实验室负责人照片:
欧阳宏伟 浙江大学医学院干细胞与组织工程实验室 学科带头人
欧阳宏伟
职称:教授、博士生导师[运动医学(创伤修复)， 细胞生物学]
联系：Email hwoy@zju.edu.cn Phone/ Fax 0571-88208262
教育背景：
1994 湖南医科大学（现中南大学湘雅医学院）临床医学本科
1999 湖南医科大学第一附属湘雅医院临床骨科学直博
2002 新加坡国立大学医学院骨科组织工程博士学位
研究方向：
干细胞生物学和技术
肌腱软骨修复再生科学问题和组织工程学技术
干细胞和组织工程技术的临床化、产业化研究
学术/社会团体兼职：
国际软骨修复学会亚洲组委员
中国组织工程学会委员
国际学术期刊的编委(Asian Pacific Journal of life Science)
国际学术期刊审稿人(Journal of Othorpedic research, Journal of biotechnology and bioengineering, Tissue Engineering, etc).
浙江大学细胞生物学研究所 副所长
浙江大学医学院组织工程中心 副主任
近期国际学术声誉（Invited Review & Keynote lecture)：
2007年6月获国际学术期刊Frontiers In Bioscience Journal（3.6）邀请写综述（Invited Review)
2006年11月： ICRS workshop and combined orthopedic meeting in Singapore （新加坡Keynote lecture）
2007年9月： UK international workshop combined showcase meeting on tissue engineering（英国Keynote lecture）
2007年12月： 3rd Australian biotherapeutics&tissue regeneration forum （澳大利亚Keynote lecture）
2008年4月：5th World Congress of Sports Trauma (WCST), International Symposium of Tendons & Ligaments (ISL&T)（香港Keynote lecture）
主要专业成果、文章、专利：
回国前以（临床科学家）身份带领新加坡国立大学附属医院临床组织工程小组和东南亚唯一的临床组织工程实验室。已完成近百例临床组织工程治疗，为华人的骨关节再生提供了第一批临床资料。
回国后在浙江大学期间，在中国最先开展了关键技术完全本土化的临床自体软骨细胞移植治疗。
专著专利：
1. Ouyang HW, Toh SL, Goh JCH, Tay TE, Nhan PT. Novel Method for Engineering Connective Tissues. 美国专利序号Serial no. 60/670,130；
2. 欧阳宏伟 一种制备血小板富集血浆的装置及制备方法。专利号 ZL200410026230.1；
3. 欧阳宏伟 一种网状组织工程支架。申请号 200610051885.3；
4. 欧阳宏伟 一种软骨组织工程支架及应用。申请号 200710068762.5
5. 欧阳宏伟 一种膜状组织工程支架及应用。申请号 200710068761.0
6. 英文专著 Goh JCH, Ouyang HW Chapter 22: Ligament and tendon repair with adult stem cells in « STEM CELLS: FROM BENCH TO BEDSIDE » published by WORLD SCIENTIFIC PUBLISHING CO.
