课 题 组 介 绍
一、课题组长:
罗泽伟,教授,专长理论群体与数量遗传学。先后主持由国家自然科学杰出青年基金、国家自然科学基金重大、重点及面上项目、973计划、863计划、教育部以及上海市等资助的研究项目。在复杂遗传性状多基因遗传结构解析的理论与方法学研究、同源多倍体遗传连锁图构建的理论与方法学研究、重复基因表达的遗传控制与分子进化研究以及非小细胞肺癌等复杂遗传疾病的分子病因学的实验研究等领域获得了国际学术界公认的研究成果。在国际遗传学核心刊物
PNAS、Genetics、Heredity、TAG、JCEM
等刊物发表科学论文30余篇。截止至2006年2月，这些论文被SCI收录的Nature Review Genetics, Science,
PNAS, Genetics, Genome Research, Development 等 77
种国际核心刊物上发表的233余篇科学论文引用共316次（他引254次）。1997年荣获国家教委科技进步二等奖，1998年荣获香港"
求是"基金会杰出青年学者奖(生物医学类)， 1999年荣获上海市自然科学牡丹奖,
同年受聘教育部首批"长江"学者奖励计划特聘教授，2004年荣获上海市科技进步一等奖。
二、课题组成员名单:
ˉ 罗泽伟，男，1957年10月生。英国伯明翰大学遗传学博士。现任复旦大学遗传所教授，博士生导师。电子邮件:
zwluo@fudan.edu.cn；
ˉ 王久存，女，1966年10月生。日本国立福井大学生物应用化学专业博士。现任复旦大学遗传所副教授。电子邮件:
jcwang@fudan.edu.cn；
ˉ 张荣梅，女，1974年3月生。复旦大学遗传学博士。现任复旦大学遗传所讲师。电子邮件：rmzhang@fudan.edu.cn；
ˉ
实验室现有在读博士生5人，硕士生3人，分别从事非小细胞肺癌等人类复杂遗传疾病分子病因学的研究以及多基因性状复杂遗传结构的定位分离与克隆的理论及实验研究。
三、课题组研究方向:
ˉ 复杂遗传性状多基因遗传结构解析的理论与方法学研究;
ˉ 同源多倍体遗传连锁图构建的理论与方法学研究;
ˉ 重复基因表达的遗传控制与分子进化;
ˉ 非小细胞肺癌等复杂遗传疾病的分子病因学的实验研究。
四、代表性研究成果（1997-2005主要论文）:
1. Luo ZW*, Zhang RM, Kearsey MJ. (2004b). Theoretical basis for
genetic linkage analysis in autotetraploid species. Proc Natl Acad
Sci USA. 101 (18): 7040-7045. (IF=10.5)
2. Zhang Z*, Luo ZW*, Kishino H, Kearsey MJ. (2005). Divergence
pattern of duplicate genes in protein-protein interactions follows
the power law. Mol Biol Evol. 22 (3): 501-505. (IF=6.355)
3. Chu JH, … Luo ZW*. (2002). Male fertility is compatible with an
Arg(840)Cys substitution in the AR in a large Chinese family
affected with divergent phenotypes of AR insensitivity syndrome. J
Clin Endocr Metab. 87 (1): 347-351. (IF=5.778)
4. Zhang HT, … Luo ZW*. (2004). Defective expression of transforming
growth factor beta receptor type II is associated with CpG
methylated promoter in primary non-small cell lung cancer. Clin
Cancer Res. 10 (7): 2359-2367. (IF=5.623)
5. Qi QY, … Luo ZW*. (2003). Induced recovery of defective membrane
expression of a CC chemokine receptor 5 mutant by
phytohemagglutinin. Cell Mol Life Sci. 60(11): 2492-2500. (IF=4.812)
6. Luo ZW*, Zhang Z, Zhang RM, et al. (2006a). Modeling Population
Genetic Data in Autotetraploid Species. Genetics. 172(1): 639-646.
