应用基因组学研究组 研究组长 张济
张济 研究员 研究组长
jizhang@sibs.ac.cn
学习经历
1986-1991 比利时鲁汶大学医学遗传学博士
1991-1993 美国密西根大学肿瘤基因组学博士后
工作简历
2002-至今 中国科学院上海生命科学研究院/上海第二医科大上海健康科学中心
应用基因组研究室 主任
2002-至今 上海血液学研究所医学基因组学部 主任
2000-2003 University Nebraska Medical Cente功能基因组学研究室 主任
2000-2003 美国德州Advanced Image Research Institute 顾问
1999-2003 University Nebraska Medical Center病理系 助理教授
1993-1999 NIH， National Genome Research Institute高资助研 课题组长
1982-1986 新疆医学院基础部 助教
荣誊(证书、称号、会员)
1989 比利时国家科学基金会优秀博士生资助奖
1995, 1996, 1998 美国国家健康院NHGRI年度杰出贡献奖
1999 美国国家健康院NHGRI VIP个人奖
主要成果
一、在技术和材料方面的主要创新包括率先利用微细胞融合法建立了仅含有人类12号短臂等臂染色体的人/鼠杂交系、利用原位杂技法定位一系列大鼠肾上腺相关疾病的基因以及利用PCR与人/鼠杂交细胞系相结合的方法进行高通量的基因定位等。这一方面的工作主要对于促进基因组学的发展起到了积极的作用。
二、在癌基因和抗癌基因的发现与研究方面，率先建立了BCR-ABL融合基因的细胞遗传学特异性的识别探针、克隆了实体瘤特异性的IGF1R内源性基因扩增以及克隆了肿瘤抑制基因Hic-5等。
三、在功能基因组学及生物信息学方面，建立了一套以CPP-SOM 为主体的独具特色的表达数据挖掘方法。该方法在挖掘基因组及蛋白质组表达数据的生物学意义方面与经典方法相比具有独特的优越性，其对于广泛推动功能基因组学及系统生物学的发展具有实质性的意义。
主要论文
Bai XT, Gu BW, Yin T, Niu C, Xi XD, Zhang J, Chen Z and Chen SJ. Trans-repressive effect of NUP98-PMX1 on PMX1-regulated c-FOS gene through recruitment of HDAC1 by FG repeats. Cancer Res 2006; 66(9):4584-4590
Du YZ, Wang KK, Fang H, Li JM, Xiao DK, Zheng PZ, Chen YL, Fan HY, Pan XL, Zhao CJ, Zhang QH, Imbeudd S, Graudens E, Eveno E, Auffray C, Chen SJ, Chen Z and Zhang J. Coordination of Intrinsic, Extrinsic and Endoplasmic Reticulum-Mediated Apoptosis by Imatinib Mesylate Combined with Arsenic Trioxide in Chronic Myeloid Leukemia. Blood 2006; 107(4):1582-1590
Zheng, P.Z., Wang, K.K,, Zhang, Q.Y., Huang, Q.H., Du, Y.Z., Zhang, Q.H., Xiao, D.K., Shen ,S.H., Imbeaud, S., Eveno, E., Zhao, C.J,, Chen, Y.L., Fan, H.Y., Waxman, S., Auffray, C., Jin, G., Chen, S.J., Chen, Z., Zhang, J. (2005) Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. PNAS 102, 7653-7658.
Xu, K., Glasow, A., Chung, D., Guidez, F., Stegmaier, K., Golub, T.R., Wang, K.K., Zhang, J., Zelent, A. and Waxman, S. (2005) Dithiophenes potentiate differentiation of APL cells by lowering the threshold for ligand mediated co-repressor/co-activator exchange with RARa and enhancing changes in ATRA regulated gene expression. Cancer Res 65 (17):7856-65.
Yin, T., Wu, YL., Sun, HP., Sun, GL., Du, YZ., Wang, KK., Zhang, J., Chen, GQ., Chen, SJ. & Chen, Z. (2004). Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein. Blood 2004 Dec 15;104(13):4219-25.
Xiao, L. Wang, KK, Teng, Y. & Zhang, J.(2003). Component plane presentation integrated self-organizing map for microarray data analysis. FEBS Letters 538, 117-124.
Zhang, J. (2003) Genomics and beyond. In H. Daniel and J. Zempleni (Eds), Molecular Nutrition.CABI, Inc., pp 1-13.
Bridge, J. A., Liu, J., Qualman, S., Suijkerbuijk, R., Wenger, G., Zhang, J., Wan, X., Baker, S., Sorensen, P. & Barr, F. (2002) Genomic Gains and losses are similar in genetic and histologic subsets of Rhabdomyosarcoma whereas amplification predominates in embryonal with anaplasia and Alveolar subtypes. Gene Chromosome and Cancer 33, 310-321
Zhang, J., Zhang, L.X., Barrett, J.C., Meltzer, P.S. & Trent, J.M. (2000). Full length cDNA, gene organization and chromosome localization of human Hic-5, a potential negative regulator involved in integrin mediated signal transduction and cell transformation. Molec. Carcinogen. 27, 177-183.
