陈新 副教授 植物生理学与生物化学国家重点实验室
陈新 副教授
浙江大学 生命科学学院
电话: +86 571 88206612 - 15
电子信箱: xinchen @ zju.edu.cn
个人经历
2005. -: 浙江大学生命科学学院，副教授
2004-2005：蓝图计划亚洲研究院（The blueprint initiative, Asia），部门经理（Manager, High-throughput Biology）
2002-2004：新加坡国立大学，教学助理（全职教师，教学助理为国立大学的初级教职）
2000-2004：新加坡国立大学，计算科学系，博士学位(其中2002-2004为part-time)
1996-2000：上海交通大学，生物技术和计算机科学系，双学士学位
主要研究领域
计算机辅助药物设计
生物信息的表示和数据挖掘
统计（机器）学习方法的生物学应用
代谢-调控网络分析
近期论文
*: Corresponding author(s).
Traditional Chinese Medicine Information Database and Applications in Mechanism Study and Recipe Validation. X.Chen, H.Zhou, Y.B.Liu, J.F.Wang, H.Li, C.Y.Ung, L.Y.Han and Y.Z.Chen*. British Journal of Pharmacology. 2006 (Accepted)
Does Drug-Target Have a Likeness? H.Xu, Y.Fang, L.X.Yao, Y.Z.Chen and X.Chen*. Methods of Information in Medicine. 2006 (Accepted)
Cytokinin Represses Phosphate-Starvation Response through Increasing of Intracellular Pi Level. X.M.Wang, K.K.Yi, Y.Tao, F.Wang, Z.C.Wu, D.A.Jiang, X.Chen*, L.H.Zhu and P.Wu*. Plant Cell and Enviroment. 2006 (Accepted)
PharmGED: Pharmacogenetic Effect Database. B.Xie, C.J.Zheng, L.Y.Han, S.Ong, J.Cui, H.L.Zhang, L.Jiang, X.Chen and Y.Z.Chen*. Clin. Pharmacol. Ther. 2006 (Accepted)
Computer Prediction of Cardiovascular and Hematological Agents by Statistical Learning Methods. X.Chen, H.Li, C.W.Yap, C.Y.Ung, L.Jiang, Z.W.Cao, Y.X.Li and Y.Z.Chen*. Cardiovasc. Hematol. Agents Med. Chem. 2006 (Accepted)
Internet Resources Related to Drug Action and Human Response: A Review. L.X.Yao, Z.C.Wu, Z.L.Ji, Y.Z.Chen and X. Chen*. Applied Bioinformatics. 2006 (Accepted)
PROFEAT: a web server for computing structural and physicochemical features of proteins and peptides from amino acid sequence. Z.R.Li, H.H.Lin, L.Y.Han, L.Jiang, X.Chen and Y.Z.Chen*. Nucleic Acids Research. 34:w32-w37 (2006).
Information of ADME-associated proteins and potential application for pharmacogenetic prediction of drug responses. C.J.Zheng, L.Y.Han, X.Chen, Z.W.Cao, J.Cui, H.H.Lin, H.L.Zhang, H.Li and Y.Z.Chen*. Curr. Pharmacogenomics. 4(2):87-103 (2006).
Prediction of Functional Class of the SARS Coronavirus Proteins by a Statistical Learning Method. C.Z.Cai, L.Y.Han, X.Chen, Z.W.Cao, Y.Z.Chen*. J. Proteome Res. 4 (5): 1855-1862 (2005).
TCM-ID: Traditional Chinese Medicine information database. J.F.Wang, H.Zhou, L.Y.Han, Z.W.Cao, X.Chen and Y.Z.Chen*. Clin. Pharmacol. Ther. 78(1):92-93 (2005).
Computer prediction of drug resistance mutations in proteins. Z.W.Cao, L.Y.Han, C.J.Zheng, Z.L.Ji, X.Chen, H.H.Lin and Y.Z.Chen*. Drug Discov. Today. 10(7):521-529 (2005).
The Biomolecular Interaction Network Database and related tools 2005 update. C.Alfarano, …, C.Xin, ... C.W. Hogue*. (75 authors in alphabetical order). Nucleic Acids Res. 33:418-424. (2005).
Effect of Molecular Descriptor Feature Selection in Support Vector Machine Classification of Pharmacokinetic and Toxicological Properties of Chemical Agents. Y.Xue, Z.R.Li, C.W.Yap, L.Z.Sun, X.Chen, Y.Z.Chen*. J. Chem. Inf. Comput. Sci., 44, 1630-1638. (2004).
Drug ADME-Associated Protein Database as a Resource for Facilitating Pharmacogenomics Research. C.J.Zheng, L.Z.Sun, L.Y.Han, Z.L.Ji, X.Chen, Y.Z.Chen*. Drug Development Research, 62:134-142. (2004).
SVM-Prot: Web-Based Support Vector Machine Software for Functional Classification of a Protein from Its Primary Sequence.C.Z. Cai, L.Y. Han, Z.L. Ji, X.Chen and Y.Z. Chen*. Nucleic. Acids. Res. 31(13), 3692-3697. (2003).
Can an In-Silico Drug-Target Search Method be Used to Probe Potential Mechanisms of Medicinal Plant Ingredients? X.Chen, C.Y.Ung and Y.Z.Chen*. Nat. Prod. Rep., 20, 432-444. (2003).
Correlation between Normal Modes in The 20-200cm-1 Frequency Range and Localized Torsion Motions Related to Certain Collective Motions in Proteins. Z.W.Cao, X.Chen and Y.Z.Chen*. J. Mol. Graph. Mod., 21, 309-319. (2003).
Internet Resources for Proteins Associated with Drug Therapeutic Effects, Adverse Reactions, and ADME. Z.L.Ji, L.Z.Sun, X.Chen, C.J.Zheng, L.X.Yao, L.Y.Han, Z.W.Cao, J.F.Wang, W.K.Yeo, C.Z.Cai and Y.Z.Chen*. Drug Discovery Today, 8(12), 526-529. (2003).
Drug Adverse Reaction Target Database (DART): Proteins Related to Adverse Drug Reactions. Z.L.Ji, L.Y.Han, C.W.Yap, L.Z.Sun, X.Chen and Y.Z.Chen*. Drug Saf., 26(10), 685-690. (2003).
KDBI:Kinetic Data of Bio-molecular Interactions Database. Z.L.Ji, X.Chen, C.J.Zheng, L.Y.Han , W.K.Yeo, P.C.Chung, H.S.Puy, Y.T.Tay,,A. Muhammad and Y.Z.Chen*. Nucleic. Acids. Res., 31(1), 255-257. (2003).
Absorption, Distribution, Metabolism, and Excretion-Associated Protein Database. L.Z.Sun, Z.L.Ji, X.Chen, J.F.Wang and Y.Z.Chen*. Clin. Pharmacol. Ther., 71, 405. (2002).
CLiBE: A Database of Computed Ligand Binding Energy for Ligand-Receptor Complexes. X.Chen, Z.L.Ji and Y.Z.Chen*. Computers and Chemistry, 26(6), 661-666. (2002).
ADME-AP: A database of ADME associated proteins. L.Z.Sun, Z.L.Ji, X.Chen, J.F.Wang and Y.Z.Chen*. Bioinformatics, 18, 1699-1700. (2002).
TTD: Therapeutic Target Database. X.Chen, Z.L.Ji and Y.Z.Chen*. Nucleic. Acids. Res., 30, 412-415. (2002).
