郑永唐 分子免疫药理学实验室 负责人
姓名：郑永唐
出生年月：1962年
籍贯：江西省兴国县
职称：研究员,博士生导师
学位：医学学士(医学专业，江西医学院，1983)
理学硕士(细胞免疫学专业，中国科学院昆明动物研究所，1989)
理学博士(病毒免疫学专业，中国科学院昆明动物研究所，1997)
一、 学习经历
1978.10 - 1983.12 江西医学院医疗系，获医学学士学位。
1986.6 - 1989. 2 中国科学院昆明动物研究所硕士研究生 ，获理学硕士学位。
硕士论文"人和猴T淋巴细胞E和TRBC受体的比较研究"。
1993.8 -1997.8 中国科学院昆明动物研究所博士生，获理学博士学位。
博士论文"核糖体失活蛋白抗人免疫缺陷病毒活性和天花粉的免疫毒理作用"。
二、 工作经历
1983.12-1986.8 江西省赣南医学院微生物学和免疫学教研室, 任助教
1989.2-1991.12 中国科学院昆明动物研究所灵长类免疫学实验室, 任研究实习员。
1991.12-1994.10 中国科学院昆明动物研究所灵长类免疫学实验室, 任助理研究员。
1996.8-1996.9 Institute of immunological Science, Hokkaido University, Visiting Scholar
1996.9-1996.10 Gunma University School of Medicine , Visiting Scholar
1999.2-1999.8 Department of Physiology, The Chinese University of Hong Kong, Associate Research / Visiting Scholar
1994.10- 2000.8 中国科学院昆明动物研究所,任副研究员。 研究所副高职评定委员会委员，硕士生导师。
1999.9-2000.12 中国科学院昆明动物研究所,任病毒免疫学学科组负责人, 博士生导师。
2000.9-2001.4 Department of Physiology, The Chinese University of Hong Kong,
Associate Research/Visiting Scholar
2002.10-2003.1 Department of Physiology, The Chinese University of Hong Kong, Associate Research/Visiting Scholar
2001.1-至今 中国科学院昆明动物研究所,任分子免疫药理学学科团组负责人,研究员, 博士生导师。
2002.5-至今 中国科学院研究生院教授
1996.2-至今 赣南医学院微生物学和免疫学教研室客座教授
2002.11-至今 解放军第三军医大学生物化学与分子生物学客座教授
2003.5-至今 中国科学院昆明动物研究所生物安全三级实验室主任
2003.9-至今 中国科学院西南基地抗病毒天然药物联合实验室副主任,研究员
三、专著及SCI论文
(一) 专著
[1] 郑永唐，贲昆龙.1998, 猴艾滋病D型逆转录病毒。现代科技综述大辞典.编委会主编。北京出版社。P2127-2128。
[2] 郑永唐，贲昆龙. 2000, 葫芦科和其他植物蛋白抗人免疫缺陷病毒作用(第31章)。天花粉蛋白(第二版，汪猷主编)。科学出版社，北京。pp377-385
[3]陈纪军、罗士德主编，王易芬，郑永唐副主编.2002，抗艾滋病病毒活性化合物。云南科技出版社。昆明。
[4] 余化霖，袁源，郑永唐。2003，神经系统的免疫学(第四篇)。认知神经科学原理与方法（马原野，王建红主编）。重庆出版社。重庆。pp155-165.
[5] 姜润生,赵荣华,张荣平,赵春景,杨鸿生,李爱民,陆林,杨波,张俊,钱金栿,张荣健,赵昱,解奉江,胡建林,郑永唐.2003,非典型肺炎与健康食品的预防作用.云南科技出版社.昆明.
[6] 刘红亮、董坚、郑永唐。2005，基因克隆的载体（第五章）。基因克隆理论与技术（王廷华、董坚、Lee PX主编）。科学出版社，pp 65-94.
SCI论文
[1] Ben, K. and Y.T.Zheng. 1991, The distinct characteristics of receptor for tree shrew red blood cell on human and macaque T lymphocytes. Primatology Today, Ehara, A. ed., pp 651-654, Elsevier Science Pubblishers B.V.
