薛勇彪 研究员
职务：遗传与发育生物学研究所所长
E-mail:ybxue@genetics.ac.cn
实验室:http://plantbiol.genetics.ac.cn/the_xue_lab/index_chinese.htm
个人简介
薛勇彪 研究员、课题组长
1983年，兰州大学生物学系动物学专业理学学士；1986年，中国科学院发育生物学研究所理学硕士；1989年，John Innes
Institute 和University of East Anglia博士；1990-1995年，John Innes Centre和University of Oxford博士后。1995-1997年，John
Innes Centre的Sainsbury Laboratory 任Research Scientist。薛勇彪博士系1998年中科院"百人计划"入选者和国家杰出青年科学基金获得者。现任研究所所长、国家973计划"水稻功能基因组学研究"项目首席科学家和《遗传学报》和《遗传》主编，山东农业大学, 北京师范大学和兰州大学兼职或客座教授。
研究方向
1. 金鱼草自交不亲和性的分子机制
自交不亲和性是研究植物花粉识别的模式系统。在以茄科植物为代表的配子体自交不亲和植物中，目前的研究结果表明这些植物的自交不亲和性位点－S-位点编码两类不同的基因分别控制花柱和花粉自交不亲和性的表达。花柱基因编码了一类核酸酶称为S-核酸酶，而花粉基因则编码一类新的F-box基因 （S-locus F-box, SLF），共同构成一个S-单倍型（S-Haplotype）控制自交不亲和性的表达。我们实验室以金鱼草为模式系统克隆了SLF家族的第一个成员－AhSLF-S2，并证明它控制了花粉自交不亲和性的表达,并且它编码的蛋白质通过形成一个SCF（Skp1/
Cullin or CDC53/F-box）复合体与S-核酸酶发生作用。与此同时，我们进一步证明泛素/26S蛋白小体介到的蛋白质降解途径特异性的参与了金鱼草的亲和反应。但是，这两类蛋白质如何相互作用产生特异性花粉识别的机理还不清楚。我们实验室目前的主要工作是利用分子遗传，生物化学和细胞生物学等手段，研究这些蛋白质的作用机理以及S-位点的起源和进化机制。
2. 水稻传粉和受精的分子控制
传粉和受精是种子形成的重要基础。但是我们对于它的分子机理了解还非常不够。目前我们构建了一个由1万多条非冗余cDNA组成的微阵列，并且获得了水稻传粉和受精相关的基因表达谱，克隆了一批候选基因，正在详细鉴定它们的生物学功能。同时，我们与福建农业大学的吴为人和段远霖合作图位克隆控制水稻开花、花器官发育的关键基因。
3. 棉花纤维发育相关基因的克隆和功能鉴定
棉花纤维是胚珠表皮细胞特化的结果。通常30%左右的表皮细胞分化形成棉纤维。目前关于胚珠表皮细胞分化成纤维的分子机理的了解非常有限。利用同源基因克隆的途径，我们分离鉴定了50多个在棉纤维发育早期表达的MYB类转录因子，并发现了一个在纤维发育起始期和伸长期特异表达基因GhMYB109。目前我们正在利用转基因等方法研究该基因在棉纤维发育中的作用机理。
RECENT MAJOR PUBLICATIONS
Xiaoyan Dai , Yunyuan Xu , Qibin Ma , Wenying Xu , Tai Wang , Yongbiao Xue , and Kang Chong *.Overexpression of a R1R2R3
MYB Gene, OsMYB3R-2, Increases Tolerance to Freezing, Drought, and Salt Stress in Transgenic Arabidopsis.
Plant Physiology Preview.Published on February 9, 2007;10.1104/pp.106.094532.
Shao Jun Dai, Tao Tao Chen, Kang Chong, Yong Biao Xue, Si Qi Liu, and Tai Wang.Proteomic identification of differentially
expressed proteins associated with pollen germination and tube growth reveals characteristics of germinated Oryza sativa
pollen.Molecular&Cellular Proteomics. MCP published November 27, 2006,10.1074/mcp.M600146-MCP200.
Xiaolei Zhuang, Jiafu Jiang, Junhua Li, Qibin Ma, Yunyuan Xu, Yongbiao Xue, Zhihong Xu and Kang Chong.Over-expression of
OsAGAP, an ARF-GAP, interferes with auxin influx, vesicle trafficking and root development. The Plant Journal. doi:10.1111/
j.1365-313X.2006.02898.x
Zhaosheng Kong, Meina Li, Wenqiang Yang, Wenying Xu, Yongbiao Xue. A Novel Nuclear-Localized CCCH-Type Zinc Finger
Protein OsDOS, Is Involved in Delaying Leaf Senescence in Rice (Oryza sativa L.) Plant Physiology. 2006; 10.1104/
pp.106.082941[PDF]
Jian Huang, Lan Zhao, Qiuying Yang,Yongbiao Xue. AhSSK1, a novel SKP1-like protein that interacts with the S-locus F-box
protein SLF.The Plant Journal.doi:10.1111/j.1365-313X.2006.
02735.x[Summary] [PDF]
Shaojun Dai, Lei Li, Taotao Chen, Kang Chong, Yongbiao Xue, Tai Wang. Proteomic analyses ofOryza sativamature pollen
reveal novel proteins associatedwith pollen germination and tube growth. Proteomics 2006, DOI 10.1002/pmic.200401351[PDF]
Zhen Wang, Yu Liang1, Chijun Li1, Yunyuan Xu, Lefu Lan, Dazhong Zhao,Changbin Chen, Zhihong Xu1, Yongbiao Xue,
Kang Chong. Microarray analysis of gene expression involved in anther development in rice (Oryza sativa L.).
