张礼和 教授 院士 博士生导师（药物化学）
男 汉族 1937年9月8日出生于江苏省扬州市。
1958年毕业于北京医学院药学系。1964年考取了著名有机化学家王序教授的研究生，从事硫代糖的合成研究。1981年进入美国弗吉尼亚大学化学系做访问学者。1983年回国后任药学系副系主任，从事抗肿瘤、抗病毒药物研究，先后完成了环腺苷酸（cAMP）和阿糖腺苷酸的合成, 并逐渐形成了以核酸为作用靶的药物研究方向，融合了化学、生物学、药学的进展，使实验室的工作在国内具有自己的特点。1985年任北京医科大学药学院副院长，1987年任院长, 1990年以后担任天然药物及仿生药物国家重点实验室主任。
1990年被日本星药科大学授予名誉博士学位，1991年被评为北京市爱国立功标兵， 1993年被美国密苏里－堪萨斯大学授予第十二届埃德加·斯诺教授称号, 1995年被评为卫生部有突出贡献的中青年科学家, 1995年当选中国科学院院士, 1997年任中国药学会副理事长, 1998年兼任国家自然科学基金委员会化学部主任, 2000年当选北京市先进工作者。
电话：82801700 传真：82802724 电子信箱：zdszlh@bjmu.edu.cn
代表性的文章：
1. De-Min Zhou, P.K.R.Kumar, Li-He Zhang, Kazunari Taira, Ribozyme Mechanism Revisited: Evidence against Direct Coordination of a Mg2+Ion with the pro-R Oxygen of the Scissile Phosphate in the Transition State of a Hammerhead Ribozyme-Catalyzed Reaction, J. Am. Chem. Soc., 1996 ,118(37):8969-8970
2. D-M Zhou, L-H Zhang , K. Taira, Explanation by the Double-Metal-Ion Mechanism of Catalysis for the Differential Metal Ion Effects on the Cleavage Rates of 5'-Oxy and 5'-Thio Substrates by a Hammerhead Ribozyme, Proc. Natl. Acad. Sci. USA, 1997, 94:14343-14348
3. Zhen Lei, Ling Zhang, Liang Ren Zhang, Jun Chen, Ji Mei Min and Li He Zhang, Hybrid Characteristics of Oligonucleotides Constiting of Isonucleoside 2,5-anhydro-3-(thy-min-1'-yl)-D-mannitol with different Linkage modes, Nucleic Acids Research, 2001 , 29(7):1470-1475
4. Liangren Zhang, Yunlong Zhang, Xianghua Li and Lihe Zhang, Study on the Synthesis and PKA-1 Binding Activities of 5-Alkynyl Tubercidin Analogues, Bioorganic & Medicinal Chemistry, 2002,10:907-912
5. Li-Jun Huang, Yong-Yuan Zhao, Lan Yuan, Ji-Mei Min and Li-He Zhang, Chemical Synthesis and Calcium Release Activity of N-1 Ether Strand Substituted cADPR Mimic, Bioorganic & Medicinal Chemistry Letters, 2002 , 12: 887-88
6. Chen CP, Li XX, Zhang LR, Min JM, Chan YW, Fung KP, Wang, SQ, Zhang LH, Synthesis of Antisense Oligonucleotide-Peptide Conjugate Targeting to GLUT-1 in HepG2 and MCF-7 Cells, Bioconjugate Chemistry, 2002, 13(3):525-529,
7. Jun Cheng, Liang Ren Zhang, Ji Mei Min and Li He Zhang, Studies on the Synthesis of a G-rich Octaoligonucleotide (isoT)2 ( isoG)4 (isoT)2 Consisting of Isonucleosides by the Phosphotriester Approach and Its formation of G-quartet Structure, Nucleic Acids Research, 2002, 30(13):3005-3014
8. Li Jun Huang, Li He Zhang, Synthesis and Calcium Mobilizing Evaluations of N-1 Glucosyl Substituted Cyclic Inosine Diphospha Stable Analogs of cADPR, J. Med. Chem., 2002, 45:5340-5352
9. Xin-Shen Yi and Li He Zhang, Aminoglycoside Mimetics as Small-Molecule Drugs Targeting RNA, Current Medicinal Chemistry, 2002 ,9 (9):929-939,
10. Zhu Guan, Xian-bin Tian, Liang-ren Zhang , Ji-Min Min and Li-He Zhang, Synthesis and Hybridization Properties of an Oligo-nucleotide Consisting of 1',4'-anhydro-2',5'-dideoxy-2'-(thymin-1-yl)-D-Altritol, Helv. Chim. Acta, 2002,85(5):1479-1484