[2] Chen, Z., K. Ben, B Tian and Y.T.Zheng. Serological Survey of a Captive Macaque Colony in China for Antibodies to Simian Type D Retroviruses. J. Med.Primatol. 1992, 21:377-380.(SCI,1.178)
[3] Zheng YT, WF Zhang, KL Ben, JH Wang. In vitro immunotoxicity and cytotoxicity of trichosanthin against human normal immunocytes and lekeumia-lymphoma cells.Immunopharmacol.Immunotoxicol. 1995,17:69-79.(SCI,0.629)
[4] Zheng YT, Ben K, Jin SW. Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T lymphoid cells. Acta Pharmacol.Sin. 1999, 20(3):239-243(SCI, 1.125)
[5] Zheng YT, Ben KL, Jin SW. Anti-HIV-1 activity of trichobitacin, a novel ribosome-inactivating protein. Acta Pharmacol.Sin. 2000, 21(2):179-182(SCI, 1.125)
[6] Zheng YT, Chan WL, Chan P, Huang H,Tam SC. Enhancement of the anti-herpetic effects of trichosanthin by acyclovir and interferon. FEBS lett. 2001, 496(2-3):139-142 (SCI, 3.843)
[7] Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y. Antimicrobial peptides from the skin secretion of Chinese red belly toad Bombina maxima. Peptides， 2002, 23(3):427-435 (SCI, 2.511)
[8] Chan WL, Zheng YT, Huang H, Tam SC. Relationship between trichosanthin cytotoxicity and its intracellular concentration. Toxicology ，2002, 177(2-3):245-251 (SCI,2.691)
[9] Wang YF, Chen JJ, Yang Y, Zheng YT, Tang SZ, Luo SD. New rotenoids from Roots of Mirabilis jalapa. Helvetica Chimica Acta 2002, 85(8):2342-2348 (SCI,1.833)
[10] Wang JH, Nie HL, Tam SC, Huang H, Zheng YT(通讯作者). Anti-HIV-1 property of trichosanthin correlates with its ribosome inactivating activity. FEBS Lett. 2002, 531(2):295-298 (SCI 3.843)
[11] Wang JH, Nie HL, Huang H, Tam SC, Zheng YT(通讯作者). Independency of anti-HIV-1 activity from ribosome inactivating activity of trichosanthin. Biochem. Biophys. Res. Commun. 2003, 302(1):89-94(SCI,2.904)
[12] Zhang YJ, Wang JH, Li WH, Wang Q, Liu H, Zheng YT(通讯作者), Zhang Y. Molecular characterization of Trimeresurus stejnegeri venom L-amino acid oxidase with potential anti-HIV activity Biochem. Biophys. Res. Commun. 2003, 309:598-604. (SCI, 2.904)
[13] Wang JH, Tam SC, Huang H, Ouyang DY, Wang YY, Zheng YT(通讯作者). Site-directed PEGylation of trichosanthin retained its anti-HIV activity with reduced potency in vitro. Biochem. Biophys. Res. Commun. 2004, 317(4):965-971 (SCI,2.904)
[14] Wang Q, Wang YT, Pu SP, Zheng YT(通讯作者). Zinc coupling potentiate anti-HIV-1 activity of baicalin. Biochem. Biophys. Res. Commun. 2004, 324:605-610(SCI,2.904)
[15] Wang Q, Ding ZH, Liu JK, Zheng YT(通讯作者). Xanthohumol, a novel anti-HIV-1 agent purified from Hop Humulus lupulus. Antiviral Res. 2004, 64(3): 189-194 (SCI,3.320)
[16] Wang JS, Zheng YT, Efferth T, Wang RR, Shen YM, Hao XJ. Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities. Phytochemistry. 2005, 66:687-701 (SCI, 2.101)
[17] Xiao WL, Li RT, Li SH, Li XL, Sun HD, Zheng YT, Wang RR, Lu Y, Wang C, Zheng QT. Lancifodilactone F: A novel nortriterpenoid possessing a unique skeleton from Schisandra lancifolia and its anti-HIV activity. Organic Lett. 2005, 7(7):1263-1266 (SCI,4.195 )
[18] Wang YY, Ouyang DY, Huang H, Chan H, Tam SC, Zheng YT(通讯作者). Enhanced apoptotic action of trichosanthin in HIV-1 infected cells. Biochem. Biophys. Res. Commun. 2005,331:1075-1080. (SCI, 2.904)
[19] Xiao WL, Zhu HJ, Shen YH, Li RT, Li SH, Sun HD, Zheng YT, Wang RR, Lu Y, Wang C, Zheng QT. 2005. Lancifodilactone G: A Unique Nortriterpenoid Isolated from Schisandra lancifolia and Its Anti-HIV Activity. Org Lett. 7(11):2145-2148 . (SCI,4.195)
[20] Li RT, Han QB, Zheng YT, Wang RR, Yang LM, Lu Y, Sang SQ, Zheng QT, Zhao QS ,Sun HD. Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha, Chem Commun, 2005, (23):2936-2938. (SCI, 3.997)
[21] Zhang GH, Wang Q, Chen JJ, Zhang XM, Tam SC, Zheng YT (通讯作者). Anti-HIV-1 effect of scutellarin. Biochem. Biophys. Res. Commun.2005 334(3):812-6.