Plant Molecular Biology (2005) 58:721-737[PDF]
Barry Causier, Rosa Castillo, Junli Zhou,Richard Ingram, Yongbiao Xue,Zsuzsanna Schwarz-Sommer,Brendan Davies. Evolution
in Action: Following Function in Duplicated Floral Homeotic Genes. Current Biology. 2005, 15:1508-1512.[PDF]
Yuling Jiao, Peixin Jia, Xiangfeng Wang, Ning Su , Shuliang Yu , Dongfen Zhang, Ligeng Ma, Qi Feng, Zhaoqing Jin, Lei Li,
Yongbiao Xue, Zhukuan Cheng, Hongyu Zhao, Bin Han and Xing Wang Deng. A Tiling Microarray Expression Analysis of Rice
Chromosome 4 Suggests a Chromosome-Level Regulation of Transcription. Plant Cell, Published online April 29, 2005;10.1105/
tpc.105.031575.
X. Zhuang, Y. Xu, K. Chong, L. Lan, Y. Xue & Z. Xu (2005) OsAGAP, an ARF-GAP from rice, regulates root development mediated
by auxin in Arabidopsis. Plant Cell and Environment. 28: 147-156.[PDF]
Dongfen Zhang, Qiuying Yang, Weidong Bao, Yu Zhang, Bin Han, Yongbiao Xue and Zhukuan Cheng. (2005) Molecular
cytogenetic characterization of the Antirrhinum majus genome. Genetics．169:325-335.[PDF]
Hong Qiao, Fei Wang, Lan Zhao, Junli Zhou, Zhao Lai, Yansheng Zhang, Timothy P.Robbins, and Yongbiao Xue. (2004) TheF-Box
Protein AhSLF-S2 Controls the Pollen Function of S-RNase-Based Self-Incompatibility. Plant Cell.16:2307-2322
Lan, L., Chen, W., Lai, Y., Suo, J., Kong, Z., Li, C., Lu, Y., Zhang, Y., Zhao, X., Zhang, X., Han, B., Cheng, J., Xue, Y. (2004)
Monitoring of gene expression profiles and isolation of candidate genes involved in pollination and fertilization in rice
(Oryza sativa L.) using a 10K cDNA microarray. Plant Mol Biol 54:471-487
Zhang, Y., Huang, Y., Zhang, L., Li, Y., Lu, T., Lu, Y., Feng, Q., Zhang, Q., Cheng, Z., Xue, Y.,Wing, R. A., Han, B. (2004)
Structural features of the rice chromosome 4 centromere. Nucl Acids Res 32:2023-2030
Qiao, H., Wang, H., Zhao, L., Zhou, J., Huang, J., Zhang, Y., Xue, Y. (2004) The F-box protein AhSLF-S2 physically interacts with
S-RNases that may be inhibited by the ubiquitin/26S proteasome pathway of protein degradation during compatible pollination in
Antirrhinum. Plant Cell 16:582-295
Zhou, J., Wang, F., Ma, W., Zhang, Y., Han, B., Xue, Y. (2003) Structural and transcriptional analysis of S locus F-box (SLF)
genes in Antirrhinum. Sex. Plant Reprod. 16:165-177
Suo, J., Liang, X., Pu, L., Zhang, Y., Xue, Y. (2003) Identification of GhMYB109 encoding a R2R3 MYB transcription factor that
expressed specifically in fiber initials and elongating fibers in cotton. BBA 1630:25-34
Xue, Y., Li, J., Xu, Z. (2003) Recent highlights of the China Rice Functional Genomics Program.rends Genet. 19:390-394
Liang, L., Huang, J., Xue, Y. (2003) Identification and evolutionary analysis of a relic S-RNasein Antirrhinum. Sex. Plant Reprod.
16:17-22
Han, B. and Xue, Y. (2003) Genome-wide intraspecific DNA-sequence variations in rice. Curr. Opin. Plant Biol. 6:134-138
Liang, L., Lai, Z., Ma, W., Zhang, Y. and Xue, Y. (2002) AhSL28, a senescence-and phosphosphate starvation-induced S-like
RNase gene in Antirrhinum. BBA 1579:64-71
Feng, Q., Zhang, Y., Hao, P. et al. (2002) Sequence and analysis of rice chromosome 4.Nature 420:316-320
Zhao, Q., Zhang, Y., Cheng, Z. et al. (2002) A fine physical map of the rice chromosome 4. Genome Res. 12:817-823
Lai, Z., Ma, W., Han, B., Liang, L., Zhang, Y., Hong, G., Xue, Y. (2002) An F-box gene linked to the self-incompatibility (S) locus
of Antirrhinum is expressed specifically in pollen and tapetum. Plant Mol. Biol. 50:29-41
Xu, H., Weterings, K., Vriezen, W., Feron, R., Xue, Y., Derksen, J., Mariani, C. (2002) Isolation and characterization of
male-germ-cell transcripts in Nicotiana tabacum. Sex. Plant Reprod. 14:339-346.
Chen, W., Tang, D., Suo, J., Zhang, Y., Xue, Y. (2001) Expressional profiling of genes related to pollination and fertilization in
rice. C. R. Acad. Sci. Ser.III, 324:1111-1116.
