实验室负责人照片:

中国科学院上海生命科学研究院计算生物学研究所  所长: Andreas Dress
组合数学与几何学实验室
Andreas Dress 教授，生于1938年，于1962年在德国基尔大学获自然科学博士学位，多年来一直是美国普林斯顿高等研究机构实验室的成员，并且从1969年开始在比勒费尔德大学（University of Bielefeld）工作，并领导该校的RCSF研究中心（Research Center for Studies on Structure Formation），培养出一大批优秀人才，是德国最有影响的组合数学家。Dress 教授在世界上多所知名的大学和实验室担任客座科学家，同时也是7本国际性专业杂志的联合主编。

Dress教授的研究领域涉及组合数学、组合几何学、图论、化学、生物数学、分子进化，以及拓扑方法在蛋白质组学以及计算化学的应用、应用软件等。曾在《Science》，《Nature》和《Annals of Mathematics》等国际最权威的杂志上发表多篇论文。

Tel: +86 21 54920452
E-mail:dress@sibs.ac.cn

Dress教授曾在各类科学杂志期刊上发表了270多篇学术论文，研究领域包括几何学、代数学、拓扑学、分子进化学、计算生物学、组合学、拓扑化学及图像处理。

他曾在德国Oberwolfach数学研究所和萨尔洲的瓦登-达格施杜信息研究中心组织过多次学术会议，范围涉及代数K-理论、组合几何学和近似学理论。另外，他还在德国Bad Honnef物理中心和比勒菲尔德交叉学科研究中心(ZIF) 组织过多个学术会议，范围包括结晶图形、拓扑化学、计算和理论生物学等。

Dress教授早期的工作致力于解决纯数学的问题，从基础几何学到数论、拓扑、替换、代数…以及对有限和次有限集合的正则表达理论。他与Manfred Eigen合作解决了分子进化和计算生物学的相关问题，奠定了相似/相异的正则数学理论的基础，被广泛应用于系统发生学领域。此后，他与生物学界开始进行更多的接触与合作，使数学和生物信息学、基因组学紧密地联系起来。

近年来，Dress教授还开展了图形处理和图像合成方面的研究工作，它们广泛应用于最优化理论中的组合学和离散数学、结晶图形、化学、医学以及纯数学中的古典代数学和丢番图逼近。 

最新研究方向:

1、组合学在系统发生学中的应用 combinatorics—with special emphasis on “Phylogenetic Combinatorics”

2、计算生物学—分子进化 Computational Biology—with special emphasis on “Molecular Evolution”

3、拓扑蛋白学组学—细胞中蛋白质网络的空间组织与它们和细胞功能状态间的关系 Topological Proteomics—with special emphasis on the spatial organization of cellular protein networks and their relation to a cell’s functional state.

4、计算化学中的拓扑方法 Topological Methods in Computational Chemistry

5、应用代数 Applied Algebra

6、蛋白质组学—用多维荧光图象检测特定的疾病蛋白质的模式 Proteomics—with special emphasis on “Detection of Disease-specific Protein Motivs in Multivariate Fluorescence Image
 
个人简介 
1962 德国基尔大学博士毕业

1965 基尔大学Habilitation

1965-1969 柏林自由大学研究员

1967/8-1968/9在普林斯顿大学交叉学科研究所中心进行为期1年的学习。

1969年被聘为比勒菲尔德大学数学系全职教授，在此一直工作到2003年。期间还被许多其他的著名大学或研究所邀请做访问学者。如e.g.IAS/Princeton ,UBC/Vancouver, Queen Mary College/London, IBM/Heidelberg, ETHZ/Zuerich, Mittag-Leffler-Institut/Stockholm, Scripps Research Institute/La Jolla, RIMS/Kyoto, the University of Canterbury/Christchurch-NZ, Massay University/Palmerston North-NZ, Academia Sinica Chengdu Labaratories/Sichuan-China, the Department of Chemical Engineering/City College/New York  等等

2003年9月1日，开始在马普学会莱比锡数学科学研究所工作。2005年10月被选聘为中国第一个计算生物学研究所-----中国科学院—马普学会计算生物学伙伴研究所的所长之一，主持研究所的科研工作。他的研究室主要从事组合数学与几何学的研究。

