丁建平
分子生物学国家重点实验室研究组组长 研究员 博士生导师 所学术委员会副主任
电话：54921433
E-mail: jpding@sibs.ac.cn
个人简介：
1982年1月毕业于南京大学，获理学学士学位；1984年10月毕业于中山大学，获理学硕士学位；1987年12月毕业于复旦大学，获理学博士学位。1987年11月至1989年6月，中国科学院上海硅酸盐研究所博士后。1989年7月至1991年8月，联邦德国柏林自由大学结晶学研究所，洪堡基金会奖研金学者。1991年9月至2001年1月，美国新泽西州罗格斯大学，先后任化学和化学生物学系助理教授、副教授和高级生物技术和医学研究中心研究员。2000年11月起，任中国科学院上海生命科学研究院生物化学与细胞生物学研究所研究员，为中科院“百人计划”引进的杰出青年学术带头人，获得2001年国家杰出青年基金资助，2006年入选新世纪百千万人才工程国家级人选。现任中国生物化学与分子生物学学会理事、蛋白质组学专业委员会主任委员、蛋白质专业委员会副主任委员、中国生物物理学会理事、中国晶体学会副秘书长和常务理事、亚洲晶体学会理事会常务理事、中国物理学会同步辐射专业委员会委员等；中国《生物化学与生物物理学报》、《生物化学与生物物理进展》和《生命的化学》编委、英国《The Biochemical Journal》编辑顾问委员会委员等。
研究方向：结构生物学
研究工作：
研究领域为结构生物学，研究工作主要是运用蛋白质结晶学、分子生物学、生物化学、细胞生物学等方法，研究生物大分子的结构和功能。目前研究工作主要围绕一些具有重要生物学意义、并且与重要疾病相关的人源蛋白质的结构和功能进行研究，特别是参与染色质修饰的蛋白质、参与营养和能量调节的mTOR信号转导通路的蛋白质、以及参与合成和分解代谢过程的重要酶蛋白等。近五年来主持、参与并完成国家、科学院和地方政府的多项重大研究项目。现已在国际重要学术刊物上发表研究论文80多篇，其中包括Nature, Nature Struct Biol, PNAS, EMBO J, J Biol Chem, Nucleic Acid Res, Structure, J Mol Biol, Biochem J, Virology等。这些研究工作不仅阐述了一些重要蛋白质分子的生物功能的结构基础、反应机理、结构和功能的关系等一系列科学问题，具有重大的科学意义；同时还为探索与这些蛋白的功能失调相关的疾病的发病机理、寻找疾病诊断的新靶标和新方法、设计和开发抗病毒和抗疾病药物等奠定了分子基础，具有重要的潜在应用价值。
发表论文：
1. Li, S., Lu, Y., Peng, B., and Ding, J*. Crystal structure of human phosphoribosylpyro-phosphate synthetase 1 reveals a new allosteric site. Biochem. J., 401, 39-47 (2007).
2. Zhang, P., Du, J., Sun, B., Dong, X., Xu, G., Zhou, J., Huang, Q., Liu, Q., Hao, Q., and Ding, J*. Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3. Nucleic Acids Res., 34, 6621-6628 (2006).
3. Zha, M., Zhong, C., Peng, Y., and Ding, J*. Crystal structures of human NUDT5 reveal the structural basis of the substrate specificity. J. Mol. Biol., 364, 1021-1033 (2006).
4. Zhang, P., Zhao, J., Wang, B., Du, J., Chen, J., and Ding, J*. The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14. Protein Science, 15, 2423-2434 (2006).
5. Cai, J., Han, C., Hu, T., Zhang, J., Wu, D., Wang, F., Liu, Y., Ding, J., Chen, K., Yue, J., Shen, X., and Jiang, H. Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: Reverse docking, enzymatic assay, and X-ray crystallography validation. Protein Science, 15, 2071-2081 (2006).
6. Shen, N., Guo, L., Yang, B., Jin, Y., and Ding, J.* Structure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity. Nucleic Acids Res., 34, 3246-3258 (2006).
7. Xie, Z.H., Huang, Y.N., Chen, Z.X., Riggs, A.D., Ding, J.P., Gowher, H., Jeltsch, A., Sasaki, H., Hata, K., and Xu, G.L. Mutations in DNA methyltransferase DNMT3B in ICF syndrome affects its regulation by DNMT3L. Hum. Mol. Genet., 15, 1375-1385 (2006).
8. Maeda, K., Das, D., Ogata-Aoki, H., Nakata, H., Miyakawa, T., Tojo, Y., Norman, R., Takaoka, Y., Ding, J., Arnold, E., Mitsuya, H. Structural and molecular interactions of CCR5 inhibitors with CCR5. J. Biol. Chem., 281, 12688-12698 (2006).
9. Liu, Y., Liao, J., Zhu, B., Wang, E., and Ding, J*. Crystal structures of the editing domain of E. coli leucyl-tRNA synthetase and its complexes with methionine and isoleucine reveal a lock-and-key mechanism for amino acid discrimination. Biochem. J., 394, 399-407 (2006).
