中国科学院上海生命科学研究院计算生物学研究所 所长: 金力
调控基因组学实验室
金力教授生于1963年，1985年9月复旦大学生物系遗传专业本科毕业，1987年7月复旦大学遗传所遗传学专业硕士毕业，1994年获得美国德克萨斯-休斯顿大学生物医学科学/遗传学博士学位，1994年6月至1996年12月在美国斯坦福大学医学院遗传学专业从事博士后研究。曾任德克萨斯-休斯顿大学生物医学科学研究生院人类分子遗传专业副教授、德克萨斯-休斯顿大学公共健康院人类遗传学中心副教授，美国辛辛那提大学环境健康系基因组信息中心教授。现任是上海复旦大学生命科学院院长，复旦大学人类学研究中心主任。他的主要研究领域是人类遗传学、医学遗传学，群体遗传学以及基因组学和生物信息学。
Tel: +86 21 54920453
E-mail:lijin@sibs.ac.cn
研究方向: 群体遗传学
1.群体的遗传结构研究 (Developing approaches for exploring the genetic structure of populations)
2.人类复杂疾病遗传研究 (Mapping genes underlying human diseases with complex causes)
3.生物网络构建研究 (Reconstructing biological networks)
4.代谢途径控制模型研究 (Metabolic pathways, and modeling the controls of such networks)
目前承担及参与主要项目共3项，其中：国家级2项，部（省）级1项
中华民族基因组结构与功能研究 863项目 2002－2005 参与
环境化学污染物致机体损伤及其防御的基础研究 973项目 2002－2007 主持
心血管等重大疾病相关的生物系统网络结构及其动力学研究 上海市科委重大项目
2004－2007 主持近五年在国内外重要刊物上发表论文共125篇。
获奖情况
1998 杰出青年基金B类 教育部
1998 科技进步二等奖 教育部
1998-2001 优秀研究奖 德克萨斯大学公共卫生学院
1999-2001 优秀学者奖 德克萨斯大学公共卫生学院
2000 院长奖 德克萨斯大学-休斯顿健康科学中心
2000 教育部特聘长江讲座教授 教育部
2003 科技进步一等奖 教育部
2004 校长奖 复旦大学
2005 科技进步一等奖 上海市
指导研究生情况
近五年来（含已毕业和在培）
复旦大学遗传所及现代人类学中心 研究生35名 博士后5名
美国德州大学休斯敦健康科学中心 研究生7名 博士后 6名
美国辛辛纳提大学 研究生4名 博士后6名
个人简介
81 – 88 复旦大学遗传学专业本科生、硕士生、博士生
88 – 90 德克萨斯大学休斯顿健康科学中心人口统计及群体遗传学中心工作人员助理
90 – 94 德克萨斯大学休斯顿健康科学中心研究生院 博士研究生 （生物医学/遗传学）
94 – 96 斯坦福大学医学院遗传学系博士后
97 – 00 德克萨斯大学休斯顿公共卫生学院人类遗传中心助理教授
97 – 01 德克萨斯大学休斯顿生物医学研究生院助理教授、副教授
97 – 复旦大学遗传所人类群体遗传学及复杂疾病实验室兼职教授
99 – 04 中国人类基因多样性委员会秘书
00 – 01 德克萨斯大学休斯顿公共卫生学院人类基因中心副教授（终身教职）
01 – 05 辛辛那提大学医学院环境卫生系基因组信息中心教授 （终身教职）
01 – 05 辛辛那提大学医学院基因型分型平台主任
02 – 05 辛辛那提大学医学院功能基因组及基因芯片平台主任
02 – 复旦大学现代人类学研究中心主任
02 – 中国社会科学院中国古文明研究中心客座研究员
03 – 复旦大学生命科学学院院长
05 – 中科院-马普学会计算生物学伙伴研究所所长
近期论文
Selected Publications:
1. Chu JY, Huang W, Kuang SQ, Wang JM, Xu JJ, Chu ZT, Yang ZQ, Lin KQ, Li P, Wu M, Geng ZC, Tan CC, Du RF, Jin L. Genetic relationship of populations in China. PNAS. 95:11763-11768, 1998
2. Su B, Xiao J, Lu D, Chakraborty R, Jin L. An HIV-resistant allele is exceptionally frequent in New Guinean highlanders. JAMA 280:1830, 1998.
