臧敬五 医学博士 免疫学博士
分子免疫学研究组 研究组长
jwzang@sibs.ac.cn
Education and Major Academic Appointments
Medical Degree (1984) Shanghai Second Medical University
Graduate study (1986) Shanghai Institute of Immunology, SSMU
Ph.D. in Immunology (1990) University of Brussels, Belgium
Postdoctoral fellow (1992) Harvard Medical School, USA
Head, Immunology Unit (1994) Dr. Willems Biomedical Research Institute, University of Limberg, Belgium
Associate Professor (1996) Baylor College of Medicine, USA
Research Director (1996) Baylor Multiple Sclerosis Center, USA
Clinical Residency (1998) Baylor College of Medicine, USA
Professor (2001) Neurology/Immunology, Baylor College of Medicine, US
Director (2002) Institute of Health Sciences, SIBS/SSMU, China
Clinical and Laboratory Certifications
USMLE Certification (1996) Education Commission for Foreign Medical Graduates, USA
CLIA Laboratory Certification (2002) Department of Health and Human Resources, USA
US Medical Licensure (2005) Texas Medical Board, USA
China Medical Licensure (2005) Ministry of Health, China
Clinical Trial Investigator (2005) Certification by ACRP, USA
主要成果
臧敬五教授的研究是立足于从临床问题中提炼出关键免疫学科学问题，用最新的科学手段在分子和细胞水平上进行研究，并致力于成果的临床应用。
一、通过对髓鞘抗原自身反应T细胞的研究，揭示了其在体内激活的可能机理及在多发性硬化炎症和中枢神经系统脱髓鞘病理过程中的关键作用。
二、首创用灭活髓鞘抗原反应T细胞治疗多发性硬化（T细胞疫苗）。初步阐明了其体内免疫调节机理，并正在探索T细胞疫苗在多发性硬化和类风湿关节炎免疫治疗中的临床应用前景，研制T细胞受体多肽治疗性疫苗。
Our most recent research interest is briefly described as follows
Role of regulatory T cells in autoimmune conditions. Our research interest focuses on the basic mechanisms involved in the induction and conversion of CD4+CD25+ Treg by Copolymer-I (PNAS, 102: 6449-6454, 2005), gamma-interferon (JCI, In press, 2006) and T cell vaccination (PNAS, 103: 5024-5029, 2006). Using a humanized mouse model, our research expands to the role of thymus in the development and differentiation of CD4+CD25+ regulatory T cells. The other aspect of our research in this area is related to elucidation of signaling events involved and cytokines required for the function of CD4+CD25+ regulatory T cells in humans and rodents.
Role of autoreactive T cells in multiple sclerosis and rheumatoid arthritis and the development of novel treatment strategies to target at autoreactive T cells. Recently completed studies include: T cell receptor V gene analysis (Genes and Immunity, 6: 248-261, 2005), role of osteopontin as a key pro-inflammatory cytokine (JCI, 115: 1060-1067, 2005), involvement of MAPKK pathways (Journal of Immunology, 173: 7299-7307, 2004), functional properties of CD8+ autoreactive T cells (Journal of Immunology, 172: 5120-127, 2004) and stem cells (Brain, 127: 996-1008, 2004). Several lines of research are on-going to develop novel treatment strategies for MS and RA, which include T cell vaccination (Arthritis & Rheumatism and PNAS, 2006) and the use of neural stem cells or anti-inflammatory small molecules from Chinese herbal medicine.
全部论文、著作
全部论文
Jingwu Zhang. Yin and Yang interplay of IFN-gamma in inflammation and autoimmune disease. Journal of Clinical Investigation 2007, in press
Guangjie Chen, Ningli Li, Ying C. Q. Zang, Dongqing Zhang, Dongyi He, Guozhang Feng, Liqing Ni, Rong Xu, Li Wang, Baihua Shen, Jingwu Zhang. Vaccination With Selected Synovial T Cells in Rheumatoid Arthritis. Arthritis and Rheumatism 56(2), 453–463, 2007.
* This paper is accompanied with an Editorial published in the same issue:
Brent Prakken and Salvatoire Albani. Exploiting T cell crosstalk as a vaccination strategy for rheumatoid arthritis. Arthritis and Rheumatism 56, 389-392, 2007
Zhong L. Ju, Gui Y. Shi, Jin X. Zuo, Jingwu Zhang, Jian Sun. Unexpected development of autoimmunity in BAFF-R-mutant MRL-lpr mice. Immunology 120(2):281-9, 2007.
Jun-hao Hu, Ting Chen, Zi-heng Zhuang, Ling Kong, Ming-Can Yu, Yusen Liu, Jingwu Zhang, Bao-Xue Ge. Feedback control of MKP-1 expression by p38. Cellular Signalling 19(2):393-400, 2007.
