所长：韩珉博士
-教育部长江学者特聘讲座教授
-科罗拉多大学分子、细胞和发育生物学系教授
-霍华德休斯医学研究院研究员
电话：(021) 65642111
电子邮箱:Mhan@colorado.edu
http://www.colorado.edu/MCDB/HanLab
PUBLICATIONS:
From Last Century.
Han M. Ras proteins in developmental pattern formation in Caenorhabditis elegans and Drosophila. [Review]] Seminars in Cancer Biology. 3(4):219-28, 1992 Aug. Abstract
Han M. Golden A. Han Y. Sternberg PW. C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation. Nature. 363(6425):133-40, 1993 May 13. Abstract
Sternberg PW. Golden A. Han M. Role of a raf proto-oncogene during Caenorhabditis elegans vulval development. Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences. 340(1293):259-65, 1993 Jun 29.Abstract
Han, M. (1993). Ras-mediated signaling pathway during vulval development in C. elegans. Ciba Foundation symposium 176. The GTPase superfamily. pp. 215-217.
Han, M. (1994). Common themes in different lives. Book Review on Signal Transduction- Prokaryotic and Simple Eukaryotic Systems. Bioessays 16, 445-446.
Sternberg, P. and M. Han. (1994) Let-60 ras. Guidebook to the small GTPases. (Eds., L.A. Huber, M. Zerial and J. Tooze).
Wu Y. Han M. Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation. Genes & Development. 8(2):147-59, 1994 Jan. Abstract
Wu Y. Han M. Guan KL. MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events. Genes & Development. 9(6):742-55, 1995 Mar 15. Abstract
Hara M. Han M. Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 92(8):3333-7, 1995 Apr 11. Abstract
Singh N. Han M. sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction. Genes & Development. 9(18):2251-65, 1995 Sep 15. Abstract
Sundaram M. Han M. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction . Cell. 83(6):889-901, 1995 Dec 15. Abstract
Sundaram M. Han M. Control and integration of cell signaling pathways during C. elegans vulval development. [Review] Bioessays. 18(6):473-80, 1996 Jun.
Sundaram M. Yochem J. Han M. A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans. Development. 122(9):2823-33, 1996 Sep. Abstract
Han M. and M. Sundaram (1996) Ras-mediated signal transduction pathway in C. elegans. In: Regulation of the Ras Signaling Network (H. Maruta, ed.). R.G. Landes Company, pp. 47-74.
Zhang, K., Yen, H., Han, M. & Donoso, L. A. (1996) Molecular genetics of inherited macular dystrophies. British Journal of Ophthalmology. 80(11):1018-1022, 1996 Nov.
Yochem J. Sundaram M. Han M. Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans. Molecular and Cellular Biology. 17(5):2716-2722, 1997 May. Abstract
Han M. Gut Reaction to Wnt Signaling in Worms. Cell. 90(4):581-584, 1997 Aug 22. Abstract
Sugimoto, T., Stewart, S., Han, M. and Guan, K-L (1997). The kinase suppressor of Ras (KSR) uncouples Elk-1 phosphorylation from MAP kinase activation. EMBO J17, 1717-1727.
Dent, J. and Han, M. (1998). Post-embryonic expression pattern of C. elegans let-60 ras reporter constructs. Mechanisms of Development.72, 179-182. Abstract
Gu, T. and Han, M. (1998) The C. elegans sur-5 gene negatively regulates let-60 ras activity and encodes an novel but evolutionarily conserved ATP binding protein. Mol. Cell. Biol.,18(8):4556-4564.
