发育与疾病研究组 研究组长 刘廷析
刘廷析 研究员 研究组长
txliu@sibs.ac.cn
学习经历
1985-1990 贵州省贵阳医学院临床医学系学士
1993-1996 湖北省武汉同济医科大学血液学研究所硕士
1996-1999 上海第二医科大学附属瑞金医院上海血液学研究所博士
1999-2004 美国哈佛大学医学院Dana-Farber肿瘤研究所博士后
工作简历
1990-1993 贵州省贵阳医学院附属医院内科住院医师
2004-至今 中国科学院上海生命科学研究院/上海第二医科大学健康科学研究所研究员
荣誊(证书、称号、会员)
1999 Clyde Wu Foundation，一等奖
1999 Federal Pharmaceutical Award
1999-2004 Leukemia and Lymphoma Society 博士后奖学金
2002 第44届美国血液学年会（ASH）Travel Award
2004 第44届美国血液学年会（ASH）Travel Award
2004 美国血液学会会员（ASH）
2004 贵州省贵阳医学院客座教授
2004 上海高校模式生物E-研究院特聘教授
2004 中国科学院“百人”计划
2005 国家杰出青年科学基金
2006 获上海浦江人才计划
主要成果
本实验室工作主要使用斑马鱼发育-疾病模式生物体，进行人类造血系统发育，造血干细胞和白血病肿瘤干细胞的分子遗传学研究和转化型医学研究。2000年，阐述急性早幼粒细胞白血病维甲酸诱导分化的分子网络调控机制。2002年，澄清人类5号染色体长臂5q31和5q32-34上两个白血病关键缺失区4.5亿年的进化规律。2003年，通过使用斑马鱼发育-疾病模式生物体，揭示人类遗传性白血病Fanconi贫血病人发育缺陷的分子遗传学机制。2006年，发现人类5号染色体长臂5q31白血病关键缺失区内的白血病肿瘤抑制基因。2004年回国前后，参与组织并完成由上海血液学研究所，健康科学研究所，哈佛大学医学院Dana-Farber肿瘤研究所和波士顿儿童医院四家单位组成的国际合作课题（获NIH资助），证明脊椎动物造血分子调控网络高度保守，为使用斑马鱼模式生物体对人类血液系统疾病进行转化型医学研究奠定重要基础。
主要论文
Liu TX, Becker MW, Jelinek J, Wu WS, Deng M, Mikhalkevich N, Hsu K, Bloomfield CD, Stone RM, Deangelo DJ, Galinsky IA, Issa JP, Clarke MF, Look AT. Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med. 2007 Feb;13(1):78-83.
Liu TX, Rhodes J, Deng M, Hsu K, Radomska HS, Kanki JP, Tenen DG, Look AT. Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish. Exp. Hematol. 2007 Feb;35(2):230-9.
Mathias JR, Perrin BJ, Liu TX, Kanki J, Look AT, Huttenlocher A. (2006) Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. J Leukoc Biol. 2006 Sep 8; [Epub ahead of print].
Rhodes J, Hagen A, Hsu K, Deng M, Liu TX, Look AT, Kanki JP. (2005) Mechanism of regional antagonism between hematopoietic transcriptional factors Pu.1 and Gata-1 in zebrafish. Developmental Cell. 8(1):97-108.
Berghmans S, Murphey RD, Wienholds E, Neuberg D, Kutok JL, Morris JP, Liu TX, Schulte-Merker S, Kanki JP, Plasterk R, Zon LI, Look AT. (2005) tp53 Mutant Zebrafish Develop Malignant Peripheral Nerve Sheath Tumors. Proc Natl Acad Sci USA. 102(2):407-412.
Song HD, Sun XJ, Deng M, Zhang GW, Zhou Y, Wu XY, Sheng Y, Chen Y, Ruan Z, Jiang CL, Fan HY, Zon LI, Kanki JP, Liu TX, Look AT, Chen Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proc Natl Acad Sci USA. 101(46):16240-16245.
Hsu K, Traver D, Kutok JL, Hagen A, Liu TX, Paw BH, Rhodes J, Berman J, Zon LI, Kanki JP, Look AT. (2004) The pu.1 promoter drives myeloid gene expression in zebrafish. Blood 104(5):1291-1297.
Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, Rhodes J, Kanki JP, D'Andrea AD, Look AT. (2003) Disruption of FANCD2 function causes congenital abnormalities through p53-dependent apoptosis during zebrafish embryogenesis. Developmental Cell. 5(6):903-914.
Liu TX, Zhou Y, Kanki JP, Deng M, Rhodes J, Yang HW, Sheng XM, Zon LI, Look AT. (2002) Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies. Proc Natl Acad Sci USA. 99(9): 6136-6141.
Bennett CM, Kanki JP, Rhodes J, Liu TX, Paw BH, Kieran MW, Langenau DM, Delahaye-Brown A, Zon LI, Fleming MD, Look AT. (2001) Myelopoiesis in the zebrafish, Danio rerio. Blood. 98(3): 643-651.
Liu TX, Zhang JW, Tao J, Zhang RB, Zhang QH, Zhao CJ, Tong JH, Lanotte M, Waxman S, Chen SJ, Mao M, Hu GX, Zhu L, Chen Z. (2000) Gene expression networks underlying retinoic acid-induced differentiation of acute promyelocytic leukemia cells. Blood. 96(4):1496-1504.
Liu TX, Mao M, Chen Z, Wang ZY. (1999) Acute promyelocytic leukemia: progress in the pathogenesis and mechanism of induced differentiation. Chinese J of Hematol. 19:29-30.
Liu TX, Liu XF. (1997) The development of hematopoietic progenitor cells and cytoadhesion molecules. Clinical J of Hematol. 10:79-81.
Liu TX, Liu XF, Zhou P. (1997) Study on the expression of adhesion molecules VLA-4, LFA-1 in acute myeloid leukemia: the feature of expression and its clinical implications. Clin J of Hematol. 10:152-154.
Liu TX, Liu XF, Xiang JP. (1997) Study on the relationship between the expression of adhesion molecules and the invasiveness of acute myeloid leukemia cells. Chinese J of Hematol. 18:29-30.