Hong Zhou, Zhijun Jiao, Jijun Pana, Jian Hong, Jiaxian Tao, Ningli Li, Yun Zhou, Jingwu Zhang, Kuang-Yen Chou. Immune suppression via IL-4/IL-10-secreting T cells: A nontoxic property of anti-HIV agent Trichosanthin. Clinical Immunology 122(3):312-22, 2007.
Zhaojun Wang, Jian Hong, Wei Sun, Guangwu Xu, Ningli Li, Xi Chen, Ailian Liu, Lingyun Xu, Bing Sun, Jingwu Zhang. Role of g-Interferon in Induction of Foxp3 and Conversion of CD4+CD25- T cells to CD4+ Regulatory T Cells. Journal of Clinical Investigation 116(9):2434-2441, 2006.
Bing Wan, Hong Nie, Ailian Liu, Guozhang Feng, Dongyi He, Rong Xu, Qi Zhang, Chen Dong, Jingwu Zhang. Aberrant Regulation of Synovial T Cell Activation by Soluble Co-Stimulatory Molecules in Rheumatoid Arthritis. Journal of Immunology 177(12):8844-8850, 2006.
Guilin Yang, Ailian Liu, Qing Xie, Taylor B. Guo, Bing Wan, Boping Zhou, Jingwu Zhang. Association of CD4+CD25+Foxp3+ Regulatory T Cells with Chronic Activity and Viral Clearance in Patients with Hepatitis B. International Immunology. 19(2):133-40, 2007
Wei Sun , Ying C. Q. Zang, Xin Liu, Jingwu Zhang. Altered Expression of Vasoactive Intestinal Peptide Receptors in T Lymphocytes and Aberrant Th1 Immunity in Multiple Sclerosis. International Immunology 18(12):1691-1700, 2006.
Jian Hong, Ying Zang, Hong Nie and Jingwu Zhang. CD4+ Regulatory T Cell responses induced by T cell vaccination in patients with multiple sclerosis. Proceedings of National Acadiy of Science USA 103:5024-5029, 2006
Yun Ding, Mika Li, Jinwu Zhang, Ningli Li, Zongqin Xia, Yaer Hu, Sunxin Wang, Guo-Huang Fan. The 73-kDa Heat Shock Cognate Protein is a CXCR4 Binding Protein that Regulates the Receptor Endocytosis and the Receptor-Mediated Chemotaxis. Molecular Pharmacology 69(4):1269-79, 2006.
Zi-Heng Zhuang, Lei Sun, Ling Kong, Jun-Hao Hu, Ming-Can Yu, Peter Reinach, Jingwu Zhang, Bao-Xue Ge. Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB. Cellular Signalling 18(7):964-70, 2006.
Xiaodong Wu, Wanqiu Hou, Shuhui Sun, Enguang Bi, Yuan Wang, Mude Shi, Jingwu Zhang, Chen Dong and Bing Sun. Novel function of IFN-g , negative regulation on Dendritic Cell migration and T cell priming. Journal of Immunology 15;177(2):934-943, 2006.
Li Wang, Fang Du, Qi Cao, Huiming Sheng, Baihua Shen, Yan Zhang, Yingna Diao, Jingwu Zhang, Ningli Li. Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45b. Cell Research 16(8):702-712, 2006.
Lingqiao Zhu, Fang Ji, Yuan Wang, Yi Zhang, Qiang Liu, Jingwu Zhang, Kouji Matsushima, Qi Cao, Yanyun Zhang. Synovial Autoreactive T Cells in Rheumatoid Arthritis Resist IDO-Mediated Inhibition. Journal of Immunology 177: 8226-8233, 2006.
Cherry Luo, Heng Pan, Marjelo Mines, Kurt Watson, Jingwu Zhang, Guo-Huang Fan. CXCL12 induces tyrosine phosphorylation of cortactin which plays a role in CXCR4-mediated extracellular signal regulated kinase activation and chemotaxis. Journal of Biological Chemistry 281(40):30081-93, 2006.
Jiawei Lu, Zhenyu Lu, Jingwu Zhang, Wei Dai, Luo Lu, Ming Xu. TGF-?2 inhibits AKT activation and FGF-2-induced corneal endothelial cell proliferation. Experimental Cell Research 312(18):3631-3640, 2006.
