陈育新 博士 教授
Email:chen.yuxin@jlu.edu.cn
tel:0431-88498092
学术经历:
陈育新教授，1972年出生。1995年于东北师范大学生物系获生物学学士学位；1998年于吉林大学酶工程国家重点实验室获生物化学硕士学位；1999年于加拿大阿尔伯塔大学医学院生物化学系师从加拿大皇家科学院 院士Robert S. Hodges博士开始抗菌肽的研究工作，2005年获生物化学博士学位；2005-2007年于美国科罗拉多大学健康科学中心生物化学与分子遗传学系从事博士后工作； 2007年作为学术带头人受聘于吉林大学分子酶学工程教育部重点实验室。
研究方向：
• 肽类与蛋白类药物的从头设计与应用
• 生物活性短肽的酶法/化学法制备与活性研究
• 高效液相色谱在蛋白质工程与酶学研究上的应用
代表性研究成果:
• 首次提出关于抗菌肽抗菌机理的“细胞膜区分机理”；
• 高活性、低毒性的抗菌肽的从头设计与功能研究，已获得美国专利与国际专利。
主要获奖情况:
• 1999 年，获得加拿大阿尔伯塔大学 “University of Alberta Ph.D. Scholarship”
• 2004 年，获得加拿大阿尔伯塔大学 “J. Gordin Kaplan Graduate Student Award”
专利:
• 拥有美国专利一项: Antimicrobial peptides and methods of use
专利号: 60/636,220
发明人: Hodges, R. S., Chen, Y., Vasil, M., Hancock, R. E. W. and Farmer, S.
• 拥有国际专利一项: Antimicrobial peptides and methods of use
国际专利号(PCT): WO 2006/065977 A2
发明人: Hodges, R. S., Chen, Y., Vasil, M., Hancock, R. E. W. and Farmer, S.
近5年发表论文（2002-2007）:
1. Chen, Y., Guarnieri, M. T., Vasil, A. I., Vasil, M. L., Mant, C. T. and Hodges, R. S. The role of peptide hydrophobicity in the mechanism of action of α-helical antimicrobial peptides, Antimicrob. Agents Chemother., 2007, 51，1398-1406
2. Mant, C. T., Chen, Y., Yan, Z., Popa, T. V., Kovacs, J. M., Mills, J. B., Tripet, B. P. and Hodges, R. S. HPLC analysis and purification of peptides, In “Peptide Characterization and Application” Methods in Mol. Biol. Series (Ed. G. B. Fields) Humana Press 2007, in press
3. Chen, Y., Mant, C. T. and Hodges, R. S. Preparative reversed-phase high-performance liquid chromatography collection efficiency for an antimicrobial peptide on columns of varying diameters (1mm to 9.4mm I.D.) J. Chromatogr. 2007, 1140, 112-120
4. Lewis, R. N. A. H., Liu, F., Krivanek, R., Rybar, P., Hianik, T., Flach, C. R., Mendelsohm, R., Chen, Y., Mant, C. T., Hodges, R. S. and McElhaney, R. N. Studies of the minimum hydrophobicity of α-helical peptides required to maintain a stable transmembrane association with phospholipid bilayer membranes Biochemistry 2007, 46, 1042-1054
5. Chen, Y., Vasil, A. I., Rehaume, L., Mant, C. T., Burns, J. L., Vasil, M. L., Hancock, R. E. W. and Hodges, R. S. Comparison of biophysical and biological properties of α-helical enantiomeric antimicrobial peptides, Chem. Biol. Drug Des., 2006, 67, 162-173
6. Chen, Y., Mant, C. T., Farmer, S., Vasil, M., Hancock, R. E. W. and Hodges, R. S. Rational Design of α-Helical Antimicrobial Peptides with Enhanced Activities and Specificity/Therapeutic Index, J. Biol. Chem., 2005, 280, 12316-12329
7. Hodges R. S., Chen, Y., Ziemba B., and Guarnieri M. The de novo design of antimicrobial peptides with broad spectrum activity and specificity between bacterial and human cell membranes, Biopolymers, 2005, 80, 544-544
8. Chen, Y., Mehok, A. R., Mant, C. T. and Hodges, R. S. Optimum concentration of trifluoroactic acid (TFA) for reversed-phase chromatography of peptides revisited J. Chromatogr. 2004, 1043, 9-18
9. Chen, Y., Mant, C. T. and Hodges, R. S. Selectivity differences in the separation of amphipathic α-helical peptides during reversed-phase chromatography at pH 2.0 and pH 7.0: Effects of different packings, mobile phase conditions and temperature J. Chromatogr. 2004, 1043, 99-111
10. Hodges, R. S., Chen, Y., Kopecky, E. and Mant, C. T. Monitoring the Hydrophilicity/Hydrophobicity of Amino Acid Side-chains in the Non-polar and Polar Faces of Amphipathic α-Helices by Reversed-Phase and Hydrophilic Interaction/Cation-Exchange Chromatography J. Chromatogr. 2004, 1053, 161-172
11. Popa, T. V., Mant, C. T., Chen, Y. and Hodges, R. S. Capillary zone electrophoresis of α-helical diastereomeric peptide pairs with anionic ion-pairing reagents J. Chromatogr. 2004, 1043, 113-122
12. Chen, Y., Mant, C. T. and Hodges, R. S. Temperature selectivity effects in reversed-phase chromatography due to conformation differences between helical and non-helical peptides J. Chromatogr. 2003, 1010, 45-61
13. Mant, C. T. Chen, Y. and Hodges, R. S. Temperature profiling of polypeptides in reversed-phase chromatography: I. Monitoring of dimerization and unfolding of amphipathic α-helical peptides J. Chromatogr. 2003, 1009, 29-43
14. Hartmann E., Chen, Y., Mant, C. T., Jungbauer, A. and Hodges, R. S. Comparison of reversed-phase chromatography and hydrophilic interaction/cation-exchange chromatography for the separation of amphipathic α-helical peptides with L- and D-amino acid substitutions in the hydrophilic face J. Chromatogr. 2003, 1009, 61-71
15. Chen, Y. and Hodges, R. S. Effect of secondary structure on selectivity of reversed-phase chromatography for peptide separations at varying temperatures. Biopolymers 2003，71，334-334
16. Chen, Y., Mant, C. T. and Hodges, R. S. Determination of stereochemistry stability coefficients of amino acid side-chains in an amphipathic α-helix J. Peptide Res. 2002, 59, 18-33