Kniazeva, M, Han, M. (1998). Addition of a second primer in PCR mixture after the first step of initial denaturation greatly improves synthesis of specific PCR fragments. TTO#1416, Elsevier Trends J., 1998
Yochem, J., Gu, T. and Han, M. (1998) Usage of SUR-5-GFP fusion protein as a marker to rapid DNA-mediated transformation and mosaic analysis in C. elegans. Genetics,149:1323-1334. Abstract
Sieburth, D., Qun, S., and Han, M.(1998) SUR-8,a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C.elegans. Cell. 94 (1):119-130. Abstract
Sternberg, P. and Han, M. (1998). Genetics of Ras Siganling in Caenorhabditis elegans. Trends in Genetics, 14 (11): 466-472. Abstract
Fay, D. S., Stanley, H., Han, M. and Wood, W. B. (1999) A Caenorhabditiselegans Homologue of hunchback is Required for Late Stages of Development but Not Early Embryonic Patterning. Dev. Biol. 205, 204-253. Abstract
Hanna-Rose, W. and Han, M. (1999). Cog-2, a Sox domain protein necessary for establishing the functional connection between the uterus and the vulva in Caenorhabditis elegans. Development. 126 (1), 169-179. Abstract
Yochem, J. Tuch, S., Greenwald, I. and Han, M. (1999) A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting. Development. 126 (3), 597-606. Abstract
Malone, C. J., Fixen, W. D., Horvits, H. R. and Han, M. (1999) UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. Development. 126, 3171-3181.
Kniazeva, M., Zawistovski, J., Han, M. (1998). Addition of a second primer in PCR mixture after the first step of initial denaturation greatly improves synthesis of specific PCR fragments. TTO#1416, Elsevier Trends Journals, 1998.
Zhang K, Garibaldi DC, Kniazeva M, Albini T, Chiang MF, Kerrigan M, Sunness JS, Han M, Allikmets R. (1999). A novel mutation in the ABCR gene in four patients with autosomal recessive Stargardt disease. Am J Ophthalmol. 128:720-4
Kniazeva, M., Chiang, M. F., Cutting, G. R., Han, M., Zhang, K. (1999) Clinical and genetic studies of an autosomal dominant cone-rod dystrophy with features of Stargardts disease. Ophthalmic Genetics 20, 71-81. Abstract
Kniazeva, M., Chiang, M. F., Han, M., Zhang, K. (1999) A new gene forautosomal dominant Stargardt-like disease maps to chromosome 4. Amer. J. Hum. Gen. 64, 1394-1399.
Zhang K, Kniazeva M, Han M., Dean M, Allikmets R. The ABCR Gene in Recessive and Dominant Stargardt Disease: A genetic Pathway in Macular Degeneration. Genomics, 60(2):234-237, 1999.
2000
Kniazeva M, Traboulsi EI, Yu Z, Stefko ST, Gorin MB, Shugart YY, O'Connell JR, Blaschak CJ, Cutting G, Han M, Zhang K. (2000). A new locus for dominant drusen and macular degeneration maps to chromosome 6q14. Am J Ophthalmol. 130:197-202.
Stewart, S., Sundaram, M., Zhang, Y., Lee, J., Xiong, Y. Han, M., and Guan, K-L. (1999). Kinase Suppressor of Ras (KSR) forms a multi-protein signaling complex and modulates MEK localization. MCB, 19, 5523-5534.
Li, W., Han, M. and Guan, K.L. (2000). The Leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Gen & Dev.14, 895-900.
Fay, D.S. and Han, M. (2000). The Synthetic Multivulval Genes of C. elegans: Functional redundancy, Ras-antagonism, and cell fate determination. Genesis. 26, 279-284.
Grant, K, Hanna-Rose, W. and Han, M. (2000). Sem-4 promotes Caenorhabditis elegans vulval fate determination through regulation of lin-39 hox. Devel. Biol. 224, 496-506.
Han, M. (2000). Studies on Ras-mediated signal transduction in C. elegans. In Sterm Cells and Development. Ed. By Jinseng Ye, Tian Xu, Tang Xifang and Bei
Haitial. Medical Science Press. Beijing, China.
Chen, Z. and Han, M.(2000). Building a protein interaction map:research in the post-genomic era. BioEssays,22, 503-6.
Hanna-Rose, W. and Han, M. (2000). Getting your signal crossed. Curr. Opin. in Dev. Genetics. 10, 523-528.
Fay, D. S. and Han, M. (2000). Mutations in the C. elegans cyclin E gene reveal a timing mechanism that controls vulval cell differentiation. Development, 18,4049-4060.
2001
Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ, Kakuk, LE, Lagali PS, Wong PW, MacDonald IM, Sieving PA,
Figueroa DJ, Austin CP, Gould RJ, Ayyagari R, Petrukhin K. (2001). A 5bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nature Genetics, 27, 89-93.