Guangwu Xu, Hong Nie, Ningli Li, Wenxin Zheng, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, Jian Hong, Jingwu Zhang. Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. Journal of Clinical Investigation 115(4):1060-1067, 2005
Jian Hong, Ningli Li, Xuejun Zhang, Biao Zheng, Jingwu Zhang. Induction of Expression of Transcription Factor FoxP3 and Function of CD4+CD25+ Regulatory T Cells. Proceedings of National Acadiy of Science USA 102(18):6449-6454, 2005
Guangwu Xu, Wei Sun, Dongyi He, Li Wang, Wenxin Zheng, Hong Nie, Liqing Ni, Dongqing Zhang, Ningli Li, Jingwu Zhang. Overexpression of osteopontin in rheumatoid synovial mononuclear cells is associated with joint inflammation, not with genetic polymorphism. Journal of Rheumatology 32:410-416, 2005
Wei Sun, Hong Nie, Ningli Li, Ying Zang, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, Sarvamangala Prasad, Rachel R Robinson, Walter Ho, Eli Sercarz, Jingwu Zhang. Skewed T-cell receptor BV14 and BV16 expression and shared CDR3 sequence and common sequence motifs in synovial T cells of rheumatoid arthritis. Genes and Immunity 6:248-261, 2005
Zhong-Ping Lu, Zhong-Liang Ju, Guang-Yin Shi, Jingwu Zhang, Jian Sun. Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription. Biochiical and Biophysical Research Communications 330 (1):204-209, 2005
Qingwei Luo, Yun Ding, Kurt Watson, Jingwu Zhang, Guo-Huang Fan. N-Methyl-D-aspartate Attenuates CXCR2-Mediated Neuroprotection through Enhancing the Receptor Phosphorylation and Blocking the Receptor Recycling. Molecular Pharmacology 68:528-537, 2005.
Jian Qiu, Xiao-hui Wei, Fang Geng, Rui Liu, Jingwu Zhang, Yu-hong Xu. Multivesicular liposome formulations for the sustained delivery of interferon α-2b. Acta Pharmacologica Sinica 26(11):1395-1401, 2005.
Ying C.Q. Zang, Sheri M. Skinner, Rachel R. Robinson, Sufang Li, Victor M. Rivera, George J. Hutton, Jingwu Zhang. Regulation of differentiation and functional properties of monocytes and monocyte-derived dendritic cells by interferon beta in multiple sclerosis. Multiple Sclerosis 10(5):499-506(8), 2004
Jian Hong, Ying Zang, George Hutton, Victor M. Rivera, Jingwu Zhang. Gene expression profiling of relevant biomarkers for treatment evaluation in multiple sclerosis. Journal of Neuroimmunology 152:126-139, 2004
Wei Sun, Uday Popat, George Hutton, Ying CQ Zang, Geoffrey Land, Robert Krance, George Carrum, Geoffrey A. Land, Helen Heslop, Malcolm Brenner, Jingwu Zhang. Characteristics of T Cell Receptor Repertoire and Myelin-Reactive T Cells Reconstituted from Autologous Hiatopoietic Sti Cell Grafts in Multiple Sclerosis. Brain 127(5):996-1008, 2004.
Rana AK Singh and Jingwu Zhang. Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand. Journal of Immunology 173(12):7299-307, 2004
Ying C. Q. Zang, Sufang Li, Victor M. Rivera, Jian Hong, Rachel R. Robinson, Wini T. Breitbach, James Killian, Jingwu Zhang. Increased CD8+ Cytotoxic T Cell Responses to Myelin Basic Protein in Multiple Sclerosis. Journal of Immunology 172:5120-5127, 2004.
Jian Hong, Ying C.Q. Zang, Sufang Li, Victor Rivera, Jingwu Zhang. Ex vivo detection of myelin basic protein-reactive T cells in multiple sclerosis and controls using specific TCR oligonucleotide probes. European Journal of Immunology 34:870-881, 2004.
Qishui Ou, Lin Lin, Lidong Huang, Fuxiang Chen, Kegui Wu, Peihua Lu, Jingwu Zhang, Kuang-Yen Chou. Persistence of MHC DR Nonexpression on Swine Cells by Introduction of a Mutated MHC Class II Transactivator Gene: A Comparison with the Effect Induced by Antisense RNA. Journal of Clinical Immunology 24(1):97-106, 2004.
Yingping Cao, Hong Zhou, Zexian Zheng, Ningli Li, Bo-hua Shen, Tsi-Siang Shih, Hong Jian, Jingwu Zhang, Kuang-Yen Chou. Keratinocytes induce local tolerance to skin graft by activating interleukin-10-secreting T cells in the context of costimulation molecule B7-H1. Transplantation 75:1390-1396, 2003.
