胡文辉 博士 中国科学院广州生物医药与健康研究院研究员
研究兴趣
以抗糖尿病药物的研发为中心，主要从事小分子药物的设计与合成，新药物靶标的验证，药物合成方法学的研究等。
目前的主要研究领域包括：
新型DPP-IV抑制剂的设计与合成；
雌激素相关受体（ERR）调节剂的设计与合成；
类药小分子探针库的构建。
联系方式：hu_wenhui@gibh.ac.cn
教育
1999 - 2002 博士学位 药物化学专业 中国医学科学院和北京协和医科大学药物研究所
1996 - 1999 硕士学位 有机化学 山西大学化学系
1992 - 1996 学士学位 化学专业 山西大学化学系
专业工作经历
2006.11 - 副研究员，合成与天然药物中心，中国科学院广州生物医药与健康研究院
2002.12 – 2006.10 博士后，药物发现与化学生物学中心，美国西北大学医学院。
论文发表选录
Wenhui Hu, Hantamalala Ralay Ranaivo, Saktimayee M. Roy, Heather A. Behanna, Laura K. Wing, Lenka Munoz, Ling Guo, Linda J. Van Eldik and D. Martin Watterson. Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits. Bioorganic & Medicinal Chemistry Letters. 2007, 17(2): 414-418.
Hantamalala Ralay Ranaivo, Jeffrey M. Craft, Wenhui Hu, Ling Guo, Laura K. Wing, Linda J. Van Eldik and D. Martin Watterson. Glia as a therapeutic target: attenuation of human A? induced neuroinflammation and hippocampal deficits by oral administration of a selective inhibitor of glial activation.Journal of Neuroscience. 2006, 26(2): 662-670.
Wenhui Hu, Hantamalala Ralay Ranaivo, Jeffrey M. Craft, Linda J. Van Eldik, and D. Martin Watterson. Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer’s disease-related mouse model. Current Alzheimer Research. 2005, 2, 197-205.
Lenka Munoz, Hantamalala Ralay Ranaivo, Saktimayee M. Roy, Wenhui Hu, Jeffrey M. Craft, Laurie K. McNamara, Linda J. Van Eldik and D. Martin Watterson. A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. Glia. Submitted.
Jeffrey M. Craft, Linda J. Van Eldik, Magdalena Zasadzki, Wenhui Hu and D. Martin Watterson. Aminopyridazines attenuate hippocampus dependent behavioral deficits induced by human A in a murine model of neuroinflammation. The Journal of Molecular Neuroscience. 2004, 24:115-122.
Wenhui Hu, Zongru Guo, Xiang Yi, Changbin Guo, Fengming Chu and Guifang Cheng. Discovery of 2-Phenyl-3-sulfonylphenyl-indole derivatives as a new class of selective COX-2 inhibitors. Bioorganic & Medicinal Chemistry. 2003, 11(24): 5539-44.
Wenhui Hu, Zongru Guo, Fengming Chu, Aiping Bai, Xiang Yi, Guifang Cheng, Jing Li. Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: a new series of selective COX-2 inhibitors. Bioorganic & Medicinal Chemistry. 2003, 11(7), 1153-1160.
Wen Hui Hu, Zong Ru Guo, Ai Ping Bai, Zhi Bin Xu. A convenient synthesis of the substituted 2,3-diaryl-indole – the potent selective COX-2 inhibitors. Chinese Chemical Letters. 2002, 13(4): 296-298.
Ai Ping Bai, Zong Ru Guo, Wen Hui Hu, Fang Shen, Gui Fang Cheng. Design, synthesis and in vitro evaluation of a new class of novel cyclooxygenase-2 inhibitors: 3, 4-diaryl-3-pyrrolin-2-ones. Chinese Chemical Letters. 2001, 12(9): 775-778.