Yoder, J. and Han, M. (2001). Cytoplasmic dynein light intermediate is required for discrete aspects of mitosis in Caenorhabditis elegans. Mol. Cell. Biol 12, 2921-2933.
Chen, Z., Han, M. (2001) Role of C. elegans lin-40 MTA in vulval fate specification and morphogenesis. Development. 128, 4911-4921.
Starr, D, Hermann, GJ., Malone, C. Fixsen, W., Priess, J. Horvitz, HR and Han, M. (2001). unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. Development. 128, 5039-5050.
Chen, Z. and Han, M. (2001). Role of Rb/E2F, the NuRD Complex, and Ras in Regulating a lin-39 Hox-mediated Cell Fusion Process during Vulval Fate Specification in C. elegans Curr. Biol. 11, 1874-1879.
Spencer, A., Orita, S., Malone, C., and Han, M. (2001) A RHO GTPase mediated pathway is required during P cell migration in C. elegans. Proc. Natl. Acd. Sci. USA. 98, 13132-13137.
2002
Hanna-Rose, W. and Han, M. (2002). The Caenorhabditis elegans EGL-26 protein mediates vulval cell morphogenesis. Devel. Bio. 24, 247-258. (Cover illustration)
Antoshechkin, I. and Han, M. (2002). Caenorhabditis elegans evl-20 gene encodes a functional homologue of human small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis. Developmental Cell, 2, 579-591.
Starr, D. and Han, M. Role of ANC-1 in Tethering Nuclei to the Actin Cytoskeleton. Science. 298, 406-409.
Suzuki, Y., Morris, G., Han, M. and Wood, W.B. (2002). A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta signaling in determining Caenorhabditis elegans body shape. Genetics, in press.
Fay, D., Keneen, S. and Han, M. (2002) fzr-1 and lin-35/Rb Function Redundantly to Control Cell Proliferation in C. elegans as Revealed by
Nonbiased Synthetic Screen. Genes & Dev. 16. 503-517. (Cover illustration)
2003
Fay D., Large, E. Han, M. and Darland, M. (2003) lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control
pharyngeal morphogenesis in C. elegans Development.130, 3319-3330.
Kniazeva, M., Sieber, M. McCauley. S. Zhang, K. Watts, J., Han, M. (2003). Suppression of C. elegans ELO-2 function results in disruption of
palmitic acid elongation and causes multiple physiological defects including abnormal ultradian rhythms. Genetics, 163 159-169.
Starr, D and Han, M. (2003) ANChors away: an actin based mechanism of nuclear positioning. Journal of Cell Science. 15;116:211-6.
Cui, M. and Han. M. (2003) Cis Regulatory Requirements for Vulval Cell-Specific Expression of the Caenorhabditis elegans Fibroblast Growth Factor
Gene egl-17. Dev. Biol. 257, 104-116.
Wang, F., Yoder, J., Antoshechkin, I, and Han, M. (2003). C. elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in mitosis and
meiosis. MCB, 23, 7698-7707.
2004
Yoder, J.H., Chong, H., Guan, K.L, and Han, M. (2004). Modulation of KSR activity in C . elegans by Zn ions, PAR-1 kinase and PP2A phosphatase, EMBO J. 23, 111-119.
Eastburn, D. and Han, M. (2004). When Ras Signaling Reaches the Mediator (2004). Developmental Cell. 6 158-159.
Bourbon HM and 44 other authors (2004). A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14(5):553-557, 2004.
Cui, M., Fay DS and Han, M. (2004). lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans Larval Development. Genetics, 167, 1177-85
Kniazeva, M. Crawford, QT, Seiber, M., Wang, C-Y and Han, M. (2004). Mono Methyl Branched Fatty Acids play essential role in C. elegans development. PLoS Biology, 2 (9),: e257.
Chen, Z. Eastburn, D. and Han, M. (2004). C. elegans nuclear receptor nhr-25, regulates epidermal cell development. MCB, 24, 7345-7358 (Cover photo).