Hassan Salama, Ying Zang, Azza El-Mongui, Jingwu Zhang. Blocking effects of serum reactive antibodies induced by glatiramer acetate treatment in multiple sclerosis. Brain 126:2638-2647, 2003
Ying Zang, Jian Hong, Rachel Robinson, Victor M. Rivera, Jingwu Zhang. Immune regulatory properties and interactions of Copolymer-I and beta-interferon 1a in multiple sclerosis. Journal of Neuroimmunology 137:144-53, 2003
Hassan H Salama, Oldrich J Kolar, Ying C.Q. Zang and Jingwu Zhang. Effects of Combination Therapy of Beta-Interferon 1a and Prednisone on Serum Immunologic Markers in Patients with MS. Multiple Sclerosis 9:28-31, 2003
Maria Tejada-Simon, Ying Zang, Jian Hong, Victor Rivera, and Jingwu Zhang. Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis.Annals of Neurology 53:189-197, 2003.
Ying C. Q. Zang, Jian Hong, Victor M. Rivera, James Killian, Jingwu Zhang. Human Anti-Idiotypic T Cells Induced by TCR Peptides Corresponding to a Common CDR3 Sequence Motif in Myelin Basic Protein-Reactive T Cells. International Immunology 15:1073-1080, 2003
Maria Tejada-Simon, Jian Hong, Victor Rivera, and Jingwu Zhang. Skewed autoantibody reactivity to the extracellular domain of myelin oligodendrocyte glycoprotein in multiple sclerosis. Immunology 107:403-410, 2002
Maria Tejada-Simon, Jian Hong, Victor Rivera, James Killian, Ying Zang, Jingwu Zhang. Detection of viral DNA and immune responses to the human herpesvirus 6 101-kilodalton virion protein in patients with multiple sclerosis and in controls. Journal of Virology 76:6147-6154, 2002
Ying Zang, Jyotsnabaran Halder, Jian Hong, Victor M. Rivera, Jingwu Zhang. Regulatory effects of estriol on T cell migration and cytokine profile: inhibition of transcription factor NF-kappa B. Journal of Neuroimmunology 124:106-114, 2002
Jian Hong, Maria V. Tejada-Simon, Victor M. Rivera, Ying C.Q. Zang, Jingwu Zhang. Anti-Viral Properties of Interferon Beta Treatment in Patients with Multiple Sclerosis. Multiple Sclerosis 8:237-242, 2002
Jingwu Zhang, Victor M. Rivera, Maria V. Tejada-Simon, Deye Yang, Jian Hong, Sufanfg Li, Hani Haykal, James Killian, Ying C.Q. Zang. T Cell Vaccination in Multiple Sclerosis: Results of a Preliminary Study. Journal of Neurology 249:212-218, 2002
Schroers R, Huang XF, Hammer J, Jingwu Zhang, Chen SY. Identification of HLA DR7-restricted epitopes from human telomerase reverse transcriptase recognized by CD4+ T-helper cells. Cancer Research 62:2600-2605, 2002.
Godkin AJ, Smith KJ, Willis A, Tejada-Simon MV, Jingwu Zhang, Elliott T, Hill AV.J Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions. Journal of Immunology 166:6720-6727, 2001
Maria Tejada-Simon, Jian Hong, Victor Rivera, Jingwu Zhang. Reactivity pattern and cytokine profile of T cells primed by myelin peptides in multiple sclerosis and healthy individuals. European Journal of Immunology 3:907-917, 2001
Ying Zang, Jyotsnabaran B. Halder, Ajoy K. Samanta, Jian Hong, Victor Rivera, Jingwu Zhang. Regulation of chiokine receptor CCR5 and production of RANTES and MIP-1a by interferon-beta. Journal of Neuroimmunology 112:174-180, 2001.
