Zhirong SUN, Professor

Zhirong Sun obtained his BS from Tsinghua University in 1970. He became a lecturer in the Automation Department of Tsinghua University after graduation. He has taught in the Department of Biological sciences & Technology, Tsinghua University since 1984. He became an associate professor in Bioinformatics in 1990. He has been a full professor since 1998. He was a Visiting Scientist at Birkbeck College in 1992-1993, and a Visiting Scientist in UIUC in 1997-1998.

Research Interests

The research interests of Professor Sun are mainly in the field of bioinformatics. His research projects have been directed towards

1) protein structure prediction and drug molecular design;
2) protein subcellular location;
3) molecular evolution;
4) microarray data mining;
5) transcription factor database construction and analysis;
6) gene function prediction and genome research;
7) Genome analysis.

Selected Publications

Zi Z, Cho KH, Sung MH, Xia X, Zheng J, Sun Z. In silico identification of the key components and steps in IFN-gamma induced JAK-STAT signaling pathway. FEBS Lett. 2005 Feb 14;579(5):1101-8.
Xinglai Ji, Yuan Yuan, Jesse Li-Ling, Yanda Li and Zhirong Sun. (2004) HMMGEP: clustering gene expression data using hidden Markov models. Bioinformatics. Bioinformatics Advance Access published on February 26, 2004.DOI: 10.1093/bioinformatics/bth145.
Tao Guo, Sujun Hua, Xinglai Ji and Zhirong Sun*, DBSubLoc: database of protein subcellular localization. Nucleic Acids Research. 2004 Jan 1;32 Database issue:D122-4.
Shuqun Liu, Shixiu Fan, Zhirong Sun*, Characterize dynamic conformational space of human CCR5 extracellular domain by molecular modeling and molecular dynamics simulation2003. J. of Molecular Modeler, 2003, Vol. 9, No. 5.
LIU Shuqun*, GUO Tao*, JI Xinglai & SUN Zhirong. Bioinformatical study on the proteomics and evolution of SARS-CoV. Chinese Science Bulletin 2003. Vol. 48. No. 13, 1277-1286.
Jian Guo, Hu Chen and Zhirong Sun*, A novel method for secondary structure prediction using dual-layer SVM and Profiles. Protein: Structure, Function and Genetics. 2004 54(4),738-43
Zheng J, Wu J, Sun Z.An approach to identify over-represented cis-elements in related sequences. Nucleic Acids Res 2003 Apr 1;31(7):1995-2005
Tsai L, Luo L, Sun Z. Sequence-dependent flexibility in promoter sequences. J. Biomol. Stuct. Dyn. 2002 Aug, 20(1): 127-34.
Bao L, Sun Z. Identifying genes related to drug anticancer mechanisms using support vector machine. FEBS LETTER. 2002, Jun 19, 521(1-3): 109-114.
Hua SJ, Guo T, Gough J & Sun ZR. (2002). Proteins with Class α/β Fold Have High-level Participation in Fusion Events J. Mol. Biol., 320:713-719.
Lei Bao, Tao Guo& Zhirong Sun, Mining functional relationships in feature subspaces from gene expression profiles and drug activity profiles. FEBS LETTER. 2002, 320(4), 713-719.
Lu Tsai & Zhirong Sun Dynamic Flexibility in Escherichia Coli Genome. FEBS LETTER. 2001, V507,N2: 225-230.
Hua SJ & Sun ZR. (2001). Support Vector Machine Approach for Protein Subcellular Localization Prediction. Bioinformatics, 17:721-728.
Hua SJ & Sun ZR. (2001). A Novel Method of Protein Secondary Structure Prediction with High Segment Overlap Measure: Support Vector Machine Approach. J. Mol. Biol., 308:397-407.
Ziding Zhang, Zhi-rong Sun & Chun-Ting, A New approach to predict the Helix/Strand content of globular proteins. J.Theor.Biol., 2000,208.
Zhirong Sun, Yan Cui, Lun Jing Ling, Qing Guo & Runsheng Chen. Molecular Dynamics Simulation of Protein Folding with Supersecondary Structure Constraints. J.Protein Chemistry. 1998, V17, 8: 765-769.
Lu X., Sun Z.R., Chen H. & Li Yan-da. Characterizing self-Similarity in bacteric DNA sequences. Physical Review E, 1998, N58, 1755-1765.
Sun Z.R., Xia X.F. & Xu D., Protein Structure Prediction in 210-type Lattice Model: Parameter Optimization in the Genetic Algorithm Using Orthogonal Array. J.Protein Chemistry. 1998, V17,N8, 765-769.
Bo J., Guo T., & Peng L.W. Sun Z.R. Folding Type-Specific Secondary Structure Propensities of Amino Acids, Derived from a-Helical, b-sheet, a/b and a+b Proteins of Known Structures. Biopolymer 1998 No.1,35-49.

Sun Z.R. Rao X.Q. Peng L.W. & Xu Dong. Prediction of Protein Supersecondary Structures Based on Artificial Neural Network Method. Protein Engineering. 1997 Vol.10, No.7, 763-769.

Contact:

Tel: +86-10-62772237

Fax: +86-10-62772237

E-mail: sunzhr@mail.tsinghua.edu.cn