Li, W. Lee, J. Vikis, HG., Hoshino, A. Liu, G., Aurandts, J. Jiang, H., Fearon, ER., Han, M., Rao, Y., Hong, K., and Guan, K-L. (2004) Activation of FAK and Src are receptor proximal events required for netrin signaling. Nature Neuroscience, 7, 1213-1221.
2005
*Grady, RM., *Starr, D, Ackerman, G. Sanes, JR., and Han, M. (2005). Syne proteins anchor muscle nuclei at the neuromuscular junction. PNAS, 102, 4359-64. (*co-first authors) (with mini-review).
Del Campo, JJ., Opoku-Serebuoh, E. Issacson, AB., Tucker, M., Han, M. and Mohler WA. (2005) A single-protein fusogen in the somatic cells of C. elegans. Current Biology, 15, 413-23.
Zhu, H. ,Xu, T. Han, M., Zhuang, Y. and Wu, X. (2005) Ubiquitous expression of mRFP1 in transgenic mice. Genesis. 2:86-90.
Starr, DA and Han, M. (2005). A genetic approach to study the role of nuclear envelope components in nuclear positioning. Novartis Found
Symp. 264, 208-219.
Ding, S., Wu, X., LI, G., Han, M., Zhuang, Y., and Xu, T (2005). Efficient Transition of PB transposon in mammalian cells and mice. Cell 122, 473-483. (Cover, featured article of the issue, Mini-review).
Ding, L., Spencer, A., Morita, K. and Han, M. (2005). The developmental timing regulator AIN-1 interacts with argonaute protein ALG-1, miRISCs and may target ALG-1 to cytoplasmic P bodies in C. elegans. Mol. Cell. 19, 437-447 (featured article of the issue, Minireview in Dev Cell).
Tucker, M., Sieburt M. Morphew M. and Han, M. (2005). The Caenorhabditis elegans aristaless orthologue, arl-1, is required for maintaining the functional and structural integrity of the amphid sensor organs. MBC, 16:4695-704 (Epub 7/29/05).
Eastburn and Han, M. (2005) A gain-of-function allele of cbp-1 leads to an increase in HAT activity and antagonism of activated Ras. MCB, 25:9427-34.
Morita, K., Hirono, K. and Han, M. (2005) The C. elegans let-21/RhoGEF gene regulates the cytokinesis and migration of epidermal P cells. EMBO Report. 6, 1163-1168.
2006
Ying, M., Xu, R., Wu, Xi, Zhuang, Y. Han, M. and Xu, T. (2006). Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. JBC, 281(18):12580-6.
Suzuki, Y. and Han, M. Synthetic screen to uncover roles of daf-18/Pten in diverse processes during C. elegans development. (2006) Gen Dev 20(4):423-8.
Cui M, Kim EB, Han M. Diverse Chromatin Remodeling Genes Antagonize the Rb-Involved SynMuv Pathways in C. elegans. PLoS Genet. 2006 May 19;2(5):e74
Cui M, Chen J, Myers TR, Hwang BJ, Sternberg PW, Greenwald I, Han M. SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate
vulval induction in C. elegans. Dev Cell. 2006 May;10(5):667-72.
Yu J, Starr DA, Wu X, Parkhurst SM, Zhuang Y, Xu T, Xu R, Han M. The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. Dev Biol. 2006 Jan 15;289(2):336-45. Epub 2005 Dec 7.
Morita, K. and Han, M. (2006). Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in C. elegans.
EMBO J. 13, 5794-5804.
Eastburn, D. and Han, M. (2006). Ras signaling in C. elegans. In Ras family GTPase, Protein and cell regulation volume 4. Der, C. ed. Springer-sbm press. Pp192-226.
2007 (so far)
Zhang, X, Xu, R., Zhu, B, Wu, X, Ding, X., Duang, S., Xu, T., Zhuang, Y. and Han, M. (2007). Syne-1 and Syne-2 play critical roles in myonuclear anchorage and motor neuron innervation. Development, in press.
Cui, M. and Han, M. Role of Chromatin factors in C. elegans. A review chapter for Wormbook.com. In press.
TEXT BOOK CHAPTER:
Han, M. C. elegans genetics. A chapter for the online Genetics textbook by Virtual Text (ergito.com).