Jian Hong, Ying Zang, Victor M. Rivera, Jingwu Zhang. Reactivity and regulatory properties of human anti-idiotypic antibodies induced by T cell vaccination. Journal of Immunology 165:6858-6864, 2000
Ying Zang, Ajoy K. Samanta, Jyotsnabaran B. Halder, Jian Hong, Victor Rivera, Jingwu Zhang. Aberrant T cell migration toward RANTES and MIP-1 alpha in patients with multiple sclerosis - Overexpression of chiokine receptor CCR5. Brain 123:1874-1882, 2000
Ying Zang, Deye Yang, Jian Hong, Maria Tejada-Simon, Victor Rivera and Jingwu Zhang. Immunoregulation and blocking antibodies induced by interferon beta treatment in MS. Neurology 55:397-404, 2000
Maria V. Tejada-Simon, Deye Yang, Ying Zang, Victor Rivera and Jingwu Zhang. Aberrant T cell responses to myelin antigens during clinical exacerbation in patients with multiple sclerosis. International Immunology 12:1641-1650, 2000
Ying Zang, Jian Hong, Sufang Li, James M. Killian, Victor M. Rivera, Jingwu Zhang. Preferential recognition of TCR hypervariable regions by human anti-idiotypic T cells induced by T cell vaccination. Journal of Immunology 164:4011-4017, 2000
Ying Zang, Milena Kozovska, Sufang Li, Savita Mann, James Killian, Victor Rivera,Jingwu Zhang. Th2 immune regulation induced by T cell vaccination in patients with multiple sclerosis. European Journal of Immunology 30:908-913, 2000
RA Hurley, K Taber, Jingwu Zhang and L Hayman. Neuropsychiatric presentation of multiple sclerosis. Journal of Neuropsychiatry Clin. Neurosci. 11:5-7, 1999
Rana Singh, Ying, Zang, Sufang Li and Jingwu Zhang. Th1 and Th2 deviation induced by altered peptide ligand: Regulation of Lck, Fyn and Zap-70. Journal of Immunology 163:6393-6402, 1999
Michael Pazara, ianuela Gussoni, Ann Begovich, Ying Zang, Stanley Appel, Larry Steinman, Jingwu Zhang. T cell receptor V gene rearrangients in the spinal cords and cerebrospinal fluid of patients with amyotrophic laterial sclerosis. Journal of Neurobiology 5:392-405, 1999
Jian Hong, Ying C. Q. Zang, Sufang Li, James M. Killian, Victor M. Rivera, Jingwu Zhang. A Common TCR Sequence Motif Shared by Myelin Basic Protein-Reactive T Cells in Patients with Multiple Sclerosis. Journal of Immunology 163:3530-3538, 1999.
Milena E. Kozovska, Jian Hong, Ying C. Q. Zang, Victor Rivera, James Killian, Jingwu Zhang. Cytokine Regulation of Myelin Basic Protein-Reactive T Cells by Beta-interferon in Patients with Multiple Sclerosis. Neurology 53:1692-1697, 1999
Kisco Kil, Ying C. Q. Zang, Deye Yang, Jian Hong, Sufang Li, James M. Killian, Victor M. Rivera, Jingwu Zhang. Increased Frequency of Myelin Basic Protein-Reactive T Cells in Patients with Spinal Cord Injury. Journal of Neuroimmunology 98:201-207, 1999
Ying C. Q. Zang, Milena Kozovska, Jian Hong, Savita Mann, Sufang Li, James M. Killian, Victor M. Rivera, Jingwu Zhang. Increased Frequency of Fas-Sensitive Myelin Basic Protein-Reactive T Cells in Patients with Multiple Sclerosis. European Journal of Immunology 29:1692-1700, 1999
Caroline Vandevyver, Kris Motmans, Piet Stinissen, Jingwu Zhang, Jef Raus. Cytokine Mrna profile of myelin basic protein reactive T-cell clones in patients with multiple sclerosis. Autoimmunity 28:77-89, 1998.
Piet Stinissen, Jingwu Zhang, Caroline Vandervyver, Guy Hermans and Jef Raus. T cell response induced by T cell vaccination in multiple sclerosis patients: Reactivity and T cell receptor V gene usage. Journal of Neuroimmunology 87:94-104, 1998
Ying Zang, Milena Kozovska, Iwan Aebischer, Victor Rivera, Wei Luo, Paul Crowe, Stefan Boehme, Jingwu Zhang. Limited heterogeneity in TCR V alpha gene rearrangients of DR2-restricted T cells recognizing an immunodominant peptide of MBP in multiple sclerosis. International Immunology 10:991-998, 1998.
Milena Kozovska, Ying Zang, Iwan Aebischer, Victor Rivera, Wei Luo, Paul Crowe, Stefan Boehme, Jingwu Zhang. T cell responses to an immunodominant epitope of myelin basic protein in patients with multiple sclerosis: structrual requirients and clinical implication. European Journal of Immunology 28:1894-1901, 1998.
Linda Celis, Caroline Vandevyver, Piet Geusens, Jan Dequeker, Jef Raus and Jingwu Zhang. Clonal expansion of mycobacterial heat-shock protein-reactive T lymphocytes in the synovial fluid and blood of rheumatoid arthritis patients. Arthritis and Rheumatism 40:510-519, 1997.
Guy Hermans, Nadia Mertens, Lysiane Hauben, Piet Stinissen, Jef Raus and Jingwu Zhang. The cytokine profile of MBP-reactive T cells and early lines in multiple sclerosis and healthy controls. Annals of Neurology 42:18-27, 1997.
Robert Medaer, Piet Stinissen, Luc Truyen and Jef Raus and Jingwu Zhang. Depletion of myelin basic protein-reactive T cells by T cell vaccination: A pilot clinical trial in multiple sclerosis. The Lancet 346:807-808, 1995.
Silva Markovic-Plese, Hikoaki Fukaura, Jingwu Zhang, Ahmad Al-Sabbagh, Scott Southwood, Alessandro Sette, Vijay Kuchroo, David Hafler. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. Journal of Immunology 155:982-992, 1995.
