C., Price, D.A., Purbhoo, M.A., Boulter, J.M., Gao, G.F. , Bell, J.I., Phillips, R.E. & Jakobsen, B.K., 1999, Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5: 399-404.
68. Wyer* J.R., Willcox*, B.E., Gao*, G.F. , Gerth, U.C., Davis, S.J., Bell, J.I., van der Merwe, P.A. & Jakobsen, B.K., 1999, T cell receptor and coreceptor CD8 a a bind peptide-MHC independently and with distinct kinetics. Immunity 10: 219-225. *Shared first author
69. Maenaka, K., Juji, T., Nakayama, T., Wyer, J.R., Gao, G.F. , Maenaka, T., Zaccai, N.R., Kikuchi, A., Yabe, T., Tokunaga, K., Tadokoro, K., Stuart, D.I., Jones, E.Y. & van der Merwe, P.A., 1999, Killer cell immunoglobulin receptors and T cell receptors bind peptide-Major Histocompatibility Complex class I with distinct thermodynamic and kinetic properties. Journal of Biological Chemistry (JBC) 274: 28329-28334.
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