Dress教授曾在Advances in Mathematics, Acta Applicandae Math., Appl. Math.Letters, Communications in Mathematical and Computer Chemistry (MATCH), Contributions to Geometry and Algebra, Annals of Combinatorics, Journal of Computational Biology等学术期刊发表论文270多篇。
 
学术论文
最近几年中发表的重要文章：
[1] I.A. Syed, M. Rehmsmeier, A. Dress G. F¨ullen: Comparative homology agreement search: An effective combination of homology-search methods. PNAS Vol. 38, pp 13814-13819 (2004).

[2] Olaf Delgado Friedrichs, Andreas W. M. Dress, Daniel Huson, Jacek Klinowski, Alan Mackay: Systematic enumeration of crystalline networks. Nature, Vol. 400, pp 644-647 (1999).

[3] Hermann Ragg, Tatjana Lokot, P.B. Kamp, William R. Atchley, Andreas W. M. Dress: Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. Molecular Biology and Evolution, Vol. 18, pp 577-584 (2001).

[4] Tianbo Liu, Ekkehard Diemann, Huilin Li, Andreas W. M. Dress, Achim M¨uller: Self-assembly in aequeous solution of wheel-shaped Mo154 oxide clusters into vesicles, Nature 426, pp 59-61 (2003).

[5] Andreas W. M. Dress: Recent Results and New Problems in Phylogenetic Combinatorics. In: La ciencia y la tecnologia ante el Tercer Milenio (I), pp 143-162, Sociedad Estatal Espana Nuevo Milenio, ed. J.M.S.Ron, Madrid (2002).

[6] Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: An explicit computation of the injective hull of certain finite metric spaces in terms of their associated Buneman complex. Advances in Mathematics, Vol. 168, Iss 1, pp 1-28 (2002).

[7] Achim Muller, E. Beckmann, H. Bogge, M. Schmidtmann, Andreas W. M. Dress: Inorganic chemistry goes protein size: A Mo-368 nano-hedgehog initiating nanochemistry by symmetry breaking. Angewandte Chemie — International Edition, Vol. 41, pp 1162-1164 (2002).

[8] Andreas W. M. Dress, Stefan Gr¨unewald, Ivan Gutman, Mirko Lepovi′c, and Duˇsica Vidovi′c: On the number of Walks in Trees. Communications in Mathematical and Computer Chemistry (=MATCH), Vol. 48, pp 63-85 (2003).

[9] Andreas W. M. Dress, Dragan Stevanovi′c: Hoffman-type Identities. Applied Mathematics Letters, Vol. 16, pp 297-302 (2003).

[10] Intikhab Alam Syed, Andreas Dress, and Georg Fuellen: CHASE, an Effective Combination of Homology-Search Methods. Preprint-Reihe des FSPM, Vol. 153, pp 1-25 (2003).

[11] Andreas W. M. Dress, T. Lokot: A Simple Proof of the Triangle Inequality for the NTV Metric. Applied Mathematics Letters, Vol. 16 (2003).

[12] Andreas W. M. Dress,Ivan Gutman: On the Number of Walks in a Graph. Applied Mathematics Letters, Vol. 16, pp 797-801 (2003).

[13] Andreas W. M. Dress, Ivan Gutman: Asymptotic Results Regarding the Number of Walks in a Graph. Applied Mathematics Letters, Vol. 16, pp 389-393 (2003).

[14] Burkhard Morgenstern, S. Goel, Alexander Sczyrba, Andreas W. M. Dress: AltAVisT : A www Tool for Comparison of Alternative Multiple Alignments. Bioinformatics, Vol. 19, pp 425–426 (2003).

[15] Dietmar Cieslik, Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: Connectivity Calculus. Applied Mathematics Letters, Vol. 16, pp 395-99 (2003).

[16] Jockusch H, Andreas W. M. Dress: From Sphere to Torus: A Topological Viewof the Metazoan Body Plan. Bulletin of Mathematical Biology, Vol. 65, pp 57-65 (2003).