近5年来在国际权威专业期刊上发表国际论文近30篇，被引210多次。
2. Qi YY, Zou XH, Cai HX, Chen X, Song XH, Wang LL, Ouyang HW Autologous platelet rich plasma (PRP) in collagen matrix significantly improved the efficacy of microfracture for articular cartilage repair. Osteoarthritis & Cartilage Submitted
3. Cai YZ , Qi YY, Cai HX, Zou XH, Wang LL, Ouyang HW * Electrospinning nanofibrous membrane with microporous matrix guided large bone defect regeneration in rabbit model. J Biomed Mat Res Submitted
4. Chen X , Zou XH, Yin GL, Ouyang HW Tendon tissue engineering with mesenchymal stem cells and biografts: An option for large tendon defects? Frontiers in Bioscience In press
5. Ouyang HW, Cao T, Zou XH, et al.Mesenchymal stem cell sheets revitalize nonviable dense grafts: Implications for repair of large-bone and tendon defects TRANSPLANTATION 82 (2): 170-174 JUL 27 2006
6. Sahoo S, Ouyang H, Goh JCH, et al.Characterization of a novel polymeric scaffold for potential application in tendon/ligament tissue engineering TISSUE ENG 12 (1): 91-99 JAN 2006
7. Wu YN, Yang Z, Hui JH, Ouyang HW, Lee EH.Cartilaginous ECM component-modification of the micro-bead culture system for chondrogenic differentiation of mesenchymal stem cells. Biomaterials. 2007 Jun 22; [Epub ahead of print]
8. Ouyang HW, Toh SL, Goh J, et al.Assembly of bone marrow stromal cell sheets with knitted poly (L-lactide) scaffold for engineering ligament analogs J BIOMED MAT RES 75B (2): 264-271 NOV 2005
9. Zhang YZ, Ouyang HW, Lim CT, et al.Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds J BIOMED MAT RES 72B (1): 156-165 JAN 15 2005
10. Afizah H, Yang Z, Hui JHP, Ouyang HW.A comparison between the chondrogenic potential of human bone marrow stem cells (BMSCs) and adipose-derived stem cells (ADSCs) taken from the same donors TISSUE ENG 13 (4): 659-666 APR 2007
11. Ouyang HW, Goh JCH, Thambyah A, et al.Knitted poly-lactide-co-glycolide scaffold loaded with bone marrow stromal cells in repair and regeneration of rabbit Achilles tendon TISSUE ENG 9 (3): 431-439 JUN 2003
12. Goh JCH, Ouyang HW, Teoh SH, et al.Tissue-engineering approach to the repair and regeneration of tendons and ligaments TISSUE ENG 9: S31-S44 Suppl. 1 2003
13. Ng CKF, Ouyang HW, Goh JCH, et al.Comparative investigation of cell surface markers for isolation of human adipose tissue derived stem cells in vitro TISSUE ENG 12 (4): 1112 380 APR 2006
14. Hui JHP, Li L, Teo YH, Ouyang HWet al.Comparative study of the ability of mesenchymal stem cells derived from bone marrow, periosteum, and adipose tissue in treatment of partial growth arrest in rabbit TISSUE ENG 11 (5-6): 904-912 MAY 2005
15. Wang Z, Goh J, Das De S, Ge Z, Ouyang H, Chong JS, Low SL, Lee EH.Efficacy of bone marrow-derived stem cells in strengthening osteoporotic bone in a rabbit model.Tissue Eng. 2006 Jul;12(7):1753-61.
16. Ouyang HW, Goh JCH, Mo XM, et al.Characterization of anterior cruciate ligament cells and bone marrow stromal cells on various biodegradable polymeric films MAT SCI & ENG C 20 (1-2): 63-69 Sp. Iss. SI MAY 31 2002
17. Ouyang HW, Goh JCH, Mo XM, et al.The efficacy of bone marrow stromal cell-seeded knitted PLGA fiber scaffold for Achilles tendon repair ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 961: 126-129 2002
18. Ouyang HW, Goh JCH, Lee EHViability of allogeneic bone marrow stromal cells following local delivery into patella tendon in rabbit model CELL TRANSPLANTATION 13 (6): 649-657 2004
19. Ouyang HW, Goh JCH, Lee EHUse of bone marrow stromal cells for tendon graft-to-bone healing - Histological and immunohistochemical studies in a rabbit model AMERICAN JOURNAL OF SPORTS MEDICINE 32 (2): 321-327 MAR 2004
20. Hui JHP, Ouyang HW, Hutmacher DW, et al.Mesenchymal stem cells in musculoskeletal tissue engineering: A review of recent advances in National University of Singapore ANNALS ACADEMY OF MEDICINE SINGAPORE 34 (2): 206-212 MAR 2005
21. Liu H, Kemeny DM, Heng BC, Ouyang HWet al.The immunogenicity and immunomodulatory function of osteogenic cells differentiated from mesenchymal stem cells JOURNAL OF IMMUNOLOGY 176 (5): 2864-2871 MAR 1 2006
22. Chen FL, Ouyang H, Feng X, et al.Anchoring dental implant in tissue-engineered bone using composite scaffold: A preliminary study in nude mouse model JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 63 (5): 586-591 MAY 2005
23. Chen F, Feng X, Wu W, Ouyang H,et al.Segmental bone tissue engineering by seeding osteoblast precursor cells into titanium mesh-coral composite scaffolds
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 36 (9): 822-827 SEP 2007
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 36 (9): 822-827 SEP 2007
24. Wu W, Feng X, Mao T, Feng X, Ouyang HW, Zhao G, Chen F.Engineering of human tracheal tissue with collagen-enforced poly-lactic-glycolic acid non-woven mesh: a preliminary study in nude mice.Br J Oral Maxillofac Surg. 2007 Jun;45(4):272-8. Epub 2006 Nov 13.
