
徐天乐
中国科学院神经生物学重点实验室 实验室副主任
突触生理学研究组组长
Tianle Xu, Ph.D.
Rm 204, ION Building
Institute of Neuroscience
Chinese Academy of Sciences
Shanghai 200031
China
Email: tlxu@ ion.ac.cn
Phone: 86-21-5492-1752
徐天乐博士现为中科院神经科学研究所研究员、突触生理学研究组组长。1987年毕业于西安第四军医大学,并于 1996 年在该校获医学博士学位。1994-95 年间在日本 Kyushu 大学 Norio Akaike 教授实验室做访问学者,1997年-1999 年获东京生物化学研究基金会资助在 Kyushu 大学生理系从事博士后研究工作, 1999 年后任中国科技大学神经生物和生物物理学系教授、系主任。2003年加入神经科学研究所。徐天乐博士目前研究方向集中在受体药理学和突触生理学。
教育经历
1982年8月-1987年8月 第四军医大学军医专业,获医学学士学位
1990年8月-1993年8月 第四军医大学,获组织与胚胎学硕士学位
1993年8月-1996年8月 第四军医大学,获人体解剖学博士学位
学术经历
1987年8月-1990年8月 第四军医大学组织与胚胎学 助教
1994年9月-1995年9月 日本九州大学生理系 访问学者
1996年8月-1997年7月 第四军医大学人体解剖学 讲师
1997年7月-1999年1月 日本九州大学生理系 博士后
1999年1月-2003年3月 中国科技大学生命科学学院 教授
2003年4月- 中国科学院神经科学研究所突触生理学研究组组长
Publications
Wu, L., Duan, B., Mei, Y., Gao, J., Chen, J., Zhuo, M., Xu, L., Wu, M., and Xu, T. (2004) Characterization of Acid-sensing Ion Channels in Dorsal Horn Neurons of Rat Spinal Cord. J. Biol. Chem. 279(42): 43716-43724 .
Gao, J., Wu, L., Xu, L., and Xu, T. (2004) Properties of the proton-evoked currents and their modulation by Ca(2+) and Zn(2+) in the acutely dissociated hippocampus CA1 neurons. Brain Res. 1017(1-2):197-207
Xiong, W., Wei, H., Xiang, X., Cao, J., Dong, Z., Wang, Y., Xu, T., and Xu L. (2004) The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages. Brain Res. 1005(1-2):187-192
Li, Y., Wu, L., Legendre, P., and Xu, T. (2003) Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons. J Biol Chem. 278(40): 38637-38645
Li, YF., Wu, L., Li, Y., Xu, L., and Xu, T. (2003) Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neurons. J Physiol. 552(Pt 1): 73-87
Nie, D., Zhou, Z., Ang, B., Teng, F., Xu, G., Xiang, T., Wang, C., Zeng, L., Takeda, Y., Xu, T., Ng, Y., Faivre-Sarrailh, C., Popko, B., Ling, E., Schachner, M., Watanabe, K., Pallen, C., Tang, B., and Xiao, Z. (2003) Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization. EMBO J. 22(21): 5666-5678
Li Y, Li YF, Xu TL. Amiloride inhibition of glycinergic miniature IPSCs in mechanically dissociated rat spinal neurons. Neurosci Lett. 2003 Sep 25;349(1):17-20.
Liu, Y., Zhang, G., Hou, X., and Xu, T. (2003) Two types of calcium channels regulating activation of proline-rich tyrosine kinase 2 induced by transient brain ischemia in rat hippocampus. Neurosci Lett. 348(3): 127-130
Li, YF., Li, Y., and Xu, T.. (2003) Inhibition of glycine response by amiloride in rat spinal neurons. Neurosci Lett. 345(3): 173-176
Liu, Y., Hou, X., Zhang, G., and Xu, T. (2003) L-type voltage-gated calcium channel attends regulation of tyrosine phosphorylation of NMDA receptor subunit 2A induced by transient brain ischemia. Brain Res. 972(1-2): 142-148
Wu, Z., and Xu, T. (2003) Taurine-evoked chloride current and its potentiation by intracellular Ca2+ in immature rat hippocampal CA1 neurons. Amino Acids. 24(1-2): 155-161
Zhang, Z., Lu, H., Dong, X., Liu, J., and Xu, T. (2002) Kinetics of etomidate actions on GABA(A) receptors in the rat spinal dorsal horn neurons. Brain Res. 953(1-2): 93-100
Dong, X., and Xu, T. (2002) The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat. Anesth Analg. 95(4): 907-914
Lu, H., and Xu, T. (2002) The general anesthetic pentobarbital slows desensitization and deactivation of the glycine receptor in the rat spinal dorsal horn neurons. J Biol Chem. 277(44): 41369-41378
Gao, J., Zhang, J., and Xu, T. (2002) Modulation of serotonergic projection from dorsal raphe nucleus to basolateral amygdala on sleep-waking cycle of rats. Brain Res. 945(1): 60-70.
Dong, X., and Xu, T. (2002) Radix paeoniae rubra suppression of sodium current in acutely dissociated rat hippocampal CA1 neurons. Brain Res. 940(1-2): 1-9
Wu, L., Li, Y., and Xu, T. (2002) Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons. Neuroreport. 13(7): 977-81
Li, Y., and Xu, T. (2002) State-dependent cross-inhibition between anionic GABA(A) and glycine ionotropic receptors in rat hippocampal CA1 neurons. Neuroreport. 13(2): 223-226
Wu, L., Lu, Y., and Xu, T. (2001) A novel mechanical dissociation technique for studying acutely isolated maturing Drosophila central neurons. J Neurosci Methods. 108(2): 199-206
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