[17] Barbara Holland, Katharina T. Huber, Andreas W. M. Dress, Vincent Moulton: ! plots: A tool for analyzing phylogenetic distance data. Molecular Biology and Evolution, Vol. 19, pp 2051-2059 (2003).

[18] Andreas W. M. Dress, Jack Koolen, Vincent Moulton: On line arrangements in the hyperbolic plane. The European Journal of Combinatorics, Vol. 23, pp 549- 557 (2002).

[19] Andreas W. M. Dress: Proper Gromov transforms of metrics are metrics. Applied Mathematics Letters, Vol. 15, pp 995-999 (2002).

[20] Dietmar Cieslik, Andreas W. M. Dress, Walter Fitch: Steiner’s problem in double trees. Applied Mathematics Letters, Vol. 15, pp 855-860 (2002).

[21] Burkhard Morgenstern, Rinner O, Abbeddaim S, Haase D, Mayer KFX, Andreas W. M. Dress, Mewes HW: Exon discovery by genomic sequence alignment. Bioinformatics, Vol. 18, pp 777-787 (2002).

[22] Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: An explicit computation of the injective hull of certain finite metric spaces in terms of their associated Buneman complex. Advances in Mathematics, Vol. 168, pp 1-28 (2002).

[23] Achim M¨uller, Beckmann E, Bogge H, Schmidtmann M, Andreas W. M. Dress: Inorganic chemistry goes protein size: A Mo-368 nano-hedgehog initiating nanochemistry by symmetry breaking. Angewandte Chemie — International Edition, Vol. 41, pp 1162-1164 (2002).

[24] Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: Antipodal metrics and split systems. The European Journal of Combinatorics, Vol. 23, Iss 2, pp 187-200 (2002).

[25] Andreas W. M. Dress: Recent Results and New Problems in Phylogenetic Combinatorics. In: La ciencia y la tecnologia ante el Tercer Milenio (I), pp 143-162, Sociedad Estatal Espana Nuevo Milenio, ed. J.M.S.Ron, Madrid (2002).

[26] Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: Metric Spaces in Pure and Applied Mathematics. Documenta Mathematica, Extra Volume: Proceedings of the Conference on Quadratic Forms and Related Topics, LSU - 2001, 121–139 (2001).

[27] Achim M¨uller, Paul K¨ogerler, Andreas W. M. Dress: Giant metal-oxide-based spheres and their topology: from pentagonal building blocks to keplerates and unusual spin systems. Coordination Chemistry Reviews, Vol. 222, pp 193-218 (2001).

[28] Andreas W. M. Dress, Katharina T. Huber, Jack Koolen, Vincent Moulton: Six points suffice: How to check for metric consistency. The European Journal of Combinatorics, Vol. 22, pp 465-474 (2001).

[29] Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: Totally split-decomposable metrics of combinatorial dimension two. The Annals of Combinatorics, Vol. 5. (2001).

[30] William R. Atchley, Tatjana Lokot, Kurt Wollenberg, Andreas W. M. Dress, Hermann Ragg: Phylogenetic analyses of amino acid variation in the serpin proteins. Molecular Biology and Evolution, Vol. 18, pp 1502-1511 (2001).

[31] Katharina T. Huber, Vincent Moulton, Peter Lockhart, Andreas W. M. Dress: Pruned median networks: A technique for reducing the complexity of median networks. Molecular Phylogenetics and Evolution, Vol. 19, pp 302-310 (2001).

[32] Hermann Ragg, Tatjana Lokot, P. Kamp, William R. Atchley, AndreasW.M. Dress: Vertebrate serpins: Construction of a conflict-free phylogeny by combining exonintron and diagnostic site analyses. Molecular Biology and Evolution, Vol. 18, pp 577-584 (2001).

[33] Sebastian B¨ocker, Andreas W. M. Dress: Patchworks. Advances in Mathematics, Vol. 157, pp 1-21 (2001).

[34] Sebastian B¨ocker S, David Bryant, Andreas W. M. Dress, Michael A. Steel: Algorithmic aspects of tree amalgamation. Journal of Algorithms, Vol. 37, pp 522-537 (2001).

