研究方向：细胞间的分子识别与发育
    作为生命活动的结构与功能单位，细胞与外界环境之间的信息交流是生物界普遍存在的重要事件；而在多细胞生物中，细胞与细胞之间的识别更是广泛存在，涉及到细胞的分裂、分化直至个体发育几乎所有过程，也涉及多种疾病的病理过程。本研究组主要应用遗传学、分子生物学等手段，结合模式生物开展下列研究：
1、细胞间的分子识别在免疫和神经系统中作用的比较研究。 MHC是人类最具多态性的遗传系统，其基因产物参与免疫系统中的抗原提呈。但它的广泛分布提示它具有多种功能，如肿瘤发生乃至神经发育。本研究组和本实验室相关课题组合作，进一步研究中国高发肿瘤中HLA的表达在免疫识别（TCL，NK等）作用，以及在神经发育与疾病中的可能作用。
2、突触形成、神经系统的发育与相关疾病。突触的形成和维持不但是神经系统发育所必需，而且与学习记忆等高级神经活动密切相关。许多与神经发育有关的疾病都与突触调制和维持有关。本研究组以神经元表面蛋白分子为研究对象，通过建立转基因果蝇模型，研究它们在神经发育及高级神经活动中的作用，并和本实验室相关课题组合作在RNA调控、DNA甲基化修饰等表观遗传水平上，探讨果蝇神经系统发育与孤独症的发生机制。
3、用于疾病诊治的标志物研究。通过生物工程技术，探讨基础研究成果的应用价值。

课题组长简介
谢维
    1981年参加工作；1995.10毕业于南京大学生物化学系，获博士学位；1997.1-1998.12在美国The University of Rochester Medical Center作博士后；1999.5-2001.8在加拿大The Hospital for Sick Children, University of Toronto做博士后、访问学者；2003.10-2004.1在德国Max Planck Institute of CBG in Dresden作高访学者。1991年至今，在东南大学医学院从事医学生物学、遗传学的教学、科研工作（教育部发育与疾病相关基因重点实验室）。教育部“长江学者奖励计划”特聘教授。获得国家自然科学基金、国家杰出青年科学基金、“973重大基础研究项目”、美国NIH基金(RO3)等资助。
研究梯队：
教师：谢维、刘琍、汪道涌、刘加彬、甘光明、韦柳婵
博士研究生：曾宪坤、陆军、刘加彬、甘光明、孙明宽、瞿国润
硕士研究生：徐敏、陈发定、刘力娟、吴红燕

