周金秋
研究员 分子生物学国家重点实验室研究组组长 博士生导师
Email:zhoulab@sibs.ac.cn
个人简介
1984年至1988就读于南京大学生物系，获学士学位。1992至1997年就读于美国迈阿密大学医学院生物化学与分子生物学系，获博士学位。1998年至2001，在美国普林斯顿大学分子生物学系接受博士后训练。2001年9月，作为”百人计划”入选者受聘于生物化学与细胞生物学研究所，任研究员，博士生导师，2002年1月起，任中国科学院与德国马普学会合作的青年科学家小组组长。
研究工作
我们实验室的长远目标是探索真核细胞维持染色体稳定性的机制和细胞衰老的机理。目前主要研究：（1）染色体末端--端粒的结构、功能与复制，及其与癌症和细胞衰老的关系；（2）不依赖端粒长度的细胞衰老的机理。我们大部分的工作集中在端粒的结构、功能及复制，真核生物端粒酶活性是如何被调节的，端粒酶活性和端粒长短的调节对于癌症和细胞衰老的生物学意义等方面。
近期论文
Zhang Deng-Hong *, Zhou Bo *, Huang Yu, Xu Lu-Xia and Zhou Jin-Qiu (2006). The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. Nucleic Acids Research. Accepted. *Co-first author
Yang Cui-Ping, Chen Yong-Bin, Meng Fei-Long and Zhou Jin-Qiu (2006). Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo. Nucleic Acids Research. 34:407-416
Chen Y-B, Yang C-P, Li R-X, Zeng R, and Zhou J-Q (2005). Def1p is involved in telomere maintenance in budding yeast. J Biol Chem. 280:24784-24791
Liao X-H, Zhang M-L, Yang C-P, Xu L-X and Zhou J-Q (2005). Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast. Biochemical Journal 390:169-176
Zhou J.-Q.* , Qi H.*, Schulz V.P., Mateyak M.K., Monson E.K., Zakian V.A. (2002) Schizosaccharomyces pombe pfh1(+) Encodes an Essential 5` to 3` DNA Helicase That Is a Member of the PIF1 Subfamily of DNA Helicases. Mol Biol Cell. 13:2180-91. *Co-first author
Ivessa A.S.*, Zhou J.-Q.*, Schulz V.P., Monson E.K., Zakian V.A. (2002). Saccharomyces Rrm3p, a 5` to 3` DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes Dev. 16:1383-96. *Co-first author
Zhou, J. -Q.; Monson, E. K.; Teng, S. -C.; Schulz, V. P.; and Zakian V. A. (2000). Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast. Science. 289: 771-774
Ivessa, A. S.*; Zhou, J. -Q.*; and Zakian V. A. (2000). The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell. 100: 479-489. *Co-first author
Zhou, J.-Q., He, H., Tan, C.-K., Downey, K.M., and So, A.G. (1997). The small subunit is required for functional interaction of DNA polymerase ? with the proliferating cell nuclear antigen. Nucleic Acids Res. 27:1094-1099.
Zhou, J.-Q., Tan, C-K., So, A.G., and Downey, K.M. (1996). Purification and characterization of the human catalytic subunit of human DNA polymerase & expressed in baculovirus-infected insect cells. J, Biol. Chem. 271:29740-29745