3. Jin L, Underhill PA, Doctor V, et al. Distribution of haplotypes from a chromosome 21 region distinguishes multiple prehistoric human migrations. PNAS 96:3796-3800, 1999
4. Xiong M, Jin L. Comparison of the power and accuracy of biallelic and microsatellite markers in population-based gene-mapping methods. Am J Hum Genet 64:629-40, 1999
5. Hacia JG, J-B Fan, O Ryder, L Jin, et al. Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonulceotide arrays. Nat Genet 22:164-167, 1999
6. Su B, Jin L et al. Distribution of Two HIV-1 Resistant Polymorphisms in East Asia and World Populations and Its Implication in AIDS Epidemiology. Am J Hum Genet 65:1047-1053, 1999
7. Su B, Xiao J, Underhill P, Deka R, Zhang W, Akey J, Huang W, Shen D, Lu D, Luo J, Chu J, Tan J, Shen P, Davis R, Cavalli-Sforza LL, Chakraborty R, Xiong M, Du R, Oefner P, Chen Z, Jin L. Y chromosome Evidence for a northward migration of modern humans in East Asia during the last Ice Age. Am J Hum Genet 65: 1718-1724, 1999
8. Xiong M, Jin L. Combined linkage and linkage disequilibrium mapping for genome screens. Genetic Epidemiology. 19:211-234, 2000.
9. Jin L, et al. A comparison of two microsatellite data sets from the same human populations. Ann Hum Genet. 64:117-134, 2000.
10. Su B, Jin L, et al. Polynesian origins: new insights from the Y-chromosome. PNAS 97:8225-8228, 2000.
11. Zhao Z, Jin L, et al. Worldwide DNA sequence variation in a 10 kb noncoding region on human chromosome 22. PNAS 97:11354-11358, 2000.
12. Xiong M, Jin L, Li W, Boerwinkle E. Computational Methods for Gene Expression-Based Tumor Classification. Biotechniques 29:1264-1270, 2000.
13. Underhill PA, Shen P, Lin AA, Jin L, et al. Y Chromosome Sequence Variation and the History of Human Populations. Nature Genet 26:358-361, 2000.
14. Su B, Xiao C, Deka R, Seielstad MT, Kangwanpong D, Xiao J, Lu D, Underhill P, Cavalli-Sforza LL, Chakraborty R, Jin L. Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. Hum Genet 107:582-590, 2000.
15. Jin L, Su B. Natives or immigrants : origin and migrations of modern humans in East Asia. Nature Rev Genet 1:126-133, 2001
15. Ke Y, Su B, Song X, Lu D, Marzuki S, Deka R, Wells RS, Lell J, Wallace D, Seielstad M, Martinson J, Shriver MS, Huang W, Chakraborty R, Underhill PA, Chen Z, Jin L. 2000. African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes. Science 292:1151-1153.
17. Jiang Z, Akey J, Shi J, Xiong M, Wu H, Xiao J, Lu D, Huang W, Jin L. A polymorphism in the promoter region of catalase is associated with blood pressure levels. Hum Genet 109:95-98. 2001.
18. Akey JM, Zhang K, Xiong M, Jin L. The affect of genotyping errors on the robustness of common linkage disequilibrium measures. Am J Hum Genet 68: 1147-1456. 2001.
19. Xiong M, Li W, Zhao J, Jin L, Boerwinkle E. Feature (Gene) Selection in Gene Expression Based Tumor Classification. Mol Biol Metab 73:239-247. 2001.
20. Jin L, Su B. The Y chromosome and the replacement hypothesis – Response. Science 293: 567-567B.2001.
21. Xiong M, Fan R, Jin L. 2002. Linkage disequilibrium mapping of quantitative trait loci under truncation selection. Hum Hered. 53:158-172.
22. Akey DT, Akey JM, Zhang K, Jin L. 2002. High-throughput melting curve based approaches to assay DNA methylation. Genomics 80:376-384.
23. Wang N, Josh AM, Zhang K, Chakraborty R, Jin L. 2002. Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation. Am J Hum Genet 71:1227-1234.
24. Akey JM, Zhang G, Zhang K, Jin L, Shriver MD. 2002. Interrogating a high-density SNP map for signatures of natural selection. Genome Res. 12:1805-1814.
25. Akey JM, Wakeley J, Zhang K, Xiong M, Jin L. 2003. The effect of single nucleotide polymorphism identification strategies on estimates of linkage disequilibrium. Mol Biol Evol. 20:232-242.26. Zhang K, Akey JM, Wang N, Xiong M, Chakraborty R, Jin L. 2003. Randomly distributed crossovers may generate block-like patterns of linkage disequilibrium: an act of genetic drift. Hum Genet 113:51-59.