Jingwu Zhang, Caroline Vandevyver, Piet Stinissen, Robert Medaer and Jef Raus. In vivo clonotypic regulation of human myelin basic protein-reactive T cells induced by T cell vaccination. Journal of Immunology 155:5868-5877, 1995.
Piet Stinissen, Caroline Vandevyver, Jef Raus and Jingwu Zhang. Superantigen reactivity of T cell clones isolated from patients with multiple sclerosis. Cellular Immunology 166:227-235, 1995.
Piet Stinissen, Caroline Vandevyver, Els Smeyers, Luc Vandegaer Jan Nies, Luc Tuyls, Robert Medaer, Jef Raus and Jingwu Zhang. Increased frequency of T cells in multiple sclerosis: functional propeties and T cell receptor V gene usage. Journal of Immunology 154:4883-4894, 1995.
Jingwu Zhang and Jef Raus. Clonal depeletion of human myelin basic protein-reactive T cells by T cell vaccination. Annals of the New York Acadiy of Sciences 756:323-326, 1995.
Caroline Vandevyver, Nadja Mertens, Peter Van den Elsen, Jef Raus and Jingwu Zhang. Clonal expansion of myelin basic protein-reactive T cells in multiple sclerosis: restricted T cell receptor V gene usage and CDR sequence. European Journal of Immunology 25:958-968, 1995.
Jingwu Zhang, Caroline Vandevyver, Piet Stinissen, Ella van den Berg-Loonen and Jef Raus. Activation and clonal expansion of human myelin basic protein-reactive T cells by bacterial superantigens. Journal of Autoimmunity 8:1-18, 1995.
Ying Chin, J. Janssens, J. Bleus, Caroline Vandevyver, Jingwu Zhang and J. Raus. T cell receptor V usage of tumor infiltration lymphocyte lines cloned from human breast tumor and melanoma. International Journal of Oncology 7:147-153, 1995.
Ying Chin, J. Janssens, J. Bleus, Jingwu Zhang and J. Raus. Cellular and molecular analysis of tumor infiltrating lymphocytes from human breast cancer at clonal level. Oncology Reports 1:577-583, 1994.
Hans Deckmyn, Jingwu Zhang, E. Van Houtte and J. Vermylen. Production and molecular sequence of an inhibitory human IgM autoantibody directed against platelet glycoprotein Ia/Iia. Blood 84:1968-1974, 1994.
Kai Wucherpfennig, Jingwu Zhang, Chris Witek, Makoto Matsui, Yalda Modabber, Kohei Ota and David Hafler. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. Journal of Immunology 152:5581-5592, 1994.
Jingwu Zhang, Silva Markovic, Blishda Lacet, Jef Raus, Howard Weiner and David Hafler. Increased frequency of IL-2 responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with MS. Journal of Experimental Medicine 179:973-984, 1994.
David Hafler, Jingwu Zhang, J. LaSalle, C. Donnelly, Howard Weiner and Kai Wucherpfennig. The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis. Clinical Experimental Rheumatology 11:39-40, 1993.
Jingwu Zhang, Robert Medaer, Piet Stinissen, David Hafler, Jef Raus. MHC restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science 261:1451-1454, 1993.
Henry Oettinger, Ahmad Al-Sabbagh, Jingwu Zhang, Jannie LaSalle, Howard Weiner and David Hafler. Biological activity of recombinant human myelin basic protein. Journal of Neuroimmunology 44:157-162, 1993.
Ying Chin, J. Janssens, E. Smeyers, J. Bleus, Jingwu Zhang and J. Raus. Large scale expansion of human tumor infiltrating lymphocytes with surface-modified stimulator cells for adoptive immunotherapy. Anticancer Research 12:733-736, 1992.
Jingwu Zhang, Robert Medaer, George Hashim, Chin Ying, Ella van den Berg-Loonen and Jef Raus. Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: precursor frequency, fine specificity, and cytotoxicity. Annals of Neurology 32:330-338, 1992.
Jingwu Zhang, Marleen Schreurs, Robert Medaer and Jef Raus. Regulation of myelin basic protein-specific helper T cells in multiple sclerosis: generation of suppressor T cell lines. Cellular Immunology 139:118-130, 1992.
Avraham Ben-Nun, Roland Liblau, Lydia Cohen, Dan Lehmann, Elisabeth Tournier-Lasserve, Anthony Rosenzweig, Jingwu Zhang, Jef Raus and Marie-Anne Bach. Restricted T cell receptor Vbeta gene usage by myelin basic protein-specific T cell clones in multiple sclerosis: predominant genes vary in individuals. Proceedings of National Acadiy of Science 88:2466-2470, 1991.
