肿瘤与血液免疫学研究组 研究组长 张雁云
徐凌云 研究员 研究组长
学习经历
1990－1995 山东医科大学 临床医学系
1997－2000 瑞典卡罗琳斯卡医学院博士
2001－2003 美国宾西法尼亚大学医学院博士
工作简历
1995－1996 青岛医学院附属医院神经科 住院医师
2003－至今 中国科学院上海生命科学院/上海第二医科大学健康科学研究所 研究员
主要成果
主要利用自身免疫病的实验动物模型，研究自身免疫反应的调节机理，并试验新的治疗方法。
所涉及的领域包括自身免疫性T细胞与神经系统的胶质细胞之间的相互作用；树突状细胞在自身免疫病中的作用；免疫决定簇肽与抗炎性细胞因子联合用药，通过粘膜耐受治疗自身免疫病；利用基因缺陷小鼠研究几类重要的转录分子（NF-KB/REL家族，p53家族等）在自身免疫病中的作用，等等。先后在国际学术期刊上发表论文十余篇。
主要论文
Li HY, Mei YH, Wang Y, L-Y Xu*. VIP suppresses EAE by inhibiting Th1 responses. J Clin Immunol. 2006. In press.
Wang Y, Mei YH, Feng D, L-Y Xu*. (-)-epigallocatechin-3-gallate protects mice from concanavalin A-induced hepatitis through suppressing immune mediated liver injury. Clin Exp Immunol. 2006; 145: 485.
Wang ZJ, Hong J, Sun W, Xu GW, Li NL, AL Liu, L-Y Xu, B Sun, Zang JW. Role of Gamma-Interferon in Induction of Foxp3 and Conversion of CD4+CD25- T cells to CD4+ Regulatory T Cells. J Clin Inv. 2006. In press.
Sun J, Hilliard B, L-Y Xu, Chen YH. Essential roles of the Fas-associated death domain in autoimmune encephalomyelitis. J Immunol. 2005; 175: 4783.
Fang Li, Yunhua Mei, Ying Wang, Chunhua Chen, Jianglong Tu, Baoguo Xiao, L-Y Xu* .Trichosanthin inhibits antigen-specific T cell expansion through nitric oxide-mediated apoptosis pathway. Cell. Immunol. 2005; 234: 23.
SJ Zheng, SE Lamhamedi-Cherradi, P Wang, L-Y Xu, YH Chen. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes. 2005 ;54:1423-8.
Yang JS, L-Y Xu, Xiao BG, Hedlund G, Link H. Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats. J Neuroimmunol. 2004;156:3-9.
Xiao BG, Wu XC, Yang JS, L-Y Xu, Liu X, Huang YM, Bjelke B, Link H. Therapeutic potential of IFN-gamma-modified dendritic cells in acute and chronic experimental allergic encephalomyelitis. Int Immunol. 2004;16:13-22.
SE Lamhamedi-Cherradi, S Zheng, BA Hilliard, L-Y Xu, J Sun, S Alsheadat, HC Liou, and YH Chen. Transcriptional regulation of type I diabetes by NF-kB. Journal of immunology. 2003;171:4886-92.
LY Xu, BA Hilliard, R J. Carmody, G Tsabary, H Shin, DW Christianson, and YH Chen. Roles of Arginase in Experimental Autoimmune Encephalomyelitis. Immunology. 2003;110:141-8.
BA Hilliard, N Mason, L-Y Xu, S Lamhamedi-Cherradi, H-C Liou, C Hunter and Y-H Chen. Critical role of c-rel in Autoimmune inflammation and helper T cell differentiation. J. Clin Invest. 2002; 110:843-50.
L-Y Xu, Yang JS, Xiao BG.TGF-beta1-conditioned glial cell-derived dendritic cells inhibit expansion of MBP-reactive T cells in vitro. Neuroreport. 2002; 13:35-9.
L-Y Xu, J-S Yang, H Link, and B-G Xiao. SIN-1, a nitric oxide donor, ameliorates EAE on the induction phase in Lewis rats: the importance of time window. J. Immunol. 2001; 166: 5810-5816.
J-S Yang, L-Y Xu, Y-M Huang, PH van der Meide, H Link, and B-G Xiao. Adherent dendritic cells expressing high levels of IL-10 and low levels of IL-12 induce antigen-specific tolerance to EAE. Immunology. 2000; 101:397-403.
Y-M Huang, J-S Yang, L-Y Xu, H Link and B-G Xiao. Autoantigen pulsed dendritic cells induce tolerance to experimental allergic encephalomyelitis in Lewis rats. Clin. Exp. Immunol. 2000; 122: 437-444.
L-Y Xu, J-S Yang, Y-M Huang , M Levi, H Link, and B-G Xiao. Combined nasal administration of encephalitogenic MBP peptide 68-86 and IL-10 suppressed ongoing EAE in Lewis rats. Clin. Immunol. 2000; 96: 205-211.
L-Y Xu, Y-M Huang, J-S Yang, P H. van der Meide, H Link, and B-G Xiao. Suppression of ongoing EAE in Lewis rats: synergistic effects of MBP peptide 68-86 and IL-4. Clin. Exp. Immunol. 2000; 120:526-531.
L-Y Xu, M Ishikawa, Y-M Huang, M Levi, P H. van der Meide, B Wahren, H Link, and B-G Xiao. The complexity of cytokine treatment in ongoing EAE induced with MBP peptide 68-86 in Lewis rats. Clin. Immunol. 2000; 95: 70-78.
Y-X Jin, L-Y Xu, H Guo, M Ishikawa, H Link, and B-G Xiao. TGF-b1 inhibit protracted-relapsing experimental autoimmune encephalomyelitis by activating dendritic cells. J. Autoimmunity. 2000; 14: 213-220.
B-G Xiao, L-Y Xu, J-S Yang, Y-M Huang, and H Link. An alternative pathway of nitric oxide production by astrocytes requires specific antigen and T cell contact. Nuerosci. Lett. 2000; 283: 53-56.
L-Y Xu, J-S Yang, Y-M Huang, PH. van der Meide, M Levi, B Wahren, H Link, and B-G Xiao. Limitation of nitric oxide production: spleen and lymph node exhibit distinct difference at nitric oxide induction. Immunol. Lett. 2000; 71:177-184.
L-Y Xu, Y-M Huang, J-S Yang, PH van der Meide, M Levi, B Wahren , H Link, and B-G Xiao. Dendritic cell-derived Nitric oxide is involved in IL-4-induced suppression of experimental allergic encephalomyelitis in Lewis rats. Clin Exp Immunol. 1999; 118: 115-121.
B-G Xiao, Y-M Huang, L-Y Xu, M Ishikawa and H Link. Mechanisms of recovery form experimental allergic encephalomyelitis induced with myelin basic protein peptide 68-86 in Lewis rats: The role of dendritic cells in inducing apoptosis of CD4+ T cells. J Neuroimmunol. 1999; 97:25-36.
