
学术带头人:杨荣阁研究员
杨荣阁 医学博士,研究员,中科院武汉病毒研究所艾滋病学科组长。
1986年7月获中国医科大学公共卫生学专业医学学士学位,1999年3月获日本山梨医科大学微生物学专业医学博士学位。1994年4月至2005年6月在日本山梨医科大学、日本国立感染症研究所艾滋病中心从事HIV/AIDS相关研究工作。2005年6月回国到中科院武汉病毒研究所工作,中国科学院“百人计划”入选者,武汉病毒研究所学术、学位委员会委员。兼任《中国病毒学》副主编、日本岩手医科大学客座讲师、湖北省微生物学会第十届理事会理事。
长期从事HIV/AIDS分子流行病学及分子病毒学基础研究,对中国艾滋病流行源头地区云南省的HIV基因变异及重组有一定的研究,建立了一套新的分子流行病学分析方法,揭示了部分中国HIV流行重组株形成机理,阐明了部分中国境内HIV/AIDS流行规律,成功地克隆了感染性HIV流行性病毒株等,先后发表一系列相关论文及申请了相关专利。目前承担中科院“百人计划”、国家“863”、“973”等科研课题。
代表性学术论文
1. Saksena N, Wang B, Steain M, Yang R, Zhang L. (2005) Snapshot of HIV pathogenesis in China. Cell Res. 2005. Nov-Dec; 15 (11-12): 953-961.
2. Li XJ, Kusagawa S, Xia X, Yang C, Wang Q, Yokota Y, Hoshina Y, Onogi T, Nohtomi K, Imamura Y, Shiino T, Yang R, Yamamoto N, Ben K, Takebe Y. (2005) Molecular epidemiology of the heterosexual HIV-1 transmission in Kunming, Yunnan Province of China suggests origin from the local IDU epidemic. AIDS Res Hum Retroviruses. 2005 Nov; 21(11): 977-80.
3. Yamamoto N, Yang R, Yoshinaka Y, Amari S, Nakano T, Cinatl J, Rabenau H, Doerr HW, Hunsmann G, Otaka A, Tamamura H, Fujii N, Yamamoto N. (2004) HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus. Biochem Biophys Res Commun. 2004 Jun 4; 318 (3): 719-25.
4. Yang R, Kusagawa S, Zhang C, Xia X, Ben K, Takebe Y. (2003) Identification and characterization of a new class of human immunodeficiency virus type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China. J Virol. 2003 Jan; 77 (1): 685-95.
5. Yang R, Xia X, Kusagawa S, Zhang C, Ben K, Takebe Y. (2002) On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China. AIDS. 2002 Jul 5; 16 (10): 1401-7.
6. Kusagawa S, Sato H, Tomita Y, Tatsumi M, Kato K, Motomura K, Yang R, Takebe Y. (2002) Isolation and characterization of replication-competent molecular DNA clones of HIV type 1 CRF01_AE with different coreceptor usages. AIDS Res Hum Retroviruses. 2002 Jan 20; 18 (2): 115-22.
7. Zhang C, Yang R, Xia X, Qin S, Dai J, Zhang Z, Peng Z, Wei T, Liu H, Pu D, Luo J, Takebe Y, Ben K. (2002) High prevalence of HIV-1 and hepatitis C virus coinfection among injection drug users in the southeastern region of Yunnan, China. J Acquir Immune Defic Syndr. 2002 Feb 1; 29 (2): 191-6.
8. Kusagawa S, Takebe Y, Yang R, Motomura K, Ampofo W, Brandful J, Koyanagi Y, Yamamoto N, Sata T, Ishikawa K, Nagai Y, Tatsumi M.(2001) Isolation and characterization of a full-length molecular DNA clone of Ghanaian HIV type 1 intersubtype A/G recombinant CRF02_AG, which is replication competent in a restricted host range. AIDS Res Hum Retroviruses. 2001 May 1; 17 (7): 649-55.
9. Sato H, Tomita Y, Ebisawa K, Hachiya A, Shibamura K, Shiino T, Yang R, Tatsumi M, Gushi K, Umeyama H, Oka S, Takebe Y, Nagai Y.(2001) Augmentation of human immunodeficiency virus type 1 subtype E (CRF01_AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase. J Virol. 2001 Jun; 75 (12): 5604-13.
10. Kato K, Kusagawa S, Motomura K, Yang R, Shiino T, Nohtomi K, Sato H, Shibamura K, Nguyen TH, Pham KC, Pham HT, Duong CT, Nguyen TH, Bui DT, Hoang TL, Nagai Y, Takebe Y.(2001) Closely related HIV-1 CRF01_AE variant among injecting drug users in northern Vietnam: evidence of HIV spread across the Vietnam-China border. AIDS Res Hum Retroviruses. 2001 Jan 20; 17 (2): 113-23.