10. Yu, Y., Li, S., Xu, X., Li, Y., Guan, K., Arnold, E., and Ding, J*. Structural basis for the unique biological function of small GTPase human Rheb. J. Biol. Chem., 280, 17093-17100 (2005).
11. Li, J., Xia, Z., and Ding, J*. Thioredocin-like domain of human kappa class transferase reveals sequence homology and structure similarity to the theta class enzyme. Protein Science, 14, 2361-2369 (2005).
12. Cheng, A., Zhang, W., Xie, Y., Jiang, W., Arnold, E., Sarafianos, S.G., and Ding, J*. Expression, purification, and characterization of SARS coronavirus RNA polymerase. Virology, 335, 165-176 (2005).
13. Lin, X., Ma, Z.M., Yao, X., He, L.F., Yuan, Z.H., Ding, J.P., and Wen, Y.M. Substitution of proline 306 in the reverse transcriptase domain of hepatitis B virus regulates replication. J. Gen. Virol., 86, 85-90 (2005).
14. Tuske, S., Sarafianos, S.G., Clark, Jr., A.D., Ding, J., Naeger, L.K., White, K.L., Miller, M.D., Gibbs, C.S., Boyer, P.L., Clark, P., Wang, G., Gaffney, B.L., Jones, R.A., Jerina, D.M., Hughes, S.H., and Arnold, E. Structures of HIV-1 RT/DNA complexes before and after incorporation of tenofovir, a nucleotide anti-AIDS drug. Nature Struct. Mol. Biol., 11, 469-474 (2004).
15. Yu, Y., Liu, Y., Shen, N., Xu, Z., Xu, F., Jia, J., Jin, Y., Arnold, E., and Ding, J*. Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment at 2.5 resolution: insights into substrate recognition, tRNA binding, and angiogenesis activity. J. Biol. Chem., 279, 8378-8388 (2004).
16. Xu, X., Zhao, J., Xu, Z., Peng, B., Huang, Q., Arnold, E., and Ding, J*. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. J. Biol. Chem., 279, 33946-33957 (2004).
17. Xu, P., Liu, Y., Shan, S., Kong, Y., Zhou, Q., Li, M., Ding, J.*, Xie, Y.*, and Wang, Y*. Molecular mechanism for the potentiation of the transcriptional activity of human liver receptor homologue 1 by steroid receptor coactivator-1. Mol. Endocrinol., 18, 1887-1905 (2004).
18. Yu, Y., Chang, Y., Li, S., Hu, H., Huang, Q., and Ding, J*. Expression, purification, crystallization and preliminary structural characterization of the GTPase domain of human Rheb. Acta Crystallogr. D60, 1883-1887 (2004).
19. Ge, Y.Z, Pu, M.T., Gowher, H., Wu, H.P., Ding, J.P., Jeltsch, A., and Xu, G.L. Chromatin targeting of de novo DNA methyltransferases by the PWWP domain. J. Biol. Chem., 279, 25447-25454 (2004).
20. Jia, J., Chen, X.L., Guo, L.T., Yu, Y.D., Ding, J.P., and Jin, Y.X. Residues K149 and E153 switch the aminoacylation of tRNATrp in Bacillus subtilis. J. Biol. Chem., 279, 41960-41965 (2004).
21. Gan, X., Ma, Z., Deng, N., Ding, J., and Li, L. Involvement of the C-terminal proline-rich motif of G protein-coupled receptor kinases in recognition of activated rhodopsin. J. Biol. Chem., 279, 49741-49746 (2004).
22. Yu, K., Fu, W., Liu, H., Luo, X., Chen, K.-X., Ding, J., Shen, J., and Jiang, H. Computational simulations of interactions of scorpion toxins with the voltage-gated potassium ion channel. Biophys. J., 86, 3542-3555 (2004).
23. Xu, X., Liu, Y., Weiss, S., Arnold, E., Sarafianos, S.G., and Ding, J*. Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design. Nucleic Acids Research, 31, 7117-7130 (2003).
24. Xu, Z., Liu, Y., Yang, Y., Jiang, W., Arnold, E., and Ding, J*. Crystal structure of D-hydantoinase from Burkholderia pickettii at 2.7 resolution: insights into the molecular determinants of enzyme thermostability. J. Bacteriology, 185, 4038-4049 (2003).
25. Shen, L., Shen, J., Luo, X., Cheng, F., Xu, Y., Chen, K., Arnold, E., Ding, J.*, and Jiang, H*. Steered molecular dynamics simulation on the binding of NNRTI to HIV-1 RT. Biophys. J., 84, 3547-3563 (2003).
26. Ding, J., Smith, A.D., Geisler, S.C., Arnold, G.F., and Arnold, E. Crystal structure of human rhinovirus type 14:human immunodeficiency virus type 1 (HIV-1) V3 loop chimera that induces potent neutralizing antibody response against HIV-1. Structure, 10, 999-1011 (2002).