(IF=4.138)
7. Luo ZW*, Zhang Z, Leach L, et al. (2006b). Constructing genetic
linkage maps under a tetrasomic model. Genetics. Jan 16; [Epub ahead
of print]. (IF=4.138)
8. Luo ZW*, Zhang Z. (2005). Commentary on Wu and Ma. Genetics.
171(4): 2149-2150. (IF=4.138)
9. Luo ZW*, Wu CI, Kearsey MJ. (2002). Precision and high-resolution
mapping of quantitative trait loci by use of recurrent selection,
backcross
or intercross schemes. Genetics. 161 (2): 915-929. (IF=4.138)
10. Luo ZW*, Wu CI. (2001a). Modeling linkage disequilibrium between
a polymorphic marker locus and a locus affecting complex dichotomous
traits in natural populations. Genetics. 158 (4): 1785-1800.
(IF=4.138)
11. Luo ZW*, Hackett CA, Bradshaw JE, McNicol JW, Milbourne D.
(2001b). Construction of a genetic linkage map in tetraploid species
using molecular markers. Genetics. 157 (3): 1369-1385. (IF=4.138)
12. Luo ZW*, Tao SH, Zeng ZB. (2000a). Inferring linkage
disequilibrium between a polymorphic marker locus and a trait locus
in natural populations. Genetics. 156 (1): 457-467. (IF=4.138)
13. Luo ZW*, Suhai S. (1999). Estimating linkage disequilibrium
between a polymorphic marker locus and a trait locus in natural
populations. Genetics. 151 (1): 359-371. (IF=4.138)
14. Luo ZW*, Thompson R, Woolliams JA. (1997). A population genetics
model of marker-assisted selection. Genetics. 146 (3): 1173-1183.
(IF=4.138)
15. Luo ZW*, Hackett CA, Bradshaw JE, McNicol JW, Milbourne D.
(2000b). Predicting parental genotypes and gene segregation for
tetrasomic inheritance. Theor Appl Genet. 100 (7): 1067-1073.
(IF=2.981)
16. Zhang HT, … Luo ZW*. (2003). Mutational analysis of the
transforming growth factor beta receptor type I gene in primary
non-small cell lung cancer. Lung Cancer-J IASLC. 40 (3): 281-287.
(IF=2.914)
17. Fei QY, … Luo ZW*. (2003). Defected expression of E-cadherin in
non-small cell lung cancer. Lung Cancer-J IASLC. 37 (2): 147-152.
(IF=2.914)
18. Wang MH, … Luo ZW*. (2005). Dissecting phenotypic variation
among AIS patients. Biochem Bioph Res Co. 335 (2): 335-342.
(IF=2.904)
19. Luo ZW*. (1998). Detecting linkage disequilibrium between a
polymorphic marker locus and a trait locus in natural populations.
Heredity. 80: 198-208. (IF=2.016)
20. Luo ZW*, Ma L. (2004a). An improved formulation of marker
heterozygosity in recurrent selection and backcross schemes. Genet
Res. 83 (1): 49-53. (IF=1.978)
21. Tao SH, …… Luo ZW*. (2002). High-resolution gene mapping using
admixture linkage disequilibrium. Chinese Sci Bull. 47 (20):
1717-1719. (IF=0.683)
22. Tao SH, …… Luo ZW*. (2001). Rate of decay in admixture linkage
disequilibrium and its implication in gene mapping. Chinese Sci
Bull. 46 (5): 358-363. (IF=0.683)
23. Tao SH, …… Luo ZW*. (2001). A population genetics model of
linkage disequilibrium in admired populations. Chinese Sci Bull. 46
(3): 193-197. (IF=0.683)
24. Luo ZW*, Zhang RM. (1999). Theoretical strategies for
high-resolution mapping of complex genetic disorders in humans.
