邵健忠 浙江省细胞与基因工程重点研究实验室主任
邵健忠 教授，理学博士，博士生导师
浙江大学生命科学学院
杭州市，310058
浙江大学紫金港校区生命科学学院
Tel/Fax: 86-571-88206582
E-mail: shaojz@zju.edu.cn
主要任职
1998年浙江大学新组建以来，先后任浙江大学细胞工程研究所所长，浙江省细胞与基因工程重点研究实验室主任，浙江大学生命科学学院党委书记等职。
学术职务
中国细胞生物学会常务理事，中国海洋与湖沼学会理事，浙江省细胞生物学会副理事长，浙江省免疫学会副理事长，《细胞生物学杂志》编委，《中国水产科学》编委等职。
专业与招生方向
细胞生物学，分子生物学，细胞与分子免疫学，在上述专业方向，招收硕士研究生、博士研究生和博士后。
研究方向
1. 细胞生长与分化发育：干细胞生长与分化调控；干细胞分化的细胞与分子机制；胚胎与成体干细胞组织工程。
2. 细胞与分子免疫生物学：重要免疫功能基因分子起源与进化；比较与发育免疫学；鱼类细胞与分子免疫遗传学。
学历与工作经历
1980～1987年，杭州大学生命科学学院，获学士和硕士学位。
1995～1998年，浙江大学生物科学与技术系，获理学博士学位。
1987～2000年，杭州大学和浙江大学生命科学学院讲师、副教授。
2000～至今，浙江大学生命科学学院教授、博士研究生导师。
2003～2004年，美国哈佛大学医学院，高级访问学者。
主要研究项目
国家“973”计划“重要海水养殖动物病害发生和免疫防治的基础研究”；国家“863”计划“海洋经济鱼类重要免疫抗病基因的发掘与功能研究”；国家自然科学基金“比较基因组学辅助克隆鱼类白细胞介素基因及其功能研究”；国家自然科学基金“表达序列标签和生物信息学辅助克隆鱼类新免疫功能基因”；国家自然科学基金“鱼类 g 干扰素及其基因的分子生物学性质与功能”；国家自然科学基金“鱼类干扰素基因克隆及其在衣藻中表达的研究”；国家自然科学基金“鱼类非特异性免疫因子干扰素的研究”；浙江省重大科技攻关项目“主要水产养殖品种重要免疫抗病基因开发利用及其产业化中试”；浙江省重大科技攻关项目“海洋鱼类抗菌肽基因克隆与应用研究”；浙江省自然科学基金重点项目“生物信息学辅助克隆鱼类重要免疫功能基因及其功能研究”；浙江省重大科技攻关项目“人胚胎干细胞体外扩增与定向分化及其临床应用研究”；卫生部和浙江省联合重大攻关项目“骨髓造血和间充质干细胞跨越分化肝细胞的研究”等。
主要学术成果：
（1）在细胞与分子免疫学研究方向，通过建立鱼类比较基因组学等生物信息学技术，分离鉴定了一批关键鱼类免疫功能基因，系统研究了鱼类干扰素、白细胞介素、细胞因子受体家族、免疫球蛋白等的生物学性质与功能，揭示了鱼类免疫系统的多样性；系统开展了脊椎动物重要免疫功能基因的分子进化研究，阐明了细胞信号转导抑制因子和白细胞介素及其受体家族等的分子起源与进化规律；（2）在干细胞生长与分化研究方向，建立了细胞因子组合和组蛋白去乙酰化酶抑制剂等诱导胚胎、造血和间充质干细胞体外定向分化肝、心肌、骨细胞等技术体系，较系统地研究了染色质修饰等表观遗传机制与干细胞分化发育的关系以及成体干细胞跨越胚层分化中核基因重编程的分子机制；（3）上述研究在国内外重要学术刊物发表论文80余篇，出版《细胞生物化学原理》、《细胞工程》等专著5部，有关成果获“浙江省高校科技进步一等奖”、“浙江省科技进步优秀奖”、“浙江省医药卫生科技创新二等奖”、“杭州市优秀新产品新技术一等奖”等奖励，申报了多项国家发明专利。
近期主要论文（SCI）
2007年
1.Qing-Jun Zhou, Ye-Dan Huang，Li-Xin Xiang, Jian-Zhong Shao*, In vitro differentiation of embryonic stem cells into hepatocytes induced by fibroblast growth factors and bone morphological protein-4. International Journal of Biochemistry & Cell Biology. 2007, 39: 1714-1721. (IF 4.804)
2.Yong-Tao Xiao, Li-Xin Xiang, Jian-Zhong Shao*, Vacuolar H+-ATPase. International Journal of Biochemistry & Cell Biology. 2007, online (IF 4.804)
3.Hong-Jian Jin, Jian-Zhong Shao*, Li-Xin Xiang, Identification and characterization of suppressor of cytokine signaling 3 (SOCS-3) homologues in teleost fish, Molecular Immunology, 2007, 44:1042-1051.（IF 4.768）
4.Ja-Hui Li, Jian-Zhong Shao*, Li-xin Xiang, Cloning, characterization and expression analysis of pufferfish interleukin-4 cDNA: the first evidence of Th2-type cytokine in fish. Molecular Immunology, 2007, 44:2078-2086.（IF 4.768）
5.Hong-Jian Jin, Jian-Zhong Shao*, Li-Xin Xiang*, Hao Wang, Li-Li Sun, Global identification and comparative analysis of SOCS genes in fish: Insights into the molecular evolution of SOCS family. Molecular Immunology, 2007, online（IF 4.768）
6.Ye Chen, Xue-Jun Dong, Guo-Rong Zhang, Jian-Zhong Shao*, Li-Xin Xiang, In vitro differentiation of mouse bone marrow stromal stem cells into hepatocytes induced by conditioned culture medium of hepatocytes, Journal of Cellular Biochemistry. 2007, 102:52-63.（IF 3.591）
7.Qing-Jun Zhou, Li-Xin Xiang, Jian-Zhong Shao*, In vitro differentiation of hepatic progenitor cells from mouse embryonic stem cells induced by sodium butyrate. Journal of Cellular Biochemistry, 2007, 100:29-42.（IF 3.591）
8.Hong-Jian Jin, Jian-Zhong Shao*, Li-Xin Xiang*, Molecular cloning and identification of macrophage migration inhibitory factor (MIF) in teleost fish, Developmental and Comparative Immunology, 2007, online (IF 3.261)
