所长：庄原博士
-复旦教授
-杜克大学免疫学系教授
电话：(021) 65642111
电子邮箱:yzhuang@duke.edu
http://www.duke.edu/~asl10
Selected Publications:
Lazorchak AS, Wojciechowski J, Dai M, Zhuang Y. (2006). E2A promotes the survival of precursor and mature B lymphocytes. J. Immunol. 177(4):2495-504. PDF File
Lazorchak AS, Schlissel MS, Zhuang Y. (2006). E2A and IRF-4/Pip Promote Chromatin Modification and Transcription of the Immunoglobulin {kappa} Locus in Pre-B Cells. Mol. Cell. Bio. 26(3):810-21. PDF File
Ding S, Wu X, Li G, Han M, Zhuang Y, Xu T. (2005). Efficient Transposition of the piggyBac (PB) Transposon in Mammalian Cells and Mice. Cell. 12;122(3):473-83.
Li H, Dai M., Zhuang Y. (2004). A T Cell Intrinsic Role of Id3 in a Mouse Model for Primary Sjogren's Syndrome. Immunity. 21(4):551-60. PDF File
Greenbaum S, Lazorchak AS and Zhuang Y. (2004) Differential Functions for the Transcription Factor E2A in Positive and Negative Gene Regulation in Pre-B Lymphocytes. J Biol Chem. 279(43):45028-35. PDF File
Zhuang Y, Jackson A, Pan L, Shen K, Dai M. (2004) Regulation of E2A gene expression in B-lymphocyte development. Mol Immunol. Mar;40(16):1165-77.
Pan L, Bradney C, Zheng B, Zhuang Y. (2004) Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. Immunology. Feb;111(2):147-54.
Bradney C, Hjelmeland M, Komatsu Y, Yoshida M, Yao TP, Zhuang Y. (2003) Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J Biol Chem. Jan 24;278(4):2370-6.
S. Greenbaum and Y. Zhuang (2002) Identification of E2A target gene in B lymphocyte development using a gene tagging-based chromatin immunoprecipitation system. Proc. Nat. Acad. Sci. USA. Nov 12;99(3):15030-35. PDF File
L. Pan, J Hanrahan, J. Li, LP. Hale, Y. Zhuang. (2002). An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. J. Immunology. Apr 15;168(8):3923-32.
RJ. Barndt, MF. Dai, and Y. Zhuang (2000). Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. Mol. Cell. Bio 20: 6677.
LH. Pan, S. Sato, JP. Frederick, X-H. Sun, and Y. Zhuang (1999). Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. Mol. Cell. Bio. 19, 5969-5980.
RJ. Barndt, MF. Dai, and Y. Zhuang (1999). A novel role for HEB downstream or parallel to the pre-TCR signal during alpha/beta thymopoiesis. J. Immunology. 163, 3331-3343.
W. Yan, A. Z. Young, VC. Soares, R. Kelley, R. Benezra, and Y. Zhuang (1997). High incidence of acute T-cell tumors in E2A-null mice and E2A/Id1 double knockout mice. Mol. Cell. Bio. 17, 7317-7327.
Y. Zhuang, PF. Cheng, and H. Weintraub (1996). B-cell development is regulated by the combined dosage of three bHLH genes, E2A, E2-2, and HEB. Mol. Cell. Bio. 16, 2898-2905.
