金英花 药学学博士；教授、博士生导师
金英花教授，1965年出生。1988年于吉林大学分子生物学系获生物化学专业获理学学士学位；1996年于国立首尔大学药学院获药学硕士学位；2000年于首尔大学药学院获药学博士学位。2000-2004年于首尔大学综合药物研究所从事博士后及高级研究员工作； 2005年作为学术带头人受聘于吉林大学分子酶学工程教育部重点实验室。
研究方向：
• 细胞周期的调控机制；
• 细胞凋亡通路的调控机制；
• 细胞信号转导机制；
• 转移癌细胞抵抗细胞凋亡的分子机制及抗癌药物的研发;
• 抗癌药物的研发。
Publication Selected
1. Ying Hua Jin, Kye Jin Yoo, You Hui Lee, and Seung Ki Lee. Caspase 3-mediated Cleavage of p21WAF1/CIP1 Associated with the Cyclin A-Cdk2 Complex is a Prerequisite for Apoptosis in SK-HEP-1 Cells. J Biol Chem.2000, 275, 30256-30263;
2. Ying Hua Jin, JoonSeoK Choi , Jeong Hill Park, and Seung Ki Lee. Panaxadiol, a new Diol-Type Ginseng Saponin, Induces Cell Cycle Arrest at S phase by Selective Inhibition of Cyclin A-Associated Cdk2 Activity. Carcinogenesis 2003, 24, 1767-1772.
3. Ying Hua Jin, Hyungshin Yim, Jeong Hill Park, and Seung Ki Lee. Cdk2 activity is associated with depolarization of mitochondria membrane potential during apoptosis. Biochem Biophys Res Commun. 2003, 305, 974-980
4. Hyungshin Yim, Ying Hua Jin, Byoung Duck Park, Hye Jin Choi, and Seung Ki Lee Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p46 truncated Cdc6 and apoptosis. Mol Biol Cell 2003, 14, 4250-4259
5. Joon-Seok Choi, Soona Shin, Ying Hua Jin and Seung ki Lee Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis, Apoptosis, 2007, 12, 1229-1241
6. Hyungshin Yim, In Sun Hwang, Joon Seok Choi, Kwang-Hoon Chun, Ying Hua Jin, and Seung Ki Lee Cleavage of Cdc6 by Caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells J. Cell .Biol. 2006, 174, 77-88
7. Xiaoyu Xue, Haitao Yang, Wei Shen, Qi Zhao, Jun Li，Kailin Yang, Cheng Chen, Yinghua Jin, Mark Bartlam，and Zihe Rao Production of Authentic SARS-CoV M pro with Enhanced Activity: Application as a Novel Tag-cleavage Endopeptidase for Protein Overproduction J. Mol. Biol. (2007) 366, 965–975
8. HE Kan, CHEN Yue, LI Jing-Hua, ZHAN Zhuo, JIN Ying-Hua, CyclinA-Cdk2 phosphorylates BH3 only protein BAD in vitro and in vivo. Chemical Research in Chinese Universities 2007, 23, 567-570
