戴建武 研究员
E-mail:jwdai@genetics.ac.cn
个人简介
戴建武， 博士， 研究员， 博士生导师。
本科毕业于武汉大学生物系细胞生物学专业。硕士毕业于北京医科大学生物物理学专业。1993年留学美国，从事细胞生物学和生物工程学研究。后在杜克大学（Duke University）获博士学位。毕业后在哈佛大学医学院做博士后，主要从事小鼠基因敲除及干细胞生研究。随后在企业从事组织工程研究及产品研发。在包括世界顶尖期刊CELL 在内的期刊上发表学术论文近50篇。受过良好的多学科交叉训练，具有丰富的科研经历和企业管理经验。2003年回国在中国科学院遗传与发育生物学研究所工作，是中国科学院"百人计划"入选者；国家杰出青年基金（生物材料领域）获得者；国家重大科学研究计划《调控干细胞自我更新能力的分子网络研究》项目首席科学家。研究方向是生物材料，组织工程与创伤修复。
再生医学是一门新兴的多学科交叉学科。其中，发育生物学，细胞生物学，分子生物学，材料科学，工程学，以及临床医学占有重要位置。
研究方向
组织工程，组织再生与创伤修复。
1．干细胞自我更新和定向分化的研究
通过不同的实验体系，研究干细胞自我更新和定向分化的调控机理。
2．组织再生因子基因工程
通过基因工程方法，利用不同的表达体系，制备多种组织再生因子。
3．功能生物材料的研究
制备引导不同组织再生的生物材料，建立有效的生物材料活化方法。
实验室诚邀各类人才及合作伙伴
实验室坚持以人为本的发展方向，强调团队协作精神，营造友爱互助的工作环境。目标是建立一流的再生医学研究实验室，进行高质量的科学研究，培养再生医学人才。诚邀天下英才加盟，特别是细胞生物学、神经生物学、发育生物学、生物力学、材料科学、以及临床医学等方面的人才。同时，我们将本着精诚合作的态度，共赢多赢的合作目标，愿与国内外相关单位及个人建立合作关系，共同开展再生医学领域的研究。
回国后发表的主要文章
Sun, W., Lin, H., Chen, B., Zhao, W., Zhao, Y., and Dai J.* (2007) Promotion of peripheral nerves growth by collagen scaffolds
loaded with collagen-targeting human NGF-β . Journal of Biomedical Materials Research, in press
Ma, S., Lin, H., Miao, Y., Liu, X., Wang, B., and Dai J.* (2007) The effect of three-dimensional collagen matrix on in vitro
cumulus-free oocyte maturation. Biomaterials, in press
Zhao, W., Chen, B., Lin, H., Sun, W., Zhao, Y., Wang, B., Zhao, Y., and Dai J.* (2007) Vascularization and cellularization of
collagen scaffolds incorporated with human basic fibroblast growth factors. Journal of Biomedical Materials Research, in press
Chen, B., Lin, H., Wang, J., Zhao, Y., Wang, B., Zhao, W., Sun, W. and Dai J.* (2007) Homogeneous osteogenesis and bone
regeneration by collagen matrix loading with bone morphogenetic protein-2. Biomaterials 28(6):1027-35.
Chen, B., Lin, H., Zhao, Y., Wang, B., Zhao, Y., Liu, Y., Liu, Z. and Dai J.*(2007) Activation of collagen matrix by genetically
engineered human bone morphogenetic protein-2. Journal of Biomedical Materials Research 80(2):428-34.
Lin, H., Chen, B., Sun, W., Zhao, W., Zhao, Y. and Dai J.* (2006) Platelet-derived growth factor (PDGF) promotes cellularization
and vascularization of collagen scaffolds. Biomaterials 27(33):5708-14.
Ding, W., Lin, L., Chen, B. and Dai J.* (2006) L1 elements, processed pseudogenes and retrogenes in mammalian genomes.
IUBMB Life 58(12):1-9.
Suo, G., Chen, B., Zhang, J., Gao, Y., Wang, X., He, Z. and Dai J.* (2006) Expression of active hBMP2 in transgenic tobacco
plants. Plant Cell Reports 25(12):1316-24.
