张健存 博士 中国科学院广州生物医药与健康研究院研究员
研究兴趣
我们的研究应用现代化学技术致力于研究和开发人类和社会需求的创新药物。研究领域包括：
研究和开发新型特别是以核苷类小分子为基础的化学药物;
合理设计和合成及天然产物的合成和修饰小分子抗癌药物
寡聚核苷酸衍生物的设计和合成
药物合成工艺及新有机合成方法的研究。
联系方式：zhang_jiancun@gibh.ac.cn
教育
1985-1990 美国University of Pittsburgh有机化学博士
1984-1985 中山大学英语培训中心英语培训
1980-1984 复旦大学学士
专业工作经历
2005- 至今 中国科学院广州生物医药与健康研究院合成与天然药物中心，研究员
2000-2004 上海交通大学药学院，教授
2002-2004 清华源兴生物医药与科技公司，首席科学官
1992-2001 Gilead Sciences公司，资深科学家
1990-1992 Duke大学博士后
论文发表选录
J Zhang and etc “Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds” US patent, 10/423,496, April 25th, 2003
J． Zhang and etc. “Method and compositions for identifying anti-HIV therapeutic compounds”US patent, 10/740,694, Dec. 22, 2003
J. Zhang and M. Matteucci “Improved Method for Oligonucleotide Analog Synthesis” US Patent, 5, 646, 269, July 8th, 1997.
J. Zhang and etc. “Method for manufacturing silver containing textiles” Chinese patent pplication number, 2003101003085
J. Zhang and etc. “Methods for treatment of liver disease”, Chinese application number, 03140466.9
J. Zhang and M. Matteucci “a Mild Method for the Synthesis of 3’-Thioformacetal Dinucleotide: the Development of Diphenylphosphinate Acetal as a Glycosylating agents” Tetrahedron Letters, 1995, 36, 8375.
J. Zhang and M. Matteucci “Synthesis of a PH-mediated N-Acylsulfamide Linked Dinucleotide and Its Incorporation into an Oligonucleotide” Bioorganic and Medicinal Chemistry Letters, 1999, 9, 2213
M.C. Pirrung, J. Zhang and A. T. McPhail “Dipolar Cycloadditions of Cyclic Rhodium Carbenoids to Aromatic heterocycles” J. Org. Chem., 1991, 56, 6259
D. P. Curran, W. Shen, J. Zhang and T. A. Heffner “Asymmetric Radical Addition, Cycloaddition and Annulation reactions with Oppolzer’s Camphor Sultam” J. Am. Chem. Soc., 1990, 112, 6738
D. P. Curran and J. Zhang “Nucleophilic Addition and reduction of 5-Acyl and 5-Formyl-isoxazolines. A General preparation of syn and anti dihydroxylcarbonyls” J. Chem. Soc., Perkin Trans. 1, 1991, 2613
