感染与免疫中心 海外团队：陈列平教授
陈列平
客座研究员，中国科学院“海外百人计划”获得者
陈列平 男，1960年4月出生，博士。
于1989年获得Medical College of Pennsylvania-Hahnemann Medical College博士学位，并于1989至1990年在University of Washington School of Medicine从事博士后研究。1990年至1997年在Bristol-Myers Squibb Pharmaceutical Research Institute工作，历任研究员，高级研究员，首席科学家。从1997年至今在Mayo Clinic任职，现为免疫学教授。曾获Bristol-Myers Squibb Presidential Award 及 Kirin Lectureship, University of Texas Southwestern Medical Center等奖。近五年来在Nature Medicine, Immunity, JEM等刊物上发表数十篇论文。主要研究方向为:1）共刺激分子对免疫应答中的T细胞的诱导、分化和成熟的调节机制；2)共刺激分子的调控在慢性HCV感染和肝癌的动物模型与临床病理模型中的作用。
Email: chen.lieping@mayo.edu
研究组成员：
教授： 陈列平
博士研究生： 王俊 韩雪
Selected Publications:
1. Dong, H., Zhu, G., Tamada, K., Flies, D. B., van Deursen, JMA & Chen, L. (2004) B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes. Immunity 20: 327-336
2. Sica, G. L., Choi, I. H., Zhu, G., Tamada, K., Wang, S., Tamura, H., Chapoval, A. I., Flies, D. B., & Chen, L. (2003) B7-H4, a molecule of the B7 family, negatively regulates T-cell immunity. Immunity 18: 849-861
3. Curiel, T. J., Wei, S., Dong, H., Alvarez, X., Krzysiek, R., Cheng, J., Knuston, K., Mottram, P., Daniel, B., Chen, L.* & Zou W.* (2003) Blockade of B7-H1 improves myeloid dendritic cell-mediated anti-tumor immunity. Nature Med. 9: 562-567, (*shared senior authorship)
4. Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., & Chen, L. (2002) Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nature Med. 8: 793-800
5. Chapoval, A. I., N, I. J., Lau, J. S., Wilcox, R. A., Flies, D. B., Dong, H., Sica, G. L., Zhu, G., Tamada, K. and Chen, L. (2001) B7-H3: A costimulatory molecule for T cell activation and IFN-gamma production. Nature Immunol. 2: 269-274
English Version
Dr. Lieping Chen is an Adjunct Investigator at the Institute of Biophysics, Chinese Academy of Sciences. Currently he is Professor of Dermatology, Oncology and Immunology, Director of Dermatology Research and Investigator, Institute for Cell Engineering in the Johns Hopkins University School of Medicine in Baltimore, Maryland. Research focus of his laboratory is to identify and characterize co-signal molecules which control T lymphocyte activation and tolerance. Co-signal molecules are among the earliest responding elements of the immune system to antigens and are essential for the communication of a T lymphocyte with host cells. His laboratory has first demonstrated the role of costimulatory B7 molecules in the stimulation of immune responses against cancers. These studies support the hypothesis that lack of sufficient costimulation contributes to cancer progression. His laboratory has also identified and characterized a series of new co-signaling molecules in the B7 family and in the tumor necrosis factor (TNF) superfamily including B7-H1, B7-H2, B7-H3, B7-H4, LIGHT, RELT and CD137. His current research interest includes structural biology, biochemical signaling and immunological functions of co-signal molecules and their applications for treating cancer, autoimmune diseases, transplantation rejection, inflammation and viral infection.