Jingwu Zhang, Chin Ying, Paula Henderikx, Robert Medaer, Chi-Hsin Chou and Jef Raus. Antibodies to myelin basic protein and measles virus in multiple sclerosis: precursor frequency analysis of the antibody producing B cells. Autoimmunity 11:27-34, 1991.
Jingwu Zhang, Chi-Hsin Chou, George Hashim, Robert Medaer and Jef Raus. Preferential peptide specificity and HLA restriction of myelin basic protein-specific T cell clones derived from MS patients. Cellular Immunology 129:189-198, 1990.
Jingwu Zhang, Paula Henderikx, Chin Ying Robert Medaer and Jef Raus A method to establish antibody secreting B cell lines and simultaneously perform frequency analysis. Journal of Immunological Methods 123:153-154, 1989.
Jingwu Zhang, Jos Lambrechts, Harri Heyligen, Arthur Vandenbark and Jef Raus. Human B cell lines secreting IgM antibody specific for myelin basic protein. Journal of Neuroimmunology 23:249-256, 1989.
Jingwu Zhang, Arthur Vandenbark, Marie-Paule Jacobs, Halina Offner and Jef Raus. Murine monoclonal anti-myelin basic protein antibodies inhibit proliferation and cytotoxicity of MBP-specific human T cell clones. Journal of Neuroimmunology 24:87-94, 1989.
Jingwu Zhang, Wim Weber, Jannie Borst, Arthur Vandenbark and Jef Raus. A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule. Journal of Immunology 142:3917-3922, 1989.
Wim Weber, Jingwu Zhang and Wim Buurman, Human myelin basic protein-specific cytotoxic T lymphocyte clones are HLA class II restricted. Transplantation Proceedings 20:232-234, 1988.
全部专著与综述
Jingwu Zhang, Howard Weiner and David Hafler
Autoreactive T cells in multiple sclerosis (review)
International Review of Immunology 9:183-201, 1992.
Jingwu Zhang and Jef Raus
T cell vaccination in autoimmune diseases: from laboratory to clinic (editorial)
Human Immunology 38:87-96, 1993.
Jingwu Zhang and Jef Raus
T cell vaccination in multiple sclerosis: hopes and facts.
Acta Neurologica Belgica 94:112-115, 1994.
Jingwu Zhang and Jef Raus
Myelin basic protein-reactive T cells in multiple sclerosis: pathologic relevance and therapeutic targeting
Cytotechnology 16:181-187, 1994.
Jingwu Zhang and Jef Raus
T cell vaccination trial in multiple sclerosis
in Autoimmune disease and T cell vaccination, Jingwu Zhang and Jef Raus Eds.
pp. 135-160, 1995. Springer-Verlag, Landes Medical Publishers, Austin, USA.
Jingwu Zhang
Autoreactive T cells and their pathological relevance in human autoimmune diseases.
in Autoimmune disease and T cell vaccination, Jingwu Zhang and Jef Raus Eds.
pp. 83-118, 1995. Springer-Verlag, Landes Medical Publishers, Austin, USA.
Jingwu Zhang
Multiple sclerosis: perspectives on autoimmune pathology and prospects for therapy
In Current Neurology 15:115-155, 1995. Ed. S. Appel. Mosby-Year Book, Chicago, USA.
Piet Stinissen, Jingwu Zhang, Caroline Vandevyver and Jef Raus
Autoreactive T lymphocytes in multiple sclerosis.
in Neurochiistry, Teelken and Korf. eds. pp. 113-119, 1997. Plenum, New York.
Piet Stinissen, Jef Raus and Jingwu Zhang
Autoimmune pathogenesis of multiple sclerosis: Role of autoreactive T lymphocytes and new immunotherapeutic strategies
Critical Review of Immunology 17:33-75, 1997
Jingwu Zhang, Piet Stinissen, Robert Medaer and Jef Raus
T cell vaccination: clinical application in autoimmune diseases
Journal of Molecular Medicine 74:653-662, 1996
Jingwu Zhang and Jef Raus
T cell vaccination in multiple sclerosis (review)
Multiple Sclerosis 1:353-356, 1996.
Piet Stinissen, Jingwu Zhang, Robert Medaer, Caroline Vandervyver and Jef Raus
Vaccination with autoreactive T cell clones in multiple sclerosis: Overview of immunological and clinical data
Journal of Neuroscience Research 45:500-511, 1996
Jingwu Zhang, Victor Rivera, Jef Raus and Lawrence Steinman
New treatments for multiple sclerosis.
in Current Neurology. S. Appel (ed)., IOS Press-Ohmsha, Amsterdam, 17:157-184, 1997.