Chinese Sci Bull. 44 (3): 193-198. (IF=0.683)
罗泽伟,教授,专长理论群体与数量遗传学。先后主持由国家自然科学杰出青年基金、国家自然科学基金重大、重点及面上项目、973计划、863计划、教育部以及上海市等资助的研究项目。在复杂遗传性状多基因遗传结构解析的理论与方法学研究、同源多倍体遗传连锁图构建的理论与方法学研究、重复基因表达的遗传控制与分子进化研究以及非小细胞肺癌等复杂遗传疾病的分子病因学的实验研究等领域获得了国际学术界公认的研究成果。在国际遗传学核心刊物
PNAS、Genetics、Heredity、TAG、JCEM
等刊物发表科学论文30余篇。截止至2006年2月，这些论文被SCI收录的Nature Review Genetics, Science,
PNAS, Genetics, Genome Research, Development 等 77
种国际核心刊物上发表的233余篇科学论文引用共316次（他引254次）。1997年荣获国家教委科技进步二等奖，1998年荣获香港"
求是"基金会杰出青年学者奖(生物医学类)， 1999年荣获上海市自然科学牡丹奖,
同年受聘教育部首批"长江"学者奖励计划特聘教授，2004年荣获上海市科技进步一等奖。
二、课题组成员名单:
ˉ 罗泽伟，男，1957年10月生。英国伯明翰大学遗传学博士。现任复旦大学遗传所教授，博士生导师。电子邮件:
zwluo@fudan.edu.cn；
ˉ 王久存，女，1966年10月生。日本国立福井大学生物应用化学专业博士。现任复旦大学遗传所副教授。电子邮件:
jcwang@fudan.edu.cn；
ˉ 张荣梅，女，1974年3月生。复旦大学遗传学博士。现任复旦大学遗传所讲师。电子邮件：rmzhang@fudan.edu.cn；
ˉ
实验室现有在读博士生5人，硕士生3人，分别从事非小细胞肺癌等人类复杂遗传疾病分子病因学的研究以及多基因性状复杂遗传结构的定位分离与克隆的理论及实验研究。
三、课题组研究方向:
ˉ 复杂遗传性状多基因遗传结构解析的理论与方法学研究;
ˉ 同源多倍体遗传连锁图构建的理论与方法学研究;
ˉ 重复基因表达的遗传控制与分子进化;
ˉ 非小细胞肺癌等复杂遗传疾病的分子病因学的实验研究。
四、代表性研究成果（1997-2005主要论文）:
1. Luo ZW*, Zhang RM, Kearsey MJ. (2004b). Theoretical basis for
genetic linkage analysis in autotetraploid species. Proc Natl Acad
Sci USA. 101 (18): 7040-7045. (IF=10.5)
2. Zhang Z*, Luo ZW*, Kishino H, Kearsey MJ. (2005). Divergence
pattern of duplicate genes in protein-protein interactions follows
the power law. Mol Biol Evol. 22 (3): 501-505. (IF=6.355)
3. Chu JH, … Luo ZW*. (2002). Male fertility is compatible with an
Arg(840)Cys substitution in the AR in a large Chinese family
affected with divergent phenotypes of AR insensitivity syndrome. J
Clin Endocr Metab. 87 (1): 347-351. (IF=5.778)
4. Zhang HT, … Luo ZW*. (2004). Defective expression of transforming
growth factor beta receptor type II is associated with CpG
methylated promoter in primary non-small cell lung cancer. Clin
Cancer Res. 10 (7): 2359-2367. (IF=5.623)
5. Qi QY, … Luo ZW*. (2003). Induced recovery of defective membrane
expression of a CC chemokine receptor 5 mutant by
phytohemagglutinin. Cell Mol Life Sci. 60(11): 2492-2500. (IF=4.812)
6. Luo ZW*, Zhang Z, Zhang RM, et al. (2006a). Modeling Population
Genetic Data in Autotetraploid Species. Genetics. 172(1): 639-646.