(SCI, 2.904)
[22] Liu HL, Wang YQ, Liao CH, Kuang YQ, Zheng YT(通讯作者), Su B. Adaptive Evolution of Primate TRIM5α, a Gene Restricting HIV-1 Infection. Gene.362(2005) 109-116, (SCI, IF=2.705)
[23] Dai SJ, Dou GF, Qian XH, Song HF, Tang ZM, Liu DS, Liu XW, Yang LM, Zheng YT, Liang Q. Pharmacokinetics of sifuvirtide, a novel anti-HIV-1 peptide, in monkeys by liquid chromatography tandem mass spectrometry and the comparison with inhibitory concentrations in vitro. Acta Pharmacol. Sin. 2005 Oct;26(10):1274-1280. (SCI, 1.125)
[24] Zhao Y, Jin Y, Wang JH, Wang RR, Yang LM, Lee WH, Zheng YT(通讯作者), Zhang Y. A novel heme-containing protein with anti-HIV-1 activity from skin secretions of Bufo andrewsi. Toxicon. 2005 Nov;46(6):619-24. Epub 2005 Sep 12.(SCI, 1.862)
[25] Ouyang DY, Chan H, Wang YY, Huang H, Tam SC, Zheng YT(通讯作者). An inhibitor of c-Jun N-terminal kinases (CEP-11004) counteracts the anti-HIV-1 action of trichosanthin.Biochem Biophys Res Commun. 2005 Nov 8.339(2006) 25-29 (SCI, 2.904)
[26] Xiao WL, Tian RR, Pu JX, Li X, Wu L, Lu Y, Li SH, Li RT, Zheng YT, Zheng QT, Sun HD. Triterpenoids from Schisandra lancifolia with anti-HIV-1 activity. J Nat Prod. 2006 Feb;69(2):277-9.(SCI,2.202)
[27] Wang JH, Kong J, Li W, Molchanova V, Chikalovets I, Belogortseva N, Luk'yanov P, Zheng YT(通讯作者). A beta-galactose-specific lectin isolated from the marine worm Chaetopterus variopedatus possesses anti-HIV-1 activity. Comp Biochem Physiol C Toxicol Pharmacol. 2006 Jan-Feb;142(1-2):111-7.(SCI,1.651)
[28] Qin XD, Dong ZJ, Liu JK, Yang LM, Wang RR, Zheng YT(通讯作者), Lu Y, Wu YS, Zheng QT. Concentricolide, an anti-HIV agent from the Ascomycete Daldinia concentrica. Helvetica Chemica Acta, 2006, 89:127-133 (SCI, 1.650)
[29] Zhang YX, Wang YY, Lee WH, Zheng YT, Zhang Y. Apoptotic activity of frog Bombina maxima skin albumin. Comp Biochem Physiol B Biochem Mol Biol. 2006 Feb;143(2):153-9.(SCI, 1.393)
[30] Wang RR, Gu Q, Yang LM, Chen JJ, Li SY, Zheng YT(通讯作者). Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis. J Ethnopharmacol. 2006 Apr 21;105(1-2):269-73.(SCI,1.420)
[31] Xiao WL, Yang LM, Gong NB, Wu L, Wang RR, Pu JX, Li XL, Huang SX, Zheng YT, Li RT, Lu Y, Zheng QT, Sun HD. Rubriflordilactones a and B, two novel bisnortriterpenoids from schisandrarubriflora and their biological activities. Org Lett. 2006 Mar 2;8(5):991-4.(SCI,4.195)
[32] Xiao WL, Pu JX, Chang Y, Li XL, Huang SX, Yang LM, Li LM, Lu Y, Zheng YT, Li RT, Zheng QT, Sun HD. Sphenadilactones A and B, two novel nortriterpenoids from Schisandra sphenanthera. Org Lett. 2006 Mar 30;8(7):1475-8.(SCI,4.195)
[33] Li XL, Cheng X, Yang LM, Wang RR,Zheng YT, Xiao WL, Zhao Y, Xu G, Lu Y, Chang Y, Zheng QT, Zhao QS, Sun HD. Dichotomains A and B: two new highly oxygenated phenolic derivatives from Dicranopteris dichotoma. Org Lett. 2006 Apr 27;8(9):1937-40.(SCI,4.195)
[34] Xiao WL, Huang SX, Zhang L, Tian RR, Wu L, Li XL, Pu JX, Zheng YT, Lu Y, Li RT, Zheng QT, Sun HD. Nortriterpenoids from Schisandra lancifolia. J Nat Prod. 2006 Apr;69(4):650-3.(SCI,2.202)
[35] Huang H, Chan H, Wang YY, Ouyang DY, Zheng YT, Tam SC. Trichosanthin suppresses the elevation of p38 MAPK, and Bcl-2 induced by HSV-1 infection in Vero cells. Life Sci. 2006 , 79(13):1287-92 (SCI, 2.512)
