陈正军
中国科学院蛋白质组学重点实验室 实验室副主任
研究员，研究组长，博士生导师
电话：54921081
E-mail: wchenzj@sunm.shcnc.ac.cn
个人简介：
1983毕业于第二军医大学；1989年获得国家教委青年奖学金赴德国学习；1993在德国乌尔姆大学获得博士学位，并在乌尔姆大学血液肿瘤研究所任博士后；1995年起在德国马普科学院生化所（Max-Planck-Institute of Biochemistry）历任博士后、高级研究人员和课题负责人。2001年3月作为”百人计划”入选者受聘于中科院上海生科院生物化学与细胞生物学研究所，任研究员，博士生导师。曾担任第二军医大学国际合作生物信号传递研究中心客座教授兼副主任，中科院蛋白质组学重点实验室副主任，现任中科院分子细胞生物学重点实验室学术委员会委员。
研究方向：肿瘤学/蛋白质组学
研究工作：
细胞极性与细胞迁移、增殖和肿瘤发生的相关性研究：(1)生长因子受体信号通路调控的细胞极性蛋白酪氨酸磷酸化的生物学功能研究；(2)细胞极性蛋白复合物Par3-Par6-aPKC及其功能相关蛋白在上皮细胞极性中的功能研究；(3)研究Par蛋白复合物及其功能相关蛋白对细胞迁移，增殖及肿瘤发生发展中的影响；(4)研究其他RTKs在上皮细胞极性中的生物学意义。酪氨酸激酶细胞信号通路研究：(1)生长因子受体信号通路在肿瘤发生发展中的作用机理研究；(2)膜结合酪氨酸磷酸化蛋白功能分析及其跨膜信号转导作用机理研究；(3)胰岛素信号通路生物学功能及其在糖尿病发生中作用机理研究。磷酸化蛋白质组学研究：(1)磷酸化蛋白质组学技术方法的研究和发展；(2)肝癌磷酸化蛋白质组学研究；(3)肝癌发生发展过程中的蛋白质差异表达研究。
发表论文：
1. Wang Y, Du D, Fang L, Zhang C, Yang G, Lottspeich F, Ullrich A, Chen Z. Tyrosine Phosphorylated Par3 Regulates Epithelial Tight Junction Assembly Promoted by EGFR Signaling. EMBO J. 2006, 5:5058-5070.
2. Wang Y, Li R, Du D, Zhang C, Yuan H, Zeng R* and Chen Z*. Proteomic Analysis Reveals Novel Molecules Involved in Insulin Signaling Pathway. J Proteome. Res. 2006, 5:846-855 (This paper is cited by JPR as a Featured Article).
3. Lake Jiang Q, Feng X , Zhou W, Knyazev P, Ullrich A, Chen Z. Csk-binding protein(Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation. Oncogene. 2006, 25:5495-5506.
4. Yuan H, Zhang L, Liu A, Zhou H, Wang Y, Zhang H, Wang G, Zeng R, Zhang Y*, Chen Z*. Proteomic profiling of regionalized proteins in rat epididymis indicates consistency between specialized distribution and protein functions. J. Proteome.Res. 2006, 5:299-307.
5. Yao G, Chen W, Luo H, Jiang Q, Xia Z, Zang L, Zuo J, Wei X, Chen Z, Shen X, Dong C, Sun B. Identification of core functional region of murine IL-4 using peptide phage display and molecular modeling. Int Immunol. 2006, 18(1):19-29.
6. Zong X, Eckert C, Yuan H, Wahl-Schott C, Abicht H, Fang L, Li R, Mistrik P, Gerstner A, Much B, Baumann L, Michalakis S, Zeng R, Chen Z*, Biel M*. A Novel Mechanism of Modulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channels by Src Kinase. J. Biol. Chem. 2005, 280(40): 34224-34232.
7. Wang B., Xiao Y., Ding B., Zhang N., Yuan X., Gui L., Qian K., Duan, S. Chen Z., Rao Y. and Geng J. Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell, 2003, 4 (1):19-29.
8. Wu Y, Chen Z, Ullrich A. EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. Biol.Chem. 2003, 384(8):1215-26.
9. Chen Z*, Kharitonenkov A*, Sures I, Wang H, and Ullrich A. A Family of Proteins that Inhibit Signaling through Tyrosine Kinase Receptors. Nature, 1997, 386: 181-186.
10. Wu CJ, Chen Z, Ullrich A, Greene MI, O′Rourke DM. Inhibition of EGFR- mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs). Oncogene. 2000, 19 (35): 3999-4010.
11. Suhad Ali, Chen Z, Jena-Jacques Lebrum, Wolfgang Vogel, Alexei Kharitonenkov, Paul A Kelly and Axel Ullrich: PTP 1D is a positive regulator of the prolactin signal leading to β-casein promoter activation. EMBO J, 1996, 15(1): 135-142.
12. Seiffert M, Cant C, Chen Z, Rappold I, Brugger W, Kanz L, J.Brown E, Ullrich A, Buhring H. Human signal-regulatory protein is expressed on Normal,But not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47. Blood, 1999, 94 (11):3633-3643.
13. Wang H, Lian A, MLerch M, Chen Z, Xie W and Ullrich A. Characterization of PCP-2, a novel receptor protein-tyrosine phosphatase of the MAM domain family. Oncogene. 1996,12:2555-2562.
14. Kharitonenkov A, Schnekenburger J, Chen Z, Knyazev P, Ali S, Zwick E, White M and Ullrich A. Adapter function of Protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate 1 interaction. J. Biol. Chem. 1995, 270(49):29189-29193.
15. Frickhofen N, Chen Z, Young N, et al. Parvovirus B19 as a cause of acquired chronic pure red cell aplasia. Br J Haematol. 1994,87(4): 818-824.