(IF=4.138)
7. Luo ZW*, Zhang Z, Leach L, et al. (2006b). Constructing genetic
linkage maps under a tetrasomic model. Genetics. Jan 16; [Epub ahead
of print]. (IF=4.138)
8. Luo ZW*, Zhang Z. (2005). Commentary on Wu and Ma. Genetics.
171(4): 2149-2150. (IF=4.138)
9. Luo ZW*, Wu CI, Kearsey MJ. (2002). Precision and high-resolution
mapping of quantitative trait loci by use of recurrent selection,
backcrossor intercross schemes. Genetics. 161 (2): 915-929. (IF=4.138)
10. Luo ZW*, Wu CI. (2001a). Modeling linkage disequilibrium between
a polymorphic marker locus and a locus affecting complex dichotomous
traits in natural populations. Genetics. 158 (4): 1785-1800.
(IF=4.138)
11. Luo ZW*, Hackett CA, Bradshaw JE, McNicol JW, Milbourne D.
(2001b). Construction of a genetic linkage map in tetraploid species
using molecular markers. Genetics. 157 (3): 1369-1385. (IF=4.138)
12. Luo ZW*, Tao SH, Zeng ZB. (2000a). Inferring linkage
disequilibrium between a polymorphic marker locus and a trait locus
in natural populations. Genetics. 156 (1): 457-467. (IF=4.138)
13. Luo ZW*, Suhai S. (1999). Estimating linkage disequilibrium
between a polymorphic marker locus and a trait locus in natural
populations. Genetics. 151 (1): 359-371. (IF=4.138)
14. Luo ZW*, Thompson R, Woolliams JA. (1997). A population genetics
model of marker-assisted selection. Genetics. 146 (3): 1173-1183.
(IF=4.138)
15. Luo ZW*, Hackett CA, Bradshaw JE, McNicol JW, Milbourne D.
(2000b). Predicting parental genotypes and gene segregation for
tetrasomic inheritance. Theor Appl Genet. 100 (7): 1067-1073.
(IF=2.981)
16. Zhang HT, … Luo ZW*. (2003). Mutational analysis of the
transforming growth factor beta receptor type I gene in primary
non-small cell lung cancer. Lung Cancer-J IASLC. 40 (3): 281-287.
(IF=2.914)
17. Fei QY, … Luo ZW*. (2003). Defected expression of E-cadherin in
non-small cell lung cancer. Lung Cancer-J IASLC. 37 (2): 147-152.
(IF=2.914)
18. Wang MH, … Luo ZW*. (2005). Dissecting phenotypic variation
among AIS patients. Biochem Bioph Res Co. 335 (2): 335-342.
(IF=2.904)
19. Luo ZW*. (1998). Detecting linkage disequilibrium between a
polymorphic marker locus and a trait locus in natural populations.
Heredity. 80: 198-208. (IF=2.016)
20. Luo ZW*, Ma L. (2004a). An improved formulation of marker
heterozygosity in recurrent selection and backcross schemes. Genet
Res. 83 (1): 49-53. (IF=1.978)
21. Tao SH, …… Luo ZW*. (2002). High-resolution gene mapping using
admixture linkage disequilibrium. Chinese Sci Bull. 47 (20):
1717-1719. (IF=0.683)
22. Tao SH, …… Luo ZW*. (2001). Rate of decay in admixture linkage
disequilibrium and its implication in gene mapping. Chinese Sci
Bull. 46 (5): 358-363. (IF=0.683)
23. Tao SH, …… Luo ZW*. (2001). A population genetics model of
linkage disequilibrium in admired populations. Chinese Sci Bull. 46
(3): 193-197. (IF=0.683)
24. Luo ZW*, Zhang RM. (1999). Theoretical strategies for
high-resolution mapping of complex genetic disorders in humans.
Chinese Sci Bull. 44 (3): 193-198. (IF=0.683)