[36] Xu G, Hou AJ, Wang RR, Liang GY, Zheng YT, Liu ZY, Li XL, Zhao Y, Huang SX, Peng LY, Zhao QS. Przewalskin A: A New C (23) Terpenoid with a 6/6/7 Carbon Ring Skeleton from Salvia przewalskii Maxim. Org Lett. 2006, 8(20):4453-4456. (SCI, 4.368)
[37] Jin Y, Fotso S, Zheng YT, Sevvana M, Laatsch H, Zhang W. Halichondria sulfonic acid, a new HIV-1 inhibitory guanidino-sulfonic acid, and halistanol sulfate isolated from the marine sponge Halichondria rugosa Ridley & Dendy. Nat Prod Res. 2006, 20(12):1129-35. (SCI, 0.572)
[38] Xu G, Hou AJ, Zheng YT, Zhao Y, Li XL, Peng LY, Zhao QS. Przewalskin B, a Novel diterpenoid with an unprecedented skeleton from Salvia przewalskii Maxim. Org Lett. 2007, 9(2): 291-293. (SCI, 4.395)
[39] Li XL, Yang LM, Zhao Y, Wang RR, Xu G, Zheng YT, Tu L, Peng LY, Cheng X, Zhao QS. Tetranorclerodanes and Clerodane-Type Diterpene Glycosides from Dicranopteris dichotoma. J Nat Prod. 2007, 70(2):265-268. (SCI, 2.202)
[40] Wang YH, Tang JG, Wang RR, Yang LM, Dong ZJ, Du L, Shen X, Liu JK, Zheng YT(通讯作者). Flazinamide, a novel β-carboline compound with anti-HIV actions. Biochem. Biophys. Res. Commun. 2007, 355(4):1091-1095 (SCI, 3.0)
[41] Molchanova V, Chikalovets I, Chernikov O, Belogortseva N, Li W, Wang JH, Ouyang DY, Zheng YT, Lukyanov P. A new lectin from the sea worm Serpula vermicularis: Isolation, characterization and anti-HIV activity. Comp Biochem Physiol C Toxicol Pharmacol. 2007 145(2):184-93 (SCI, 1.651)
[42] Chen SW, Wang YH, Jin Y, Tian X, Zheng YT(通讯作者), Luo DQ, Tu YQ. Synthesis and Anti-HIV-1 Activities of Novel Podophyllotoxin Derivatives. Bioorg Med Chem Lett. 2007, 17(7):2091-2095 (SCI, 2.478)
[43] Gu Q, Wang RR, Zhang XM, Wang YH, Zheng YT, Zhou J, Chen JJ. A new benzofuranone, and anti-HIV constituents from the stem of Rhus chinensis. Planta Med. 2007,73(3):279-82 (SCI, 1.628)
[44] Zhang GL, Li N, Wang YH, Zheng YT, Zhang Z, Wang MW. Bioactive lignans from Peperomia heyneana. J. Nat. Prod. 2007,70(4):662-664 (SCI, 2.267)
[45] Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng YT, Rees HH, Lai R, Yang D, Wu J. Anti-infection peptidomics of amphibian skin. Mol Cell Proteomics. 2007; 6(5):882-894.(SCI, 9.876)
[46]Song WY, Ma YB, Bai X, Zhang XM, Gu Q, Zheng YT, Zhou J, Chen JJ. Two new compounds and anti-HIV active constituents from Illicium verum. Planta Med. 2007, 73(4):372-5.(SCI, 1.628)
[47] Xiao Wl, Li XL, Wang RR, Yang LM, Li LM, Huang SX, Pu JX, Zheng YT, Li RT, Sun HD. Triterpenoids from Schisandra rubriflora. J Nat Prod. 2007 May 10; [Epub ahead of print] (SCI, 2.267)
[48] Liu DZ, Wang F, Yang LM, Zheng YT, Liu JK. A New Cadinane Sesquiterpene with Significant Anti-HIV-1 Activity from the Cultures of the Basidiomycete Tyromyces chioneus. J Antibiot (Tokyo). 2007, 60(5):332-4. (SCI, 1.506)
[49] Cheng P, Jiang ZY, Wang RR, Zhang XM, Wang Q, Zheng YT (通讯作者), Zhou J, Chen JJ. Synthesis and biological evaluation of N-acetyl-beta-aryl-1, 2-didehydroethylamines as new HIV-1 RT inhibitors in vitro. Bioorg Med Chem Lett. 2007, 17:4476-4480 (SCI, 2.538)
[50] Xiao WL, Yang LM, Li LM, Pu JX, Huang SX, Weng ZY, Lei C, Liu JP, Wang RR, Zheng YT, Li RT, Sun HD. Sphenalactones A-D, a new class of highly oxygenated trinortriterpenoids from Schisandra sphenanthera. Tetrahedron Lett. 2007, 48:5543-5546 (SCI, 2.509)