Piet Stinissen, Jingwu Zhang, Caroline Vandervyver and Jef Raus
Autoreactive T lymphocytes in multiple sclerosis: Pathologic role and therapeutic targeting.
in Implications for therapy of MS, Neurochiistry and Neuroimmunology of EAE, pp 113-119
eds. Teelken and Korf, Plenum Press, New York, 1997
Jingwu Zhang, David Hafler, Reinhard Holfeld, Ariel Miller (book)
Immunotherapy in Neuroimmunologic Diseases. Martin Dunitz Publishers, London, 1998
Jingwu Zhang, Piet Stinissen, Robert Medaer, Luc Truyen and Jef Raus
T cell vaccination for the treatment of multiple sclerosis.
In Immunotherapy in Neuroimmunologic Diseases. Jingwu Zhang, et al. (eds.), Martin Dunitz Publishers, London, pp 215-232, 1998
Jingwu Zhang
ierging therapeutic targets in multiple sclerosis: Suppression and elimination of myelin-autoreactive T lymphocytes.
In: ierging therapeutic targets, Ashley Medical Publishers, London, 2:1-20, 1998
Paul Conlon, Jorge Oksenberg, Jingwu Zhang and Lawrence Steinman
The Immunobiology of Multiple Sclerosis: An Autoimmune Disease of the Central Nervous Systi.
Neurobiology of Disease 6:149-166, 1999
Gholam Motamedi and Jingwu Zhang
Diyelinating and inflammatory diseases.
Neurology Pearls of Wisdom In M. Labanowski, Ed., Boston Medical Publishing Corp., Boston, pp. 63-76, 1999.
Ariel Miller and Jingwu Zhang
T cell vaccination and antigen-driven immunotherapy for multiple sclerosis
In Multiple Sclerosis: Tissue destruction and repair. Kappos et al., (eds). Martin Dunitz Publishers, London, pp 233-244, 2001.
Jingwu Zhang
T cell vaccination in multiple sclerosis: Immunoregulatory mechanism and prospects for therapy (Invited review)
Critical Reviews of Immunology 21:41-55, 2001
Vipin Kumar, Eli Sercarz, Jingwu Zhang and Irun Cohen
T cell vaccination: From basics to the clinic.
Trends in Immunology 22:539-540, 2001
Jingwu Zhang
Clinical application of T cell vaccination: Clinical trials in multiple sclerosis.
In Autoimmunity and ierging Diseases L. Steinman (ed). Bialik Institute, Jerusali, pp 285-296, 2001.
Jingwu Zhang
T Cell Vaccination for Autoimmune Disease: Immunologic Lessons and Clinical Experience in Multiple Sclerosis (Invited review)
Expert Review of Vaccines 1:285-292, 2002.
Jingwu Zhang, George Hutton and Ying Zang (Invited review)
A comparison of the mechanisms of action of interferon beta and glatiramer acetate in the treatment of multiple sclerosis (Invited review)
Clinical Therapeutics 24:1998-2021, 2002
Jingwu Zhang
T Cell Autoimmunity and T Cell Vaccination. (Invited review)
Current Trends in Immunology 4: 87-94, 2002
Jingwu Zhang
Immunotherapies for multiple sclerosis (Invited review).
Research Progress in Multiple Sclerosis pp. 107-153, Ed. F. Columbus, Nova Science Publishers
Jingwu Zhang
T cell vaccination as an immunotherapy for autoimmune diseases.
Cellular and Molecular Immunology 1(5):321-7, 2004
Jingwu Zhang, George Hutton and Gholam Motamedi
Diyelinating and inflammatory diseases.
Neurology Pearls of Wisdom In M. Labanowski, Ed., Boston Medical Publishing Corp., Boston, 2004.
Jingwu Zhang, George Hutton.
Role of magnetic resonance imaging and immunotherapy in treating multiple sclerosis (Invited review).
Annual Review of Medicine 56:273-302, 2005
Jingwu Zhang
Paradoxical roles of interferon-γ in autoimmune disease (Invited review)
Expert Review of Clinical Immunology 3(1):35-38, 2007
Jingwu Zhang (Book Editor).
Immune Regulation and Immunotherapy in Autoimmune Disease.
Springer International, New York. pp569, 2007
Sheri Skinner and Jingwu Zhang
T cell vaccination in multiple sclerosis (Invited chapter)
Topics in Neuroimmunology Ed. F. Columbus, Nova Science Publishers, In press, 2007
Jingwu Zhang (Book Editor)
T cell vaccination: Mechanisms and clinical applications in autoimmune disease
Nova Science Publishers, In preparation, 2007
Jingwu Zhang (Invited chapter)
CD4+ regulatory T cells induced by T cell vaccination
Current Topics in Neuroimmunology, Ed. Tabira, In press, 2007