本课题组日常负责人联系方式：
刘琍 025-83271314(83272504)-804

近期论文

1. Yu-Qing Shen, Jian-Qiong Zhang, Mei Xia, Feng-Qing Miao, Xiang-Nian Shan, Wei Xie. LMP2/LMP7 Molecules Abnormality Underline the Downregulation of HLA Class I Antigen in a Hepatocellular Carcinoma Cell Line. Journal of Gastroenterology and Hepatology (2006, in press)
2. Xue-Cai Wang, Jian-Qiong Zhang, Yu-qing Shen, Feng-Qing Miao, Wei Xie. Loss of Heterozygosity at 6p21.3 underlying HLA Class 1 Downregualtion in Gastric Cancer. Journal of Experimental and Clinical Cancer Research. 2006, 25:115-9
3. Chuanlai Shen, Mike Campoli, Chien-Chung Chang, Jianqiong Zhang, Wei Guo, Xinhui Wang, Wei Xie. Functional comparison of 3-subunit HLA-A2/MART1(27-35) monomer and 2-subunit HLA-A2/MART1(27-35) monomer with epitope-linked β2m. BBRC. 2006; 342:57-65
4. Junping Wang, Michael Sarov, Jeanette Rientjes, Jun Fu, Heike Hollak, Harald Kranz, Wei Xie, A. Francis Stewart, and Youming Zhang. An Improved Recombineering Approach by Adding RecA to Red Recombination. Molecular Biotechnology, 2006, 32(1):43-54
5. Jun Xu, Hong Fan, Zhujiang Zhao, Jianqiong Zhang, XIE Wei. The founding of hepatocellular carcinoma cell model of DNA methyltransferases 3B by RNAi and the primary Study about correlative genes in liver cancer cell. Acta Genetica Sinica,2005,32:1115-1127
6. Yu-Qing Shen, Jian-Qiong Zhang, Feng-Qing Miao, Jian-Min Zhang, Qin Jiang, Hao Chen, Xiang-Nian Shan, Wei Xie. Relationship between the downregulation of HLA class I antigen and clinicopathological significance in gastric cancer. World J Gastroenterol, 2005;11(23):3628-3631
7. Chuanlai Shen, Chien-Chung Chang, Jianqiong Zhang, Wei Guo, Fanyan meng, Wei Xie. Construction of HLA-A/peptide tetramer with peptide-linked β2 microglobulin. Journal Microbiol Immunol, 2005,2:286-294
8. 谢维.MHC基因多态性和肿瘤的发生(述评).现代免疫学杂志,2004,24(6):441-444
9. Junfei Jing, Li Liu, Liudi Yuan, Wei Xie. Preparation and characterization of polyclonal antibodies against ARL-1 protein. World Journal of Gastroenterology, 2003,9:1455-1459
10. Wan YQ; Zhu KY; Wang SZ; Wei Xie. Eukaryotic initiation factor 5. Progress in Biochemistry and Biophysics, 2002, 29(1):3-5
11. Junhao Mao, Peter Maye, Priit Kogerman, Francisco J. Tejedor, Rune Toftgard, Wei Xie, Guanqing Wu, and Dianqing Wu. Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1.Journal of Biological Chemistry.2002, 277:35156-61
12. 谢维. HLA表达与肿瘤的生物治疗(述评).中国肿瘤生物治疗杂志,2002,9(1):1-5
13. Wei Xie, Robin Battye, Gabrielle L. Boulianne. The Drosophila Dx16 gene encodes a member of the Serine/Arginine Rich family of splicing factors that affects Pattern Formation in Imaginal Discs. Developmental Biology, 2001, 235(s):273-274
14. Zhong Li*, Huiping Jiang*, Wei Xie*, Zuchuan Zhang, Alan V. Smrcka, Dianqing Wu. Roles of PLC-b2, and PLC-b3 and PI3K  in Chemoattractant-Mediated Signal Transduction. Science, 2000,287:1046-49
15. Wei Xie, Jay P. McLauglin, Gary M. Samorski, Valerie A. Romoser, Alan Smrcka, Patricia M. Hinkle, Robert A. Gross, Jean M. Bidlack, Huiping Jiang and Dianqing Wu. Genetic Alteration of PLC??3 Expression Modulates Behavioral and Cellular Responses to m Opioids. Proc. Natl. Acad. Sci. USA. 1999,96:10385-10390
16. Lin Li, Huidong Yuan, Wei Xie, Junhao Mao, Ann M. Caruso and Dianqing Wu. Dishevelled Proteins Lead to Two Signaling Pathways. Journal of Biological Chemistry, 1999, 274(1): 129-134
17. Dou Fei, Wei Xie, Dong Xueyin, Xu Xianxiu. The Terminal Structure Play an Important Role in the Biological Activity of Cecropin CMIV. Science in China (c), 1999，42(5)：494-500
18. Junhao Mao, Wei Xie, Huidong Yuan, Melvin I. Simon, Hiroyuki Mano, Dianqing Wu. Tec/Bmx Non-Receptor Tyrosine Kinases Are Involved in Regulation of Rho and Serum Response Factor by Ga?3. EMBO Journal, 1998, 17(19): 5638-5646
19. Junhao Mao, Huidong Yuan, Wei Xie, Melvin I. Simon, Dianqing Wu. Specific Involvement of G Proteins in Regulation of SRF Mediated Gene Transcription by Receptors. Journal of Biological Chemistry, 1998, 273(42): 27118-27123
20. Junhao Mao, Huidong Yuan, Wei Xie, and Dianqing Wu. GEF115 specifically Mediates Activation of Rho and SRF by Ga13. Proc. Natl. Acad. Sci. USA. 1998, 95:12973-12976
21. Huiping Jiang, Yanan Kuang, Yanping Wu, Wei Xie, Melvin I. Simon, Dianqing Wu. Roles of Phospholipase C??2 in Chemoattractant-elicited Responses. Proc. Natl. Acad. Sci. USA. 1997, 94:7971-7975
22. Wei Xie, Huiping Jiang, Yanping Wu, Diangqing Wu. Two Basic Amino Acids in the Second Inner Loop of the Interleukin-8 Receptor are Essential for G?16 Coupling. Journal of Biological Chemistry. 1997, 272(40): 24948-24951
23. Liang Wang,Haihong Wu, Fei Dou, Wei Xie, Xianxiu Xu. High-level Expression of Cecropin CMIV in E. coli from a Fusion Construct Containing the Human Tumor Necrosis Factor. Biochemistry and Molecular Biology International, 1997, 41(5): 1051-1056
24. Wei Xie, Qifeng Qiu, Xueyin Dong, Zichun Hua, Xianxiu Xu. Study on Fusion Expression Cecropin CMIV Gene from Bombyx mori in E. coli. Science in China (series c), 1997, 40(3): 225-231