沙家豪博士，国家杰出青年基金承担者，江苏省生殖医学重点实验室主任，中华人民共和国第十一届全国人民代表大会代表，全国优秀教师。长期从事生殖医学研究，主要研究领域包括男性抗生育及配子发生的机理研究。学术团体任职：中国动物学会生殖生物学分会副理事长、中国解剖学会江苏分会副理事长、中华医学会生殖医学分会委员、中华医学会医学细胞生物学会理事、《生殖医学杂志》常务编委、《国外医学计划生育分册》常务编委、《中国男科杂志》编委、《男科学报》编委、《中国计划生育学杂志》编委。

主要研究方向：

男性抗生育

配子发生机理

目前主持承担的主要科研项目：

国家杰出青年基金：NYD-SPn基因功能的研究

国家自然科学基金重大研究计划：母源蛋白在早期胚胎组蛋白修饰中的作用

国家自然科学基金重点项目：人类睾丸蛋白质的表达及功能研究

国家重点基础研究规划973项目课题：睾丸中精子功能相关蛋白与疾病

国家重点基础研究规划973项目课题：精子功能的基础与临床研究

近年来发表的文章（IF≥3.0）：

1. Wang N, Zhang P, Guo X, Xie J, Huo R, Wang F, Chen L, Shen J, Zhou Z, Shi Q, Zhao B, Sha J*. Comparative proteome profile of immature rat ovary during primordial follicle assembly and development. Proteomics. 2009 Jul;9(13):3425-34.
2. Yu Y, Wu J, Fan Y, Lv Z, Guo X, Zhao C, Zhou R, Zhang Z, Wang F, Xiao M, Chen L, Zhu H, Chen W, Lin M, Liu J, Zhou Z, Wang L, Huo R* , Zhou Q*, Sha J. Evaluation of blastomere biopsy using mouse model indicates the potential high-risk of neurodegenerative disorders in the offspring. Mol Cell Proteomics. 2009 Mar 11. [Epub ahead of print].
3. Zhao C, Guo XJ, Shi ZH, Wang FQ, Huang XY, Huo R, Zhu H, Wang XR, Liu JY, Zhou ZM, Sha JH*. Role of translation by mitochondrial-type ribosomes during sperm capacitation: an analysis based on a proteomic approach. Proteomics. 2009 Mar;9(5):1385-99.
4. Guo X, Su B, Zhou Z, Sha J*. Rapid evolution of mammalian X-linked testis microRNAs. BMC Genomics. 2009 Mar 4;10:97.
5. Yin L, Chung CM, Huo R, Liu H, Zhou C, Xu W, Zhu H, Zhang J, Shi Q, Wong HY, Chen J, Lu Y, Bi Y, Zhao C, Du Y, Ma M, Cai Y, Chen WY, Fok KL, Tsang LL, Li K, Ni Y, Chung YW, Zhou Z, Sha J*, Chan HC*. A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction. Cell Mol Life Sci. 2009 Mar;66(5):900-8
6. Yin LL, Chung CM, Chen J, Fok KL, Ng CP, Jia RR, Ren X, Zhou J, Zhang T, Zhao XH, Lin M, Zhu H, Zhang XH, Tsang LL, Bi Y, Zhou Z, Mo F, Wong N, Chung YW, Sha J* , Chan HC*. A suppressor of multiple extracellular matrix-degrading proteases and cancer metastasis. J Cell Mol Med. 2008 Nov 6. [Epub ahead of print]
7. Ma M, Guo X, Wang F, Zhao C, Liu Z, Shi Z, Wang Y, Zhang P, Zhang K, Wang N, Lin M, Zhou Z, Liu J, Li Q, Wang L, Huo R, Sha J*, Zhou Q*. Protein Expression Profile of the Mouse Metaphase-II Oocyte. J Proteome Res. 2008 Sep 20. 7 (11): 4821–4830
8. Cui Y, Zhu H, Zhu Y, Guo X, Huo R, Wang X, Tong J, Qian L, Zhou Z, Jia Y, Lue YH, Hikim AS, Wang C, Swerdloff RS, Sha J*. Proteomic analysis of testis biopsies in men treated with injectable testosterone undecanoate alone or in combination with oral levonorgestrel as potential male contraceptive. J Proteome Res. 2008 Sep;7(9):3984-93. Epub 2008 Aug 15.
9. Huang XY, Guo XJ, Shen J, Wang YF, Chen L, Xie J, Wang NL, Wang FQ, Zhao C, Huo R, Lin M, Wang XR, Zhou ZM*, Sha JH. Construction of a Proteome Profile and Functional Analysis of the Proteins Involved in the Initiation of Mouse Spermatogenesis. J Proteome Res. 2008 Aug;7(8):3435-46. Epub 2008 Jun 27
10. Hu Y, Xing J, Chen L, Guo X, Du Y, Zhao C, Zhu Y, Lin M, Zhou Z, Sha J*. RGS22, A Novel Testis-Specific Regulator of G-protein Signaling Involved in Human and Mouse Spermiogenesis along with GNA12/13 Subunits. Biol Reprod. 2008:79:1021–1029
11. Zhang W, Qin C, Zhou ZM. Mesenchymal Stem Cells Modulate Immune Responses Combined With Cyclosporine in a Rat Renal Transplantation Model. Transplant Proc. 2007 Dec;39(10):3404-3408
12. Huo R, He Y, Zhao C, Guo XJ, Lin M, Sha JH. Identification of human spermatogenesis-related proteins by comparative proteomic analysis: a preliminary study. Fertil Steril. 2008 Oct;90(4):1109-18. Epub 2008 Feb 20
13. Zhang JJ, Wu JD, Huo R, Mao YZ, Lu Y, Guo XJ, Liu JY, Zhou ZM, Huang XY, Sha JH. ERp57 is a potential biomarker for human fertilization capability. Molecular Human Reproduction 2007; 13:(9):633–639
14. Zhao C, Huo R, Wang FQ, Lin M, Zhou ZM, Sha JH. Identification of several proteins involved in regulation of sperm motility by proteomic analysis. Fertil Steril. 2007 Feb;87(2):436-8. Epub 2006 Oct 30