[35] Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: Hereditarily Optimal Realizations: Why are they relevant in phylogenetic analysis, and how does one compute them? In: Algebraic Combinatorics and its Applications (Alcoma 99), Springer-Verlag, pp 110-117 (2000).

[36] Andreas W. M. Dress, Florian Luca: A Characterization of Certain Binary Recurrence Sequences. In: Algebraic Combinatorics and its Applications (Alcoma 99), Springer-Verlag, pp 89-101 (2000).

[37] Andreas W. M. Dress, Florian Luca: Unbounded Integer Sequences A(n)n ! 0 with A(n)A(n) ? A(n + 1)A(n ? 1) Bounded are of Fibonacci Type. In: Algebraic Combinatorics and its Applications (Alcoma 99), Springer-Verlag, pp 102-109 (2000).

[38] Michael A. Steel, Andreas W. M. Dress, Sebastian B¨ocker: Simple but fundamental limitations on supertree and consensus tree methods. Systematic Biology, Vol. 49, pp 363-368 (2000).

[39] Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: Affine maps that induce polyhedral complex isomorphisms. Discrete and Computational Geometry, Vol. 24, pp 49-60 (2000).

[40] Sebastian B¨ocker, Andreas W. M. Dress: A note on maximal hierarchies. Advances in Mathematics, Vol. 151, pp 270-282 (2000).

[41] Andreas W. M. Dress: Das Problem der Rekonstruktion phylogenetischer B¨aume aus der Sicht der Mathematik. In: Mathematik - Interdisziplin¨ar, Shaker Verlag, ISBN: 3-8265-7061-8, eds. J¨urgen Flachsmeyer, Rudolf Fritsch, Hans-Christian Reichel (2000).

[42] Andreas W. M. Dress:Beweis und Begriff – Zur Kreativitaet in der Mathematik. In: Kreatives Denken und Innovationen in den mathematischen Wissenschaften, Jenaer Schriften zur Mathematik und Informatik, ed. Bernd Zimmermann et al. (2000)

[43] William R. Atchley, Kurt Wollenberg, Walter M. Fitch, Werner Terhalle, Andreas W. M. Dress: Correlations among amino acid sites in bHLH protein domains: An information theoretic analysis. Molecular Biology and Evolution, Vol. 17, pp 164- 178 (2000).

[44] Andreas W. M. Dress: The Theorem of the k-1 Happy Divorces. The Annals of Combinatorics, Vol. 4, pp 183-194 (2000).

[45] Andreas W. M. Dress, Gottfried J¨ager (Hrsg.): “Visualisierung in Mathematik, Technik und Kunst. Grundlagen und Anwendungen” mit 11 Beitr¨agen aus diesen Bereichen. Vieweg Verlag, Braunschweig/Wiesbaden ISBN 3-528-06912-0 (1999).

[46] Martin A. Nowak, Krakauer DC, Andreas W. M. Dress: An error limit for the evolution of language. Proceedings of the Royal Society of London, Series B Biological Sciences, Vol. 266, pp 2131-2136 (1999).

[47] Sebastian B¨ocker, Andreas W. M. Dress, Michael A. Steel: Patching Up X-Trees. The Annals of Combinatorics, Vol. 3, 1-12 (1999).

[48] Olaf Delgado Friedrichs, Andreas W. M. Dress, Daniel Huson, Jacek Klinowski, Alan Mackay: Systematic enumeration of crystalline networks. Nature, Vol. 400, pp 644-647 (1999).

[49] Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: An Exceptional Split Geometry. The Annals of Combinatorics, Vol. 4, 1-12 (1999).

[50] Atchley WR, Terhalle W, Andreas W. M. Dress: Positional dependence, cliques, and predictive motifs in the bHLH protein domain. Journal of Molecular Evolution, Vol. 48, pp 501-516 (1999).

[51] Andreas W. M. Dress, Achim Flammenkamp, Norbert Pink: Additive periodicity of the Sprague-Grundy function of certain Nim games. Advances in Applied Mathematics, Vol. 22, pp 249-270 (1999).

[52] Gunnar Brinkmann, Andreas W. M. Dress: PentHex puzzles – A reliable and effi- cient top-down approach to fullerene-structure enumeration. Advances in Applied Mathematics, Vol. 21, pp 473-480 (1998).