27. Zhang K, Jin L. 2003. HaploBlockFinder: An efficient program for haplotype block analyses. Bioinformatics 19:1-3.
28. Shi J, Xi H, Wang Y, Zhang C, Jiang Z, Zhang K, Shen Y, Jin L, Zhang K, Yuang W, Wang Y, Lin J, Hua Q, Wang F, Xu S, Ren S, Xu S, Zhao G, Chen Z, Jin L, Huang Wei. 2003. Divergence of the genes on human chromosome 21 between human and other hominoids and variation of substitution rates among transcription units. PNAS 100: 8331-6.
29. Wen B, Xie X, Gao S, Li H, Shi H, Song X, Qian T, Xiao C, Jin J, Su B, Lu D, Chakraborty R, Jin L. 2004. Analysis of genetic structrure of Tibeto-Burman populations revealed a gender-biased admixture in Southern Tibeto-Burmans. Am J Hum Genet 74:856-865.
30. Zhang G, Luo J, Bruckel J, Weisman M, Schumacher HR, Khan MA, Inman R, Mahowald M, Maksymowych W, Martin TM, Yu DTY, Stone M, Rosenbaum JT, Newman P, Lee J, McClain JA, West OC, Jin L, Reveille J. 2004. Genetic studies in familial ankylosing spondylitis susceptibility. Arthritis and Rheumatism 50:2246-2254.
31. Wen B, Li H, Lu D, Song X, Zhang F, He Y, Li F, Gao Y, Mao X, Zhang L, Qian J, Tan J, Jin J, Huang W, Deka R, Su B, Chakraborty R, Jin L. 2004. Genetic evidence supports demic diffusion of Han culture. Nature 431:302-305
32. Jin L, Weisman MA, Zhang G, Akey JM, Bruckel J, Inman RD, Luo J, Khan MA, Schumacher HR, Maksymowych WP, Mahowald ML, Sawitzke AD, Wasey FB, Yu DTY, Stone MA, Lee J, Reveille JD. 2004. Lack of association and linkage of IL1RN genotypes with ankylosing spondylitis susceptibility. Arthritis and Rheumatism 50:3047-3048.
33. Jiang Z, Dalton TP, Jin L, Wanb B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW. 2005. Toward the evaluation o function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. Human Mutation 25:196-206.
34. Wang Y, Qian Y, Yang S, Shi H, Liao C, Zheng H, Wang J, Lin A, Cavalli-Sforza LL, Underhill PA, Chakraborty R, Jin L, Su B. 2005. Accelerated evolution of the PACAP precursor gene during human origin. Genetics (In Press).
35. Shi H, Dong YL, Wen B, Xiao CJ, Underhill PA, Shen PD, Chakraborty R, Jin L, Su B. 2005. Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122. Am J Hum Genet 77:408-419.
36. Jiang Z, Zhang X, Deka R, Jin L. 2005. Genome amplification of single sperms using multiple displacement amplification. Nucleic Acid Res 33.
37. Zhang F, Li Z, Wen B, Jiang J, Shao M, Zhao Y, He Y, Song X, Qian J, Lu D, Jin L. 2005. A frequent partial AZFc deletion does not render an increased risk of spermatogenic impairment in East Asians. Ann Hum Genet. (Published online).
38. Li Y, Zhang D, Jin W, Li Q,Xu C, Sheng H, Liu Y, Yu J, Yan P, Xie Y, Zhao Y, Lu D, Nebert DW, Harrison DC, Huang W, Jin L. 2005. Mitochondrial aldehyde dehydrogenase (ALDHs) Glu487Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. J Clin Inv (In Press).
39. Huang W, He Y, Wang H, Wang Y, Liu Y, Wang Y, Chu X, Wang Y, Xu L, Shen Y, Xiong X, Li H, Wen B, Qian J, Yuan W, Zhang C, Wang Y, Jiang H, Zhao G, Chen Z, Jin L. 2005. Linkage disequilibrium sharing and tagSNPs portability between populations. PNAS. (In Press).
40. Jiang Z, Dragin D, Martin MV, Guengerich FP, Aklillu E, Ingelman-Sundberg M, Hammons J, Lyn-Cook BD, Kadlubar FF, Saldana SN, Sorter M, Winks AA, Nassr N, von Richter O, Jin L, Nebert DW. 2005. Search for an association between the human CYP1A2 genotype and CYP1A2 enzyme phenotype. Pharmacogenetics and Genomics (In Press)
41. Zhang G, Nebert DW, Chakraborty R, Jin L. 2005. Statistical power of association using the extreme discordant phenotype design. Pharmacogenetics and Genomics. (In Press)