15. Lu Y, Huo R, Yuan Y, Li J, Shi Q, Sha J. Human testicular protein NYD-SP16 is involved in sperm capacitation and the acrosome reaction. Fertil Steril. 2006 Oct;86 Suppl 4:1228-34. Epub 2006 Sep 11.
16. Zheng Y, Zhang J, Wang L, Zhou Z, Xu M, Li J, Sha JH. Cloning and characterization of a novel sperm tail protein, NYD-SP28. Int J Mol Med. 2006 Dec;18(6):1119-25
17. Zhu YF, Cui YG, Guo XJ, Wang L, Bi Y, Hu YQ, Zhao X, Liu Q, Huo R, Lin M, Zhou ZM, Sha JH. Proteomic analysis of effect of hyperthermia on spermatogenesis in adult male mice. J Proteome Res. 2006 Sep;5(9):2217-25
18. Du Y, Huang XY, Li JM, Hu YQ, Zhou ZM, Sha J. Human testis specific protein 1 expression in human spermatogenesis and involvement in the pathogenesis of male infertility. Fertil Steril 2006;85(6):1852-1854
19. Hu YQ, Lu Y, Zhou ZM, Du Y, Xing J, Wang L, Lin M, Sha JH. Defective expression of Galpha12 in the testes of azoospermia patients and in the spermatozoa with low motility. J Mol Med. 2006 May;84(5):416-424
20. Huang M, Wang H, Li JM, Zhou Z, Du Y, Lin M, Sha J. Involvement of ALF in human spermatogenesis and male infertility. Int J Mol Med. 2006 Apr;17(4):599-604
21. Wang L, Zhu YF, Guo XJ, Huo R, Ma X, Lin M, Zhou ZM, Sha JH. A two-dimensional electrophoresis reference map of human ovary. J Mol Med 2005;83:812-821
22. Wang H, Zhou ZM, Lu L, Xu ZY, Sha JH. Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis. Int J Mol Med. 2005;15(6):949-953
23. Zheng Y, Yuan W, Zhou ZM, Xu M, Sha JH. Molecular cloning and expression of a novel alternative splice variant of BRDT gene. Int J MolMed 2005;15(2):315-321
24. Huang XY, Li JM, Lu L, Xu M, Xiao JH, Yin LL, Zhu H, Zhou ZM, Sha JH. Novel development-related alternative splices in human testis identified by cDNA microarrays. Journal of Andrology, 2005;26(2):189-196
25. Huang XY, Zhang J, Lu L, Yin LL, Xu M, Wang YQ, Zhou ZM, Sha JH. Cloning and expression of a novel CREB mRNA splice variant in human testis. Reproduction 2004;128:775–782
26. Hu YQ, Zhou ZM, Huang XY, Xu M, Lu L, Xu ZY, Li JM, Sha JH. Expression of a novel DnaJA1 alternative splicing in human testis and sperm. International Journal of Andrology 2004;27:343-349
27. Huang XY, Wang H, Xu M, Lu L, Xu ZY, Li JM, Zhou ZM, Sha JH. Expression of a novel RAD23B mRNA splice variant in human testis. Journal of Andrology 2004; 25(3):363-368
28. Wang H, Xu M, Li JM, Xiao JH, Xu ZY, Zhou ZM, Sha JH. A Spermatogenesis-related gene expression profile in Human Spermatozoa and Its Potential Clinical Application. Journal of Molecular Medicine 2004; 82:317-324
29. Zhu H, Zhu JX, Lo PS, Li J, Leung KM, Rowlands DK, Tsang LL, Yu MK, Jiang JL, Lam SY, Chung YW, Zhou ZM, Sha JH, Chang Chan H. Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C. Lancet 2003;362:2059-2065
30. Xu M, Xiao JH, Chen J, Li JM, Yin LL, Zhu H, Zhou ZM, Sha JH. Identification and characterization of a novel human testis-specific Golgi protein, NYD-SP12. Molecular Human Reproduction 2003;9(1):9-17
31. Cheng LJ, Li JM, Chen J, Ge YH, Yu ZR, Han DS, Zhou ZM, Sha JH. NYD-SP16, a novel gene associated with spermatogenesis of human testis. Biology of Reproduction. 2003;68(1):190-198
32. Cheng LJ, Zhou ZM, Li JM, Zhu H, Zhu H, Zhou YD, Wang LR, Lin M, Sha JH. Expression of a novel HsMCAK mRNA splice variant,tsMCAK gene in human testis. Life Science 2002;71(23):2741-2757
33. Sha JH, Zhou ZM, Li JM, Yin LL, Yang HM, Hu GX, Luo M, Chan HC, Zhou KY. Identification of development/spermatogenesis-related genes in human and mouse testes using cDNA arrays. Molecular Human Reproduction 2002; 8(6):511-517
34. Xiao JH, Xu M, Li JM, Chan HC, Lin M, Zhu H, Zhang W, Zhou ZM, Zhao BG, Sha JH, et al. NYD-SP6, a novel gene potentially involved in regulating testicular development/spermatogenesis. Biochem Biophys Res Commun. 2002; 291(1): 101-10.
35. Zhou ZM, Sha JH, Li JM, Lin M, Zhu H, Zhou YD, Wang LR, Zhu H, Wang YQ, Zhou KY. Expression of a novel reticulon-like gene in human testis. Reproduction 2002,123:227