9.Yong-Tao Xiao, Li-Xin Xiang, Jian-zhong Shao*, Bone morphogenetic protein. Biochemical & Biophysical Research Communication, 2007, 362:550-553. (IF 2.855)
10.Hong-Jian Jin, Li-Xin Xiang, Jian-Zhong Shao*, Identification and characterization of suppressor of cytokine signaling 1 (SOCS-1) homologues in teleost fish. Immunogenetics, 2007, 59:673-686. (IF 2.852)
11.Qing-Xiao Zhao, Jian-zhong Shao, Wei Chen, Yi-Ping Li, Osteoclast differentiation and gene regulation. Frontiers in Bioscience, 2007, 12:2519-2529. ( IF 2.771)
12.Wei Huang, Su-Yun Yang, Jian-Zhong Shao, Wei Chen, Yi-Ping Li, Signaling and transcriptional regulation in osteoblast commitment and differentiation. Frontiers in Bioscience, 2007, 12: 3068-3092. (IF 2.771)
13.Wei-Ren Dong, Li-Xin Xiang, Jian-zhong Shao*, Cloning and characterization of two natural killer enhancing factor genes (NKEF-A and NKEF-B) in pufferfish, Tetraodon nigroviridis, Fish and Shellfish Immunology, 2007, 22:1-15.（IF 2.725）
14.Wei Fang, Jian-Zhong Shao*, Li-Xin Xiang, Molecular cloning and characterization of IL-15Rα gene in rainbow trout (Oncorhynchus mykiss), Fish and Shellfish Immunology, 2007, 23:119-127.（IF 2.725）
15.Yin Chen, Li-Xin Xiang, Jian-Zhong Shao*, Construction of a recombinant plasmid containing multi-copy CpG motifs and its effects on the innate immune responses of aquatic animals. Fish and Shellfish Immunology, 2007, 23:589-600.（IF 2.725）
16.Wei Chen, Shu-Ying Yang, Yoke Abe, Ming Li, Yu-Cheng Wang, Jian-zhong Shao, En Li, Yi-Ping Li, Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence, Human Molecular Genetics, 2007, 16: 410–423. (IF 8.099)
2006年
17.Hui-Ju Wang, Li-Xin Xiang, Jian-zhong Shao*, Jia Shen, Molecular cloning, characterization and expression analysis of an IL-21 homologue from Tetraodon nigroviridis, Cytokine, 2006, 35:126-134. ( IF 2.355)
18.Yi Wen, Jian-zhong Shao*, Li-xin Xiang, Cloning, characterization and expression analysis of two Tetraodon nigroviridis interleukin-16 isoform genes, Comparative Biochemistry and Physiology: Part B-Biochemistry & Molecular Biology, 2006, 144:159-166. ( IF 1.532)
19.Hui-Fang Lin, Jian-Zhong Shao*, Li-Xin Xiang, Molecular cloning, characterization and expression analysis of grass carp (Ctenopharyngodon idellus) NF45 (ILF2) cDNA, a subunit of the nuclear factor of activated T-cells (NF-AT), Fish and Shellfish Immunology, 2006, 21:385-392. (IF IF 2.725)
20.Xu-Tao Hong, Li-Xin Xiang, Jian-zhong Shao*, The immunostimulating effect of bacterial genomic DNA on the innate immune responses of bivalve mussel, Hyriopsis cumingii Lea, Fish and Shellfish Immunology, 2006, 21:357-364. (IF 2.725)
21.Xin-Mei Liu, Jian-Zhong Shao*, Li-Xin Xiang, Xiao-Yong Chen, Cytotoxic effects and apoptosis induction of atrazine in a grass carp (Ctenopharyngodon idellus) cell line, Environmental Toxicology, 2006, 21: 80-89. (IF 1.582)
22.Xiao-Yong Chen, Jian-Zhong Shao*, Li-Xin Xiang, Xin-Mei Liu, Involvement of apoptosis in malathion-induced cytotoxicity in a grass carp (Ctenopharyngodon idellus) cell line, Comparative Biochemistry and Physiology: Part C-Toxicology & Pharmacology, 2006, 142: 36-45. ( IF 1.991)
