药物基因组学研究组 研究组长 马维骏 博士
马维骏 研究员 研究组长
wjma@sibs.ac.cn
学习经历
南京大学生物化学系学士
中科院上海药物研究所和美国密西根大学联合培养博士
美国Memorial Sloan-Kettering Cancer Center博士后
主要成果
(1)、成功进行重组钙离子通道α-亚基的克隆和功能表达，证明重组钙离子通道介导兴奋-分泌偶联。
(2)、利用基于进化分析的分类策略，确认了一个新的分泌蛋白OLF基因亚家族，并鉴别出此亚家族中的新成员。
(3)、率先克隆基因表达转录后调控蛋白Hu家族的唯一非组织特异因子，建立了该调控因子与mRNA转录后调控元件以及polyA之间的双联互作模型。揭示了此Hu蛋白在癌细胞内所参与的转录后调控作用。
(4)、识别、定位了果蝇天然免疫应答中起重要作用的抗菌肽基因的转录后调控元件。表明了转录后调控因子与RNA相互作用对免疫应答相关基因表达调控的重要意义。
主要论文
Zhaozhao Jiang, Haixu Chen, Yue Li, Wei-Jun Ma. Antibacterial peptide Drosocin mRNA interacts with Elav, suggesting a putative post-transcriptional regulation of the gene. Insect Biochemistry and Molecular Biology. In submission.
Ling-Chun Zeng, Ze-Guang Han, and Wei-Jun Ma. Elucidation of Subfamily Segregation and Intramolecular Coevolution of the Olfactomedin-like Proteins by Comprehensive Phylogenetic Analysis and Gene Expression Pattern Assessment. FEBS Letters. 2005; 579: 5443-5453.
Yue Li, Zhao-Zhao Jiang, Hai-Xu Chen, Wai-Keung Leung, Joseph JY Sung, Wei-Jun Ma. The existence of a putative regulatory element in 3’-untranslated region of the proto-oncogene hox11 mRNA.Journal of biochemistry and molecular biology.2005;38(4):500-6.
Bo Kong, Wei-Jun Ma. Display of aggregation-prone ligand binding domain of human PPAR gamma on surface of bacteriophage lambda. Acta Pharmacol Sin. 2006; 27(1):91-99.
Haixu Chen, Yue Li, Zhaozhao Jiang, Xianming Qu, Shengli Yang, Wei－Jun Ma. The existence of putative post-transcriptional regulatory element in 3’-UTR of drosophila antibacterial peptide diptericin’s mRNA. FEBS Letters. 2004; 561(1-3): 181-185.
Yue Li, Zhaozhao Jiang, Haixu Chen, Wei-Jun Ma. A modified quantitative EMSA and its application in the study of RNA-protein interactions. J Biochem Biophys Methods. 2004; 60(2): 85-96.
Ling-Chun Zeng, Feng Liu, Xin Zhang, Zhi-Dong Zhu, Zhi-Qin Wang, Ze-Guang Han, Wei-Jun Ma. hOLF44, a secreted glycoprotein with distinct expression pattern, belong to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis. 2004; FEBS Letters. 571(1-3 ): 74-80.
Wei-Jun Ma, Sangmi Chung, and Henry Furneaux. The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA. Nucleic Acids Res. 1997; 25(18): 3564-3569.
Wei-Jun Ma, and Henry Furneaux. Localization of the human HuR gene to chromosome 19p13.2. Hum Genet. 1997; 99:32-33.
Enhong Wang, Wei-Jun Ma, Carol Aghajanian, and David R. Spriggs. Post transcriptional regulation of protein expression in human epithelial carcinoma cells by AU-rich elements in the 3’UTR of TNF- mRNA. Cancer Research. 1997. 57:5426-5433.
Wei-Jun Ma, Simon Cheng, Chris Campbell, Anne Wright, and Henry Furneaux. Cloning and characterization of HuR, a ubiquitously expressed elav-like protein. J Biol Chem. 1996. 271(14): 8144-8151.
Wei-Jun Ma, Ronald W. Holz, and Michael D. Uhler. Expression of a cDNA for a neuronal calcium channel alpha 1 subunit enhances secretion from adrenal chromaffin cells. J Biol Chem. 1992; 267(32): 22728-22732.
