陈建柱
客座研究员, 中国科学院“海外百人计划”获得者
中国科学院生物物理研究所 感染与免疫中心 主任
陈建柱 男，1962年8月出生，博士。
于1990年获得Stanford大学博士学位，并于1990至1993年在Columbia University及Harvard Medical School从事博士后研究。
从1993年至今在Massachusetts Institute of Technology任职，现为生物学系癌症研究中心教授。
曾获Harcourt General Charitable Fund New Investigator Award 及 Latham Family Career Development Award等奖。近五年来在Immunity, JEM, PNAS等刊物上发表数十篇论文。
主要研究方向为: 1)抗原识别受体多样性的形成; 2)免疫记忆的细胞和分子机理; 3)免疫系统一些重要分子的功能性研究。
Email: jchen@mit.edu
Selected Publications:
1. Ge, Q., Filip, L., Bai, A., Nguyen, T., Eisen, H.N., Chen, J. (2004) Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc. Natl. Acad. Sci. USA. 101: 8676-8681.
2. Ryu, C.J., Haines, B.B., Lee, H.R., Kang, Y.H., Draganov, D.D. Whitehurst, C.E., Hong, H.J., Chen, J. (2004) The TCRß variable gene promoter is required for efficient Vß rearrangement but not allelic exclusion. Mol. Cell Biol. 24:7015-7023.
3. Ge, Q., Bai, A., Jones, B., Eisen, H.N., Chen, J. (2004) Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors. Proc. Natl. Acad. Sci. USA. 101: 304-3046.
4. Cho, B., Varada, R., Ge, Q., Eisen, H. E., Chen, J. (2000) Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory cells. J. Exp. Med. 192:549-556.
5. Whitehurst C., Chattopadhyay S., and Chen, J. (1999) Control of V(D)J recombinational accessibility of the Dß1 gene segment at the TCRß locus by a germline promoter. Immunity 10:313-322.
研究组成员：
教授： 陈建柱
博士研究生： 丁熙来
English Version
Dr. Chen obtained his Ph.D. degree from Stanford University in 1990. From 1991 to 1994, he was a postdoctoral fellow and then an instructor at Harvard Medical School. He was awarded with a postdoctoral fellowship from the Cancer Research Institute and a New Investigator Award from the Arthritis Foundation. Currently, he is a professor of Biology at the Massachusetts Institute of Technology and an adjunct professor at the Chinese Academy of Sciences. His overall research interest is to elucidate the cellular and molecular basis of immunological memory and development of CD8 T cell vaccines. Using mouse models of influenza virus infection and prostate cancer, his lab is studying i) molecular mechanisms that mediate CD8 T cell response and memory to virus and cancer, and ii) CD8 T cell vaccines for prevention and/or treatment of virus infections in the respiratory tract and cancer. His group is also actively involved in developing short interfering RNA (siRNA) for influenza prophylaxis and therapy. In addition, his group studies the control of V(D)J recombination and how defect in the control leads to development of T cell lymphomas.