23.Wei Fang, Li-Xin Xiang*, Jian-Zhong Shao*, Yi Wen, Shu-Yun Cheng, Identification and characterization of an interleukin-15 homologue from Tetradon nigroviridis, Comparative Biochemistry and Physiology, Part B-Biochemistry & Molecular Biology, 2006, 143:335-343. ( IF 1.532)
24.Ye Chen, Jian-Zhong Shao*, Li-Xin Xiang, Cyclic adenosine 3 ', 5 '-monophosphate induces differentiation of mouse embryonic stem cells into cardiomyocytes, Cell Biology International. 2006, 30: 301-307. ( IF 1.363)
25.Ye Chen, Xue-Jun Dong, Guo-Rong Zhang, Jian-zhong Shao*, Li-Xin Xiang, Transdifferentiation of mouse BM cells into hepatocyte-like cells. Cytotherapy, 2006, 8:381-389. (IF 2.165)
26.Hui-Ju Wang, Jian-Zhong Shao*, Li-Xin Xiang, Jia Shen, Molecular Cloning, Characterization and Expression Analysis of an ILF2 Homologue from Tetraodon nigroviridis, Journal of Biochemistry and Molecular Biology, 2006, 39:686~695. ( IF 1.548)
27.Ye Chen, Jian-Zhong Shao*, Li-Xin Xiang, Xue-Jun Dong, Guo-Rong Zhang, Transdifferentiation of bone marrow derived cells into hepatocytes in vitro. The 5th Asian-Pacific Organization for Cell Biology Congress, Abstract Collection, Cell Research, 2006, 16:S54-72. (IF 3.426)
2005~2001年
28.Yi-Ping Li, Yoke Abe, Rei Isoda, Rore Moroi, Shu-Ying Yang, Jian-Zhong Shao, En Li, Wei Chen, Cathepsin K-deficient mice exhibit pycnodysostosis geatures due to loss of cathepsin K-mediated osteoclast senescence for bone homeostasis. Journal of Bone and Mineral Research, 2005, 20: S253-253. (IF 6.527)
29.Yi Wen, Jian-Zhong Shao*, Xue-Xia Pan, Li-Xin Xiang, Molecular cloning, characterization and expression analysis of QM gene from grass carp (Ctenopharyngodon idellus) homologous to Wilms’ tumor suppressor, Comparative Biochemistry and Physiology: Part B-Biochemistry & Molecular Biology, 2005, 141:356-365. (IF 1.532)
30.Qing-Jun Zhou, Jian-Zhong Shao*, Li-Xin Xiang, Generation of embryoid bodies from mouse embryonic stem cells cultured on STO feeder cells, Cell Biology International, 2005, 29: 817-825. (IF 1.363)
31.Jian-Zhong Shao* and Li-xin Xiang, Aeromonas hydrophila induces apoptosis in carassius auratus lymphocytes in vitro, Aquaculture, 2004, 229:11-23. (IF 2.081)
32.Qing-Jun Zhou, Ruo-Zhen Hu, Jian-Zhong Shao*, Li-Xin Xiang, Notch signaling and signal tansduction, Progress in Biochemistry and Biophysics, 2004, 31:198～203.
33.Zhen Meng, Jian-Zhong Shao*, Li-Xin Xiang, CpG oligodeoxynucleotides activate grass carp (Ctenopharyngodon idellus) macrophages. Developmental & Comparative Immunology, 2003, 27:313-321. (IF 2.909)
34.Li-Xin Xiang, Jian-Zhong Shao*, Role of intracellular Ca2+, reactive oxygen species, mitochondria transmembrane potential and antioxidant enzymes in heavy metal-induced apoptosis in fish cells, Bulletin of Environmental Contamination and Toxicology, 2003, 71:114-123.
35.Qing-Jun Zhou, Jian-Zhong Shao*, Li-Xin Xiang, Progress in fish antibacterial peptide research, Progress in Biochemistry and Biophysics, 2002, 29:682-685.
36.Li-Xin Xiang, Jian-Zhong Shao*, Apoptosis induction in fish cells under stress of six heavy metal ions, Progress in Biochemistry and Biophysics, 2001, 28:866-869.
37.Bing-Sen Xu, Jian-Zhong Shao*, Li-Xin Xiang, Advancement of several new typies of biochips. Progress in Biochemistry and Biophysics, 2001, 27:251-254.
