感染与免疫中心 海外团队：程根洪教授
程根洪
客座研究员 中国科学院“海外百人计划”获得者
程根洪 男，1961年8月出生，博士。于1990年获得Albert Einstein College of Medicine博士学位，并于1990至1996年在Albert Einstein College of Medicine，Rockefeller University及Massachusetts Institute of Technology从事博士后研究。从1996年至今在University of California Los Angeles任职，现为微生物学及分子遗传学系副教授。曾获Stop Cancer Award 及 Leukemia & Lymphoma Society Scholar Award等奖。近五年来在Nature,Immunity,PNAS等刊物上已发表数十篇论文。主要研究方向为: 1）Toll-like receptor (TLR)介导的固有免疫及其在抗SARS-CoV中的应用；2)建立一somatic knockout体系以研究基因在细胞信号传导及激活中的作用；3）建立体内及体外模型以跟踪常见病原体感染后天然免疫及获得性免疫反应分子过程。
Email: genhongc@microbio.ucla.edu
研究组成员：
教授： 程根宏
博士研究生： 陈刚 郑大海
Selected Publications:
1. O’Connell, R. M., Saha, S. K., Vaidya, S. A., Bruhn, K. W., Gustavo, A. Miranda, G. A., Brian Zarnegar, B., and Cheng, G. (2004) Type I Interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med. 200:437-445
2. Doyle, S. E., O’Connell, R. M., Miranda, G. A., Vaidya, S. A., Chow, E. K., Liu, P. T., Cheng, G. (2004) Toll-like Receptors Induce a Phagocytic Gene Program through p38. J Exp Med. 199: 81-90
3. Zarnegar, B., He, J., Oganesyan, G., Hoffmann, A., Baltimore, D. and Cheng, G. (2004) Unique CD40-mediated biological program in B-cell activation requires both type 1 and type 2 NF-kB activation pathways. Proc. Natl. Acad. Sci. USA 101: 8108-8113
4. Chin, A. I., Dempsey, P. W., Bruhn, K., Miller, J. F., Xu, Y., and Cheng, G. (2002) Involvement of Receptor Interacting Protein 2 in Innate and Adaptive Immune Responses. Nature 416: 190-194
5. Doyle, S. E., Vaidya, S. A., O’Connell, R., Dadgostar, H., Dempsey, P. W., M. Cheng, G. (2002) IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program. Immunity 17: 251-263
English Version
Dr. Cheng was born in 1963, and earned his doctor’s degree at Albert Einstein College of Medicine in 1990. He completed his post-doctoral research at Rockefeller University and Massachusetts Institute of Technology. He has received many awards, including Stop Cancer Award, Leukemia & Lymphoma Society Scholar Award and NIH Merit Award. Now he is a professor in Department of Microbiology, Immunology & Molecular Genetics at University of California Los Angeles. He is also an adjunct professor at Chinese Academy of Sciences. He studies signal transduction and gene expression network through the TNF receptor, Toll-like receptor (TLR), and Nod families during the process of innate and adaptive immune responses. His laboratory has established numerous comprehensive systems using biochemical and microarray analyses, cell-based assays, as well as animal models to determine the role and the specificity of individual receptors, signaling pathways and their targeting molecules in host defense against pathogen infections and cancer formation.