25. Heng BC, Phan TT, Liu H, Ouyang HWet al.Can the therapeutic advantages of allogenic umbilical cord blood-derived stem cells and autologous bone marrow-derived mesenchymal stem cells be combined and synergized? ASAIO JOURNAL 52 (6): 611-613 NOV-DEC 2006
26. Heng BC, Ye CP, Liu H, Ouyang HWet al.Loss of viability during freeze-thaw of intact and adherent human embryonic stem cells with conventional slow-cooling protocols is predominantly due to apoptosis rather than cellular necrosis JOURNAL OF BIOMEDICAL SCIENCE 13 (3): 433-445 MAY 2006
27. Zou XH, Foong WC, Cao T, Ouyang HWet al.Chondroitin sulfate in palatal wound healing JOURNAL OF DENTAL RESEARCH 83 (11): 880-885 NOV 2004
28. Ge ZG, Hu Y, Heng BC, Ouyang H,.Osteoarthritis and therapy ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH 55 (3): 493-500 JUN 15 2006
29. Cao T, Shi Z, Liu H, Ouyang H,.Osteogenic and chondrogenic lineage differentiation of mesenchymal stem cells in 3D culture with a novel scaffold. JOURNAL OF DENTAL RESEARCH 82: B108 0770 Sp. Iss. B JUN 2003
30. Liu H, Cao T, Saw TY, Ouyang H,.Allogenic immunogenicity of mesenchymal stem cell and its differentiated osteogenic lineage. JOURNAL OF DENTAL RESEARCH 82: B219 1660 Sp. Iss. B JUN 2003
31. Zou XH, Foong KWC, Yip GW, Ouyang HWet al.The inhibition of sulfated glycosaminoglycans on cultured palatal fibroblast behavior. JOURNAL OF DENTAL RESEARCH 82: B25 0101 Sp. Iss. B JUN 2003
32. 齐义营，施培华，欧阳宏伟.自体软骨细胞移植治疗关节软骨缺损的最新临床进展。中华骨科杂志 2008年第一期。
现承担的课题：
1. 工程化间质干细胞低表达V型胶原促损伤肌腱完全再生研究.国家青年自然科学基金 2007。1-2009，12； 主持人30600301
2. 运动创伤中韧带肌腱修复的关键科学问题研究 国家自然科学基金委-广东省联合基金 2007，1-2009，12； ，主持人 U0672001
3. 软骨组织工程关键技术和产业化研究 浙江省科技厅重大重点项目 2006，7-2009，6； 主持人 2006C13084
4. 再生医学人类种子干细胞技术的研究和开发 浙江省科技厅国际合作重点项目 2006，7-2009，3； 主持人 2006C14024
5. 干细胞复合组织工程原理治疗妇女尿失禁 国家青年自然科学基金 2007，1—2009，12；第一合作人
6. 再生医学材料和组织工程 浙江大学交叉预研重点项目子科题 2006-2007； 主持人
7. 人体软骨细胞生产 龙禧企业重点横向项目 2006-2007 主持人
省人才基金欧阳宏伟研究小组R206016