[53] Sebastian B¨ocker, Andreas W. M. Dress: Recovering symbolically dated, rooted trees from symbolic ultrametrics. Advances in Mathematics, Vol. 138, Iss 1, pp 105-125 (1998).

[54] J. Kastner, A. Borobia, Andreas W. M. Dress, Christian Zylka: Extremal majorizing and anti-majorizing matrices. Linear Algebra and its Applications, Vol. 278, pp 133-145 (1998).

[55] Nicolai P. Dolbilin, Andreas W. M. Dress, Daniel H. Huson: Two finiteness theorems for periodic tilings of d-dimensional euclidean space. Discrete and Computational Geometry, Vol. 20, pp 143-153 (1998).

[56] Burkhard Morgenstern, K. Frech, Andreas W. M. Dress, Thomas Werner: DIALIGN: Finding local similarities by multiple sequence alignment. Bioinformatics, Vol. 14, pp 290-294 (1998).

[57] Andreas W. M. Dress: Datenstrukturen und virtuelle Welten – Vom Erfindungsreichtum der Mathematik, Mitteilungen der DMV (1998).

[58] Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: Some New Perspectives Regarding Sparse Continuous Models for Discrete Data Structures. The Electronic Journal of Discrete Mathematics, Vol. 2 (1998).

[53] Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: A Comparison between two distinct continuous models in projective cluster theory: The median and the tight-span construction. The Annals of Combinatorics, Vol. 2 (1998).

[59] Andreas W. M. Dress, Werner Terhalle: The Tree of Life and Other Affine Buildings, Documenta Mathematica, Extra Volume: Proceedings of the International Congress of Mathematicians, Berlin - 1998, pp 565-574 (1998).

正在印刷中的文章：
[1] Andreas W. M. Dress, Peter Erdoes: X-trees and Weighted Quartet Systems. The Annals of Combinatorics, to appear.

[2] Andreas W. M. Dress, Robert Giegerich, Stefan Gr¨unewald, Holger Wagner: Fibonacci-Cayley Numbers and Repetition Patterns in Genomic DNA. The Annals of Combinatorics, to appear.

[3] Andreas W. M. Dress, Fritz von Haeseler: A semigroup approach to automaticity. The Annals of Combinatorics, to appear.

[4] Andreas W. M. Dress, Stefan Gr¨unewald: Semiharmonic trees and monocyclic graphs. Applied Mathematics Letters, to appear.

[5] Andreas W. M. Dress, Stefan Gr¨unewald, Dragan Stevanovi′c: Semiharmonic graphs with fixed cyclomatic number. Applied Mathematics Letters, to appear.

[6] Andreas W. M. Dress,Ivan Gutman: On the Number of Walks in a Graph. Applied Mathematics Letters, to appear

[7] Andreas W. M. Dress, T. Lokot, Lev D. Pustyl’nikov: A New Geometry for L1-spaces. Applied Mathematics Letters, to appear.

[8] Claudine Devauchelle, Andreas Dress, Alexander Grossmann, Stefan Gr¨unewald, Alain Henaut: Constructing Hierarchical Set Systems. The Annals of Combinatorics, to appear.

[9] Andreas W. M. Dress, T. Lokot: A Simple Proof of the Triangle Inequality for the NTV Metric. Applied Mathematics Letters, to appear.

[10] Dietmar Cieslik, Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: Embedding Complexity and Discrete Optimization I: A New Divide and Conquer Approach to Discrete Optimization. The Annals of Combinatorics, to appear.

[11] Dietmar Cieslik, Andreas W. M. Dress, Katharina T. Huber, Vincent Moulton: Embedding Complexity and Discrete Optimization II: A Dynamical Programming Approach to the Steiner-Tree Problem. The Annals of Combinatorics, to appear.

[12] Barbara Holland, Katharina T. Huber, Andreas W. M. Dress, Vincent Moulton, Jack Koolen, Jan Weyer-Menkhoff: ! additive and ! ultra-additive maps, Gromov’s trees and the Farris transform. The Annals of Combinatorics, to appear.