感染与免疫中心 海外团队：苏立山教授
苏立山
客座研究员 中国科学院“海外百人计划”获得者
苏立山 男，1959年7月出生，博士。
于1989年获得Harvard Medical School博士学位，并于1989至1993年在Stanford University从事博士后研究。
1993年至1996年在SyStemix, Inc.工作，曾任资深科学家。
从1996年至今在University of North Carolina-Chapel Hill任职，现为微生物与免疫学系副教授。
曾获March of Dimes Basil O’Connor Scholar Award及 Jefferson Pilot Award等奖。近五年来在Genes & Dev., J. Virol, J.Immunol.等刊物上已发表数十篇论文。
主要研究方向为:
1）找寻抑制HIV复制的CD8+ T细胞旁分泌因子；
2) non-cytolytic immune modulators抑制HIV复制的机理。
Email:lishan_su@med.unc.edu
研究组成员：
教授： 苏立山
博士研究生： 傅继欢 丁寄威
助理研究员： 师晓栋
Selected Publications:
1. Coffield, V.M.，Helms, W., Jiang, Q. and Su, L, (2004) Ga13 mediates a signal that is critical for early thymocyte proliferation and survival. J. Exp. Med. 328(10):1315-1324 (Published online 8 November 2004 as 10.1084/ jem. 20040944) .
2. Meissner, E.G. , K. Duus, F. Gao, X. Yu and Su, L. (2004) Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope gene. Virology 328(1):74-88.
3. Gebuhr, T.*, G. Kovalev*, S. Bultman, V. Godfrey, Su, L. and T. Magnuson (2003) The role of Brg1, a catalytic subunit of mammalian chromatin remodeling complexes, in T cell development. J. Exp. Med. 198: 1937-1949 (* indicates co-first authorship).
4. Coffield, V. M., Jiang, Q. and Su, L. (2003) A Novel Genetic Approach to Inactivating Chemokine Receptors by a Modified Viral Protein. Nat. Biotechnol. 21(11):1321-1327.
5. Miller, E., Smith, J., Lichtinger, M., Wang L. and Su, L. (2003) Activation of the signal transducer and activator of transcription 1 signaling pathway in thymocytes from HIV-1-infected human thymus. AIDS 17:1269-1277.
Dr. Su received his B.S. degree from Shandong University in 1982, and his Ph.D. degree in Virology from Harvard University in 1989. He completed his post-doctoral training in Immunology in 1993 at Stanford University. He was a scientist-senior scientist at SyStemix-Sandoz-Novartis from 1993-1996.He received March of Dimes Basil O’Connor Scholar Award and Jefferson Pilot Award. Now he is an associate professor at The University of North Carolina-Chapel Hill. He is also an adjunct professor at Chinese Academy of Sciences. His laboratory studies T cells during normal (T cell development and activation) and pathogenic (AIDS and leukemia) hemato-lymphopoiesis. The current research focuses on the following: 1) 1. HIV-1 replication and pathogenesis in the human thymus. 2) Development and immune functions of regulatory T (Treg) cells. 3) A Novel Ga13-p115-RhoA Pathway in T Cell Activation and HIV-1 Replication. 4) Migration and differentiation of hematopoietic stem cells (HSPC) during T cell development.