Lin, H., Chen, B., Wang, B. and Dai J.* (2006) Novel nerve guidance material prepared from bovine collagen.
Journal of Biomedical Materials Research 79(3):591-8.
He, Z., Duan, Z., Liang, W., Chen, F., Yao, W., Liang, H., Sun, Z. and Dai J.* (2006) Mannose selection system used for
cucumber transformation. Plant Cell Reports 25(9):953-8.
Wang, B., Zhao, Y., Lin, H., Chen, B., Zhang, J., Wang, X., Zhao, W. and Dai J.* (2006) Phenotypical analysis of adult rat olfactory ensheathing cells on 3-D collagen scaffolds. Neuroscience Letters 401(1-2):65-70.
Zhang, J., Wang, X., Han, J., Chen, B., Wang, B., Suo, G. and Dai J.* (2006) NANOGP8 is a retrogene expressed in cancers.
FEBS Journal 273(8): 1723-30.
Zhang, J.,Wang, X., Zhao, Y., Chen, B., Suo, G. and Dai J.* (2006) Neoplastic transformation of cultured human fibroblasts after
long-term serum starvation. Cancer Letters 243: 101-108.
Suo, G., Chen, B., Hang, J., Duan, Z., He, Z., Yao, W., Yue, C.and Dai J.* (2006) Effects of codon-modification on human BMP2
gene expression in tobacco plants. Plant Cell Reports 25(7):689-97.
Gao, Y., Suo, G., Han, J., He, Z., Yao, W. and Dai J.* (2006). Expression of human BMP-2 gene in different tissues of tobacco
plants. Acta Genetica Sinica 33(1):56-62.
史新立，谭芳奕，王召旭，奚廷斐，解慧琪，杨志明， 戴建武*. (2006). 疯牛病病原体研究及动物源性医疗器械产品安全性思考. 中国修复重建外科杂志 20（11）：1138-1144.
Ding, W., Zou, H., Dai J.* and Duan, Z*. (2005) Combining restriction digestion and touchdown PCR permits detection of trace
isoforms of the histamine H3 receptor. Biotechniques 39: 841-845.
Zhang, J., Wang, X., Chen, B., Suo, G., Zhao, Y., Duan, Z.and Dai J.* (2005) Expression of nanog gene promotes NIH3T3 cell
proliferation. Biochemical and Biophysical Research Communications 338: 1098-1102.
Suo, G., Han, J., Wang, X., Zhang, J., Zhao, Y., Zhao, Y. and Dai J.* (2005) Oct4 pseudogenes are transcribed in cancers.
Biochemical and Biophysical Research Communications 337: 1047-1051.
回国前发表的部分文章
Dai J., et al. (2002) A novel signaling complex for stem cell differentiation. In vitro Cellular and Developmental Biology
38:198-204.
Dai J., and Michael P. Sheetz. (1999). Membrane tether fromation from blebbing cells. Biophysical J. 77. 3363-3370.
Dai J., H. Ping Ting-Beall, Michael P. Sheetz, Robert M. Hochmuth, and Margaret A. Titus. (1999). Myosin I contributes to the
generation of resting cortical tension. Biophysical J. 77, 1168-1176.
Dai J., Michael. P. Sheetz, Xiaodong, Wan, and Catherine E. Morris. (1998) Membrane tension in swelling and shrinking
molluscan neurons. J. Neurosci. 18:6681-6692.
Dai J., H. Ping Ting-Beall and Michael P. Sheetz. (1997) The secretion-coupled endocytosis correlates with membrane tension
changes in RBL 2H3 cells. J. Gen. Physiol. 110: 1-10.
Dai J., and Michael P. Sheetz (1995) Axon membrane flows from the growth cone to the cell body. Cell 83: 693-701.
Dai J., and Michael P. Sheetz (1995). Mechanical Properties of Neuronal Growth Cone Membranes Studied by Tether Formation
with Laser Optical Tweezers. Biophysical J. 68: 988-996.
Dai J., Qun Dong, Yaxian Su, and Kechun Lin (1992) Effect of ConA-receptor interaction on the structure of cell membranes.
Cell Research 2: 129-138.
