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感染与免疫中心 海外团队：傅阳心教授

八月 12th, 2007 | posted by biolab-ibp
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感染与免疫中心 海外团队：傅阳心教授
傅阳心
客座研究员 中国科学院“海外百人计划”获得者

傅阳心 男，1958年5月出生，博士。
于1990年获得University of Miami博士学位，并于1991至1993年在National Jewish Center for Immunology and Respiratory Medicine, Denver从事博士后研究。1994年至1998年在Washington University School of Medicine担任住院医生。从1998年至今在University of Chicago任职，现为病理学系助理教授，主治医生。曾获Howard Hughes Medical Institute Fellowship for Physician Scientist及 NIH Clinical Investigator Award等奖。近五年来在Nature Medicine,Immunity,JEM,PNAS等刊物上已发表数十篇论文。

主要研究方向为:
 1）淋巴毒素在淋巴组织发育和功能中的作用；
2) 淋巴组织内外共刺激在免疫反应中的作用；
3）淋巴毒素在自身免疫性肝炎和病毒感染后肝再生中的作用。

Email: yfu@midway.uchicago.edu

 研究组成员：
 
教授： 傅阳心
博士研究生： 赵洁   姜竺君

Selected Publications:
1. Yu, P, Lee, Y, Liu, W, Chin, R, Wang, J, Wang, Y, Schietinger, A, Schreiber, H and Fu. Y.（2004） Priming and expansion of naïve T cells inside tumors lead to the rejection of established tumors at local and distal sites. Nature Immunology. 5: 141-49

2. Subudhi, S. K., Zhou, P., Yerian, L. M., Chin, R. K., Lo, J. C., Anders, Fu, Y. (2004) Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J. Clin. Invest. 113: 694-700

3. Chin, RK, Lo, J.C., Kim, O, Blink, S.E. Christiansen, PA, Wang, Y, Fu, Y.（2003） Lymphotoxin pathway directs AIRE-mediated negative selection. Nature Immunology. 4: 1121-7

4. Sun, Y., Chen, H.M., Subudhi, S.K., Chen, J., Chen, L., Fu, Y.（2002） Costimulatory molecular-targeted antibody therapy of a spontaneous autoimmune disease. Nature Medicine. 8: 1404-13

5.  Chin, R., Zhou, P., Alegre, M., and Fu, Y. (2001) Confounding factors complicate conclusions in aly model. Nature Medicine. 7:1165-66

English Version

Dr. Fu was born in 1958, and earned his doctor’s degree in University of Miami in 1990. He was a post-doctoral fellowship in National Jewish Center for Immunology and Respiratory Medicine in 1991~1993. He received NIH Clinical Investigator Award and Howard Hughes Medical Institute Fellowship for Physician Scientist. Now he is Professor of Department of Pathology and Immunology in University of Chicago. He is also an adjunct professor at Chinese Academy of Sciences. The basic research in his laboratory is focused on understanding the biological consequences arising from the interaction between core molecules of the TNF superfamily, lymphotoxin (LT or TNFSF1) and LIGHT (TNFSF14), on lymphocytes, and their receptor, LTßR, on stromal cells. His recent studies have defined the roles of these molecules in autoimmunity and tumor immunity in mouse models and human patients. These research includes four major themes: critical role for lymphotoxin in the development and function of lymphoid tissues, role of lymphotoxin in the remodeling or regeneration of non-lymphoid tissues, the role of lymphotoxin receptor in central and peripheral tolerance, therapies based on the regulation of lymphotoxin or LIGHT signaling.

实验室简介
实验室简介: 生物物理研究所 感染与免疫中心