学术带头人：朱应教授

朱应教授研究方向为病毒学与分子病理学。1987年毕业于武汉大学病毒学及分子生物学系，获学士学位。1998年毕业于武汉大学生命科学学院，获微生物学博士学位。1987-1995年，先后任武汉大学病毒学研究所助教，讲师，主要从事昆虫病毒及肝炎病毒研究。1999年美国贝勒医学院生化及分子生物学系，博士后研究。参与课题主要内容包括研究两种蛋白磷酸激酶及其相关细胞因子在细胞DNA损伤修复过程中的作用。2000-2002年，美国德州大学医学院(Houston)内科系博士后。参与的研究课题包括：细胞炎症因子环加氧酶（COX-2）在哺乳动物细胞中转录调控的研究，PMA及肿瘤坏死因子激活COX-2在人成纤维细胞HFF中表达的分子机制；阿司匹林抑制COX-2研究，主要从转录水平研究阿司匹林抑制COX-2启动子活性的分子机制。2002年作为引进人才回校工作，2003年任教授，2004年获博士生导师资格。

目前主要从事乙肝病毒致癌机制和SARS病毒、流感病毒感染导致基于COX-2途径的致炎机理研究。曾在J Biol Chem、Circulation、Virus Research等SCI刊源发表论文18篇。

发表的论文
1. Zhu Y, Saunders MA, Yeh H, Deng W, Wu KK. 2002. Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/ehancer binding proteins. J Biol Chem. 277 (9): 6923-6928. （IF: 6.7）

2. Schroer K*, Zhu Y*， Saunders MA, Deng WG, Xu XM, Meyer-Kirchrath J, Wu KK. 2002. Obligatory role of cyclic adenosine monophosphate response element in cyclooxygenase-2 promoter induction and feedback regulation by inflammatory mediators. Circulation. 105(23):2760-5. *并列第一作者（IF: 10.3）

3. Deng WG, Zhu Y, Wu KK. 2004. Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators. Blood. 103(6):2135-42. （IF: 9.6）
4. Timani KA, Ye L, Ye L, Zhu Y, Wu Z, Gong Z. 2004. Cloning, sequencing, expression, and purification of SARS-associated coronavirus nucleocapsid protein for serodiagnosis of SARS. J Clin Virol. 30(4):309-12（IF: 2.0）

5. Deng WG, Zhu Y, Wu KK. 2003. Upregulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha induced cyclooxygenase-2 promoter activation. J Biol Chem. 278(7):4770-7. （IF: 6.7）

6. Deng WG, Zhu Y, Montero A, Wu KK. 2003. Quantitative analysis of binding of transcription factor complex to biotinylated DNA probe by a streptavidin-agarose pulldown assay. Anal Biochem. 323(1):12-8. （IF: 2.4）

7. Wang Y, Qi Y, Zhu Y, Li Z and Yang Y. 2003. Functional study on baculovirus anti-apoptosis genes. Molecular and cellular biochemisty. 252: 103-107. （IF: 1.0）

8. Cieslik K, Zhu Y and Wu KK 2002. Salicylate suppresses macrophage nitric-oxide synthase-2 and cyclo-oxygenase-2 expression by inhibiting CCAAT/enhancer binding protein-beta binding via a common signaling pathway. J Biol Chem. 277(51):49304-10. （IF: 6.7）

9. Deng W, Saunders M, Gilroy D, He X, Yeh H, Zhu Y, Shtivelband M, Ruan K and Wu K.K. 2002. Purification and characterization of a cyclooxygenase-2 and angiogenesis suppressing factor produced by human fibroblasts. FASEB J. 16(10):1286-8. （IF: 7.3）

10. Zhu, Y., Liu, M., Zhao, W., Zhang, J., Wang, K., Gu, C., .Wu, K., Li, Y., Zheng, C., Xiao, G., Yan, H., Hang, J., Guo, D., Tien, P. and J. Wu. 2005. Isolation of virus from a SARS patient and genome-wide analysis of genetic mutations related to pathogensis and epidemology form 47 SARS-Cov isolateds. Virus Genes. 30(1)：93-102. （IF: 1.5）

11. Zhu Y, Qi YP, Liu ZY, Xiao GF. 1998. Baculovirus-mediated gene transfer into mammalian cells. Science in China (Series C). 41 (5): 473-478. (IF 0.5)
12. Zhu Y, Qi YP. 1999. Construction of transposon-mediated baculovirus vector and expression of green fluorescent protein in insect cells and larvae. Chinese Science Bulletin. 44 (2): 158-162. (IF 0.57)

13. Zhu Y, Qi Y, Liu D, Joshua MN, Wang Y. 1998. A novel expression system based on host-range expansion of baculovirus. J Virol Methods. 76(1-2):101-8. (IF 1.9)

14. Zhang, J., Zhao, W., Li, Y., Cheng, M., Zhu, Y*. and J. Wu*. 2005. Human hepatitis B virus X protein inhibits cell apoptosis and promotes tumorgenesis through interacting with a serine protease Hepsin. Arch. Virol. 150(4):721-41. 通讯作者（IF: 1.9）

15. Yan, Y.F., Chen, X., Zhu, Y., Wu, J., and C.Y. Dong. 2005. Selective cytolysis of tumor cells by mumps virus S79. Intervirology 48(5):292-296

16. Wu, K., Zhang, X., Yang, Y., Mu, Y., Liu, M., Lu, L., Li, Y., Zhu, Y. and J. Wu. 2005. Inhibition of hepatitis B virus gene expression by single and dual small interfering RNA treatment. Virus Research. 112: 100-107.

17. Hussain S, Pan J, Chen Y, Yang Y, Xu J, Peng Y, Wu Y, Li Z, Zhu Y, Tien P, Guo D. 2005. Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus. J Virol. 79(9):5288-5295.

18. Cieslik KA, Zhu Y, Shtivelband M, Wu KK. 2005. Inhibition of p90 ribosomal S6 kinase-mediated CCAAT/enhancer-binding protein beta activation and cyclooxygenase-2 expression by salicylate. J Biol Chem. 280(18):18411-18417