Zhang, J., Glatfelter, A.A., Taetle, R. & Trent, J.M. (1999). Frequent alterations of evolutionarily conserved regions of chromosome 1 in human malignant melanoma. Cancer Genet. Cytogenet. 111(2), 119-123.
Trent, J.M., Bittner, M., Zhang, J., Wiltshire, R., Ray, M., Su, Y., Gracia, E., Meltzer, P., De Risi, J., Penland, L. & Brown, P. (1997). Use of microgenomic technology for analysis of alterations in DNA copy number and gene expression in malignant melanoma. Clin Exp. Immunol. 107, Suppl 1, 33-40.
Hardas, B., Zhao, X., Zhang, J., Xia, L., Stoll, S. & Elder, J. (1996). Assignment of psoriasin to human chromosome band 1q21: Coordinate overexpression of clustered genes in psoriasis. J. Invest. Dermatol. 106, 753-758.
Zhang, J., Cui, P., Glatfelter, A.A., Cummings, L.M., Meltzer, P.S. & Trent, J.M. (1995). Microdissection based cloning of a translocation breakpoint in a human malignant melanoma. Cancer Res. 55, 4640-4645.
Hardas, B.D., Zhang, J., Trent, J.M. & Elder, J. (1994). Direct evidence for homologous sequences on the paracentric regions of human chromosome 1. Genomics 21, 359-363.
Leach, F.S., Nicolaides, N.C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R., Peltomaki, P., Sistonen, P., Aaltonen, L.A., Nystrom-Lahti, M., Guan, X., Zhang, J., et al., (1994). Mutation of a MutS homolog in hereditary non-polyposis colorectal cancer. Cell 75, 1215.
Zhang, J., Meltzer, P.S., Jenkins, R., Guan, X. & Trent, J.M. (1993). Application of chromosome microdissection probes for elucidation of BCR-ABL fusion and variant Philadelphia chromosome translocations in chronic myelogenous leukemia. Blood 81, 3365-3371.
Zhang, J., Trent, J.M. & Meltzer, P.S. (1993). Rapid isolation and characterization of amplified DNA by chromosome microdissection: Identification of IGF1R amplification in malignant melanoma. Oncogene 8, 2827-2831.
Zhang, J., Meltzer, P.S. & Trent, J.M. (1993). Application of chromosome microdissection for the isolation of a translocation breakpoint involving chromosome 6 in malignant melanoma. Cytogenet. Cell Genet. 62, 86.
Yu, H., Thun, R., Chandrasekharappa, S., Trent, J.M., Zhang, J. & Meisler, M.H. (1993). Human PCK1 encoding phosphoenolpyruvate carboxykinase is located on chromosome 20q13.2. Genomics 15, 219-221.
Zhang, J., Devriendt, K., Marynen, P., Van den Berghe, H. & Cassiman, J.J. (1990). Chromosome mapping using polymerase chain reaction on somatic cell hybrids. Cancer Genet. Cytogenet. 45, 217-221.
Zhang, J., Hemschoote, H., Peeters, B., De Clercq, N., Rombauts, W. & Cassiman, J.J. (1989). Localization of the PRR1 gene coding for rat prostatic proline-rich polypeptides to chromosome 10 by in situ hybridization. Cytogenet. Cell Genet. 52, 197-198.
Devriendt, K., Zhang, J., Van Leuven, F., Van den Berghe, H., Cassiman, J.J. & Marynen, P. (1989). A cluster of a2 macroglobulin-related genes on the human chromosome 12. Gene 81, 325-334.
Zhang, J., Marynen, P., Devriendt, K., Fryns, J.P., Van den Berghe, H. & Cassiman, J.J. (1989). Molecular analysis of the isochromosome 12p in the Pallister-Killian syndrome. Construction of a mouse-human hybrid cell line containing an i(12p) as the sole human chromosome. Hum. Genet. 83, 359-363.
Marynen, P., Zhang, J., Cassiman, J.J., Van den Berghe, H. & David, G. (1989). Partial primary structure of the 48- and 90-Kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. J. Biol. Chem. 264, 7017-7024.
Zhang, J., Dirckx, L., Marynen, P., Rombauts, W., Delaey, B., Van den Berghe, H. & Cassiman, J.J. (1988). Mapping of rat prostatic binding protein genes C1, C2 and C3 to rat chromosome 5 by in situ hybridization. Cytogenet. Cell Genet. 48, 121-123.
专著与综述
1. Zhang, J. Genomics and beyond. In H. Daniel and J. Zempleni (Eds), Molecular Nutrition. CABI, Inc.,
2003; pp 1-12.
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