唐宏 中国科学院分子发育生物学重点实验室 副主任
唐宏 研究员，博士生导师
中国科学院分子发育生物学重点实验室 副主任
中国科学院生物物理研究所 生物大分子国家重点实验室 副主任
1988年 南京大学生物化学系 学士
1996年 美国Rutgers大学及Robert Wood Johnson医学院分子遗传与微生物学 博士
1996年 美国麻省理工学院 博士后
2000年 美国Dupont Pharmaceutical Company 高级研究员。
2001年 中国科学院微生物研究所 研究员，博导。
2005年 中科院生物物理所 感染与免疫中心 研究员，博导。
电子邮件：tanghong@moon.ibp.ac.cn
研究方向
主要研究高等动物淋巴细胞发育以及炎症反应中的信号转导机制，淋巴细胞基因表达的表观遗传调控机理，病毒感染的天然免疫机制。
代表性论文
Tang, H., Severinov, K., Goldfarb. A., Fenyo, D., Chait. B., and Ebright, R. (1994) Location, structure and function of the target of a transcription activator protein. Genes & Dev. 8, 3058-3067.
Blatter, E., Ross, W., Tang, H., Gourse, R., and Ebright, R. (1994) Domain organization of RNA polymerase α subunit: C-terminal 85 amino acid constitute a domain capable of dimerization and DNA binding. Cell 78, 889-896.
Tang, H., Severinov, K., Goldfarb, A., and Ebright, R. (1995) Rapid RNA polymerase genetics: one-day, no-column preparation of reconstituted recombinant Escherichia coli RNA polymerase. Proc. Natl. Acad. Sci. USA 92, 4902-4906.
Tang, H., Sun, X., Reinberg, D., and Ebright, R. (1996) Protein-protein interactions in eukaryotic transcription initiation: structure of the pre-initiation complex. Proc. Natl. Acad. Sci. USA 93, 1119-1124.
Tang H and Sharp PA (1999) Transcriptional regulation of the murine 3' IgH enhancer by Oct-2. Immunity 11, 517-26.
He HZ, Ding Y, Bartlam M, Sun F, Le Y, Qin XC, Jiang F, Liu YW, Tang H., Liu JY, Zhao NM and Rao ZH (2003) Mechanism for β-lactam and protein acetylation revealed by the crystal structure of Tabtoxin Resistance protein, a GCN5-related N-acetyltransferase, complexed with acetyl coenzyme A. J Mol Biol. 325, 1019–30.
Chen H, Tang H and Ebright RH (2003) Functional Interaction between RNA Polymerase α subunit C-Terminal Domain and б70 UP-Element-and Activator-Dependent Transcription. Mol Cell，11(6):1621-33.
Shi Y, Chen JJ, Weng CJ, Chen R, Zheng YH, Chen Q and Tang H (2003), Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins, Biochem Biophys Res Comm 305:989-96.
Zheng Y., Shi Y., Tian C., Jiang C., Jin H., Chen J., Almasan A., Tang H. and Chen H.(2004) Essential Role of the Voltage-dependent Anion Channel (VDAC) in Mitochondrial Permeability Transition Pore Opening and Cytochrome C Release Induced by Arsenic Trioxide. Oncogene, 23:1239-47.
Kang X., Xu Y., Wu X., Liang Y., Wang C., Guo J. Wang Y., Chen M., Wu D., Wang Y., Bi S., Qiu Y., Lu P., Cheng J., Xiao B., Hu L., Gao X., Liu J., Wang Y., Song Y., Zhang L., Suo F., Chen T., Huang Z., Zhao Y., Lu H., Pan C. and Tang H (2005) Proteomic Fingerprints for Potential Application to Early Diagnosis of Severe Acute Respiratory Syndrome. Clin Chem 51(1): 56-64.
Weng C, Li Y, Xu D, Shi Y, Tang H (2005) Specific cleavage of Mcl-1 by caspase-3 in TRAIL- induced apoptosis in Jurkat leukemia T cells. J Biol Chem., 280:(11) 10491–10500.
Perry AK, Chen G, Zheng DH, Tang H and Cheng G (2005) The host type I interferon response to viral and bacterial infections. Cell Res, 15(6):407-422.
Qin, X. and Tang, H. (2006) Concerted regulation of chromatin structure of both the murine 3’ IgH enhancer and Igγ2b promoter in response to LPS and CD40 signaling. Mol Immunol 43:1